AromaDb: A Database of Plant's Aroma Molecules

Carvacrol Details

: IUPAC Name
:Chemical Class
:CAS Registry Number
499-75-2
:Description

:Fragrance Type
spicy

Physical and Chemical properties

PUBCHEM ID 10364
Molecular Weight (g/mol) 150.222
Molecular Formula C10H14O
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 1
IUPAC Name
Canonical SMILES Cc1ccc(C(C)C)cc1O
PUBCHEM IUPAC INCHIKEY RECUKUPTGUEGMW-UHFFFAOYSA-N
Solubility Level 3
Vapour Pressure -2.144

Absorption and Metabolism information

XLOGP3 AA NA
CACTVS TPSA 29.6
BBB Level 1
Absorption Level 0
EXT PPB#Prediction 1
AlogP98 3.268
EXT CYP2D6#Prediction 0

Toxicological Information

Mouse Female FDA Multi-Carcinogen
Mouse Male FDA Multi-Carcinogen
Rat Female FDA Non-Carcinogen
Rat Male FDA Non-Carcinogen
Ames Prediction Non-Mutagen
Developmental / Reproductive Toxicity Non-Toxic
Rat Oral LD50 0.220133
Ocular Irritancy Severe
Hepatotoxic#Prediction 1
Effected Human Genes NA

