CSIR CIMAP AROMA | Compound Details

Isoniazid Details

: IUPAC Name

pyridine-4-carbohydrazide

:Chemical Class

:CAS Registry Number

54-85-3

:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID	3767
Molecular Weight (g/mol)	137.139
Molecular Formula	C6H7N3O
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
IUPAC Name	pyridine-4-carbohydrazide
Canonical SMILES	NNC(=O)c1ccncc1
PUBCHEM IUPAC INCHIKEY	QRXWMOHMRWLFEY-UHFFFAOYSA-N
Solubility Level	4
Vapour Pressure	-4.647

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA	68
BBB Level	3
Absorption Level	0
EXT PPB#Prediction	0
AlogP98	-0.811
EXT CYP2D6#Prediction	0

Toxicological Information

Mouse Female FDA	Multi-Carcinogen
Mouse Male FDA	Multi-Carcinogen
Rat Female FDA	Single-Carcinogen
Rat Male FDA	Non-Carcinogen
Ames Prediction	Mutagen
Developmental / Reproductive Toxicity	Toxic
Rat Oral LD50	0.503305 g/kg_body_weight
Ocular Irritancy	Mild
Hepatotoxic#Prediction	1
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction	Non-Degradable

Hazard(s) Identification

Physical hazards	not classified
Health hazards	None
Environmental hazards	not classified

About Table Headings

Compound Biological Activity

Serial No.	Cas No	Gene Symbol	Organism	Interaction	Interaction Actions	PubMed Id
1	54-85-3	CCNA2	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCNA2 protein	decreases^expression	11468187
2	54-85-3	CCNB1	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCNB1 protein	decreases^expression	11468187
3	54-85-3	CCND1	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCND1 protein	decreases^expression	11468187
4	54-85-3	CCND2	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCND2 protein	decreases^expression	11468187
5	54-85-3	CCND3	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CCND3 protein	decreases^expression	11468187
6	54-85-3	CCNE1	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of CCNE1 protein	increases^expression	11468187
7	54-85-3	CCNT1	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [CDK9 protein binds to CCNT1 protein]	affects^binding\|decreases^reaction	17631934
8	54-85-3	CDK2	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased activity of CDK2 protein	decreases^activity	17631934
9	54-85-3	CDK2	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDK2 protein	decreases^expression	11468187
10	54-85-3	CDKN1A	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [Cisplatin results in increased expression of and affects the localization of CDKN1A protein]	affects^localization\|decreases^reaction\|increases^expression	12807743
11	54-85-3	CDKN1A	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [Dactinomycin results in increased expression of and affects the localization of CDKN1A protein]	affects^localization\|decreases^reaction\|increases^expression	12807743
12	54-85-3	CDKN1A	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein	decreases^expression	12807743
13	54-85-3	CDKN1A	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of CDKN1A mRNA	increases^expression	11468187\|12807743\|12869419
14	54-85-3	CDKN1A	Homo sapiens	ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein]	decreases^expression\|decreases^reaction	12807743
15	54-85-3	GADD45A	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of GADD45A mRNA	increases^expression	11468187
16	54-85-3	TFRC	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of TFRC protein	increases^expression	12807743
17	54-85-3	TP53	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of and affects the localization of and results in increased activity of TP53 protein	affects^localization\|increases^activity\|increases^expression	12869419
18	54-85-3	TP53	Homo sapiens	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of and affects the localization of TP53 protein	affects^localization\|increases^expression	12807743
19	54-85-3	A2M	Rattus norvegicus	Isoniazid results in increased expression of A2M mRNA	increases^expression	12883083
20	54-85-3	ABCC1	Rattus norvegicus	Isoniazid results in increased expression of ABCC1 mRNA	increases^expression	11752103
21	54-85-3	ABCC6	Rattus norvegicus	Isoniazid results in decreased expression of ABCC6 mRNA	decreases^expression	16260000
22	54-85-3	AGPAT3	Rattus norvegicus	Isoniazid results in increased expression of AGPAT3 mRNA	increases^expression	28619387
23	54-85-3	AGPAT3	Rattus norvegicus	silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	28619387
24	54-85-3	AGPAT3	Rattus norvegicus	[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA	affects^cotreatment\|increases^expression	28619387
25	54-85-3	AKR1B10	Homo sapiens	Isoniazid results in increased expression of AKR1B10 mRNA	increases^expression	28444390
26	54-85-3	ALAS1	Mus musculus	Isoniazid results in increased expression of ALAS1 protein	increases^expression	27438535
27	54-85-3	ALB	Bos taurus	[Isoniazid analog binds to Cobalt] which binds to ALB protein	affects^binding	22354161
28	54-85-3	ALB	Homo sapiens	Isoniazid binds to ALB protein	affects^binding	25489718
29	54-85-3	APOA4	Mus musculus	APOA4 affects the susceptibility to Isoniazid	affects^response to substance	24848797
30	54-85-3	APOA5	Rattus norvegicus	Isoniazid results in decreased expression of APOA5 mRNA	decreases^expression	28619387
31	54-85-3	APOA5	Rattus norvegicus	silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]	affects^cotreatment\|decreases^expression\|decreases^reaction	28619387
32	54-85-3	APOA5	Rattus norvegicus	[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA	affects^cotreatment\|decreases^expression	28619387
33	54-85-3	ASL	Rattus norvegicus	[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein	affects^cotreatment\|increases^activity	28619387
34	54-85-3	ASL	Rattus norvegicus	Isoniazid results in increased activity of ASL protein	increases^activity	28619387
35	54-85-3	ASL	Rattus norvegicus	silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]	affects^cotreatment\|decreases^reaction\|increases^activity	28619387
36	54-85-3	ATP5B	Mus musculus	Isoniazid affects the expression of ATP5B mRNA	affects^expression	24848797
37	54-85-3	ATP5F1	Mus musculus	Isoniazid affects the expression of ATP5F1 mRNA	affects^expression	24848797
38	54-85-3	ATP5G1	Mus musculus	Isoniazid affects the expression of ATP5G1 mRNA	affects^expression	24848797
39	54-85-3	ATP5G3	Mus musculus	Isoniazid affects the expression of ATP5G3 mRNA	affects^expression	24848797
40	54-85-3	ATP5J	Mus musculus	Isoniazid affects the expression of ATP5J mRNA	affects^expression	24848797
41	54-85-3	BAX	Mus musculus	[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein	affects^cotreatment\|increases^expression	21419764
42	54-85-3	BAX	Mus musculus	Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]	affects^cotreatment\|decreases^reaction\|increases^expression	21419764
43	54-85-3	BCL2	Mus musculus	[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein	affects^cotreatment\|decreases^expression	21419764
44	54-85-3	BCL2	Mus musculus	Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]	affects^cotreatment\|decreases^expression\|decreases^reaction	21419764
45	54-85-3	C10ORF10	Homo sapiens	Isoniazid results in increased expression of C10ORF10 mRNA	increases^expression	17175557
46	54-85-3	CASP3	Mus musculus	HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]	affects^cotreatment\|decreases^reaction\|increases^activity	23764483
47	54-85-3	CASP3	Mus musculus	[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein	affects^cotreatment\|increases^activity	21419764\|23764483
48	54-85-3	CASP3	Mus musculus	Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]	affects^cotreatment\|decreases^reaction\|increases^activity	21419764
49	54-85-3	CASR	Rattus norvegicus	Isoniazid affects the expression of CASR mRNA	affects^expression	20623750
50	54-85-3	CCR2	Rattus norvegicus	Isoniazid results in decreased expression of CCR2 mRNA	decreases^expression	20623750
51	54-85-3	CEBPA	Mus musculus	Isoniazid results in decreased expression of CEBPA mRNA	decreases^expression	24128855
52	54-85-3	CEBPA	Mus musculus	Isoniazid results in decreased expression of CEBPA protein	decreases^expression	24128855
53	54-85-3	CEBPB	Mus musculus	Isoniazid results in decreased expression of CEBPB protein	decreases^expression	24128855
54	54-85-3	CEBPD	Mus musculus	Isoniazid