Ecological Information

Aerobic Biodegradability Prediction Non-Degradable

Hazard(s) Identification

Physical hazards not classified
Health hazards Severe
Environmental hazards not classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteractionInteraction Actions PubMed Id
1499-75-2ANKRD17Gallus galluscarvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
2499-75-2AP1S3Gallus galluscarvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
3499-75-2CASP3Homo sapienscarvacrol results in increased activity of CASP3 protein increases^activity 23146755
4499-75-2CD5Gallus galluscarvacrol results in increased expression of CD5 mRNA increases^expression 20008804
5499-75-2COQ5Gallus galluscarvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
6499-75-2CXCL1Mus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
7499-75-2CXCL1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
8499-75-2DUSP1Gallus galluscarvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
9499-75-2FOSGallus galluscarvacrol results in increased expression of FOS mRNA increases^expression 20008804
10499-75-2HIPK2Gallus galluscarvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
11499-75-2IL1BMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
12499-75-2IL1BMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
13499-75-2LRRC59Gallus galluscarvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
14499-75-2MPOMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
15499-75-2MPOMus musculuscarvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
16499-75-2MSRB1Gallus galluscarvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
17499-75-2NFKB1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
18499-75-2OAZ1Gallus galluscarvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
19499-75-2PPP1R3BGallus galluscarvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
20499-75-2PRSS3Gallus galluscarvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
21499-75-2PTGS2Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
22499-75-2RYR1Sus scrofacarvacrol results in increased activity of RYR1 protein increases^activity 17641978
23499-75-2SLC15A1Gallus galluscarvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
24499-75-2SLC34A2Gallus galluscarvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
25499-75-2STK25Gallus galluscarvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
26499-75-2TMEM14AGallus galluscarvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
27499-75-2TNFMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
28499-75-2TNFMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
29499-75-2TRPA1Anolis carolinensiscarvacrol results in increased activity of TRPA1 protein increases^activity 22791718
30499-75-2TRPA1carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
31499-75-2TRPLDrosophila melanogastercarvacrol results in decreased activity of TRPL protein decreases^activity 19135721
32499-75-2TRPM7Mammaliacarvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
33499-75-2TRPV3Homo sapienscarvacrol results in increased activity of TRPV3 protein increases^activity 16617338
34499-75-2TRPV3Mus musculus[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
35499-75-2TRPV3Rattus norvegicuscarvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
36499-75-2TRPV3Rattus norvegicus[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
37499-75-2TRPV3Rattus norvegicusRuthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
38499-75-2TYRRRhipicephalus micropluscarvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
39499-75-2VAPBGallus galluscarvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
40499-75-2ANKRD17Gallus galluscarvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
41499-75-2AP1S3Gallus galluscarvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
42499-75-2CASP3Homo sapienscarvacrol results in increased activity of CASP3 protein increases^activity 23146755
43499-75-2CD5Gallus galluscarvacrol results in increased expression of CD5 mRNA increases^expression 20008804
44499-75-2COQ5Gallus galluscarvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
45499-75-2CXCL1Mus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
46499-75-2CXCL1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
47499-75-2DUSP1Gallus galluscarvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
48499-75-2FOSGallus galluscarvacrol results in increased expression of FOS mRNA increases^expression 20008804
49499-75-2HIPK2Gallus galluscarvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
50499-75-2IL1BMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
51499-75-2IL1BMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
52499-75-2LRRC59Gallus galluscarvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
53499-75-2MPOMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
54499-75-2MPOMus musculuscarvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
55499-75-2MSRB1Gallus galluscarvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
56499-75-2NFKB1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
57499-75-2OAZ1Gallus galluscarvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
58499-75-2PPP1R3BGallus galluscarvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
59499-75-2PRSS3Gallus galluscarvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
60499-75-2PTGS2Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
61499-75-2RYR1Sus scrofacarvacrol results in increased activity of RYR1 protein increases^activity 17641978
62499-75-2SLC15A1Gallus galluscarvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
63499-75-2SLC34A2Gallus galluscarvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
64499-75-2STK25Gallus galluscarvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
65499-75-2TMEM14AGallus galluscarvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
66499-75-2TNFMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
67499-75-2TNFMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
68499-75-2TRPA1Anolis carolinensiscarvacrol results in increased activity of TRPA1 protein increases^activity 22791718
69499-75-2TRPA1carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
70499-75-2TRPLDrosophila melanogastercarvacrol results in decreased activity of TRPL protein decreases^activity 19135721
71499-75-2TRPM7Mammaliacarvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
72499-75-2TRPV3Homo sapienscarvacrol results in increased activity of TRPV3 protein increases^activity 16617338
73499-75-2TRPV3Mus musculus[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
74499-75-2TRPV3Rattus norvegicuscarvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
75499-75-2TRPV3Rattus norvegicus[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
76499-75-2TRPV3Rattus norvegicusRuthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
77499-75-2TYRRRhipicephalus micropluscarvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
78499-75-2VAPBGallus galluscarvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
79499-75-2ANKRD17Gallus galluscarvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
80499-75-2AP1S3Gallus galluscarvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
81499-75-2CASP3Homo sapienscarvacrol results in increased activity of CASP3 protein increases^activity 23146755
82499-75-2CD5Gallus galluscarvacrol results in increased expression of CD5 mRNA increases^expression 20008804
83499-75-2COQ5Gallus galluscarvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
84499-75-2CXCL1Mus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
85499-75-2CXCL1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
86499-75-2DUSP1Gallus galluscarvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
87499-75-2FOSGallus galluscarvacrol results in increased expression of FOS mRNA increases^expression 20008804
88499-75-2HIPK2Gallus galluscarvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
89499-75-2IL1BMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
90499-75-2IL1BMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
91499-75-2LRRC59Gallus galluscarvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
92499-75-2MPOMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
93499-75-2MPOMus musculuscarvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
94499-75-2MSRB1Gallus galluscarvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
95499-75-2NFKB1Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
96499-75-2OAZ1Gallus galluscarvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
97499-75-2PPP1R3BGallus galluscarvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
98499-75-2PRSS3Gallus galluscarvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
99499-75-2PTGS2Mus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
100499-75-2RYR1Sus scrofacarvacrol results in increased activity of RYR1 protein increases^activity 17641978
101499-75-2SLC15A1Gallus galluscarvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
102499-75-2SLC34A2Gallus galluscarvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
103499-75-2STK25Gallus galluscarvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
104499-75-2TMEM14AGallus galluscarvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
105499-75-2TNFMus musculus2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
106499-75-2TNFMus musculuscarvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
107499-75-2TRPA1Anolis carolinensiscarvacrol results in increased activity of TRPA1 protein increases^activity 22791718
108499-75-2TRPA1carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
109499-75-2TRPLDrosophila melanogastercarvacrol results in decreased activity of TRPL protein decreases^activity 19135721
110499-75-2TRPM7Mammaliacarvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
111499-75-2TRPV3Homo sapienscarvacrol results in increased activity of TRPV3 protein increases^activity 16617338
112499-75-2TRPV3Mus musculus[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
113499-75-2TRPV3Rattus norvegicuscarvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
114499-75-2TRPV3Rattus norvegicus[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
115499-75-2TRPV3Rattus norvegicusRuthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
116499-75-2TYRRRhipicephalus micropluscarvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
117499-75-2VAPBGallus galluscarvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
Serial No. Activity Name DetailsReferences (PubMed)Other details EPA (U.S) Clinical Trials (U.S. NIH)
1 499-75-2 Carvacrol
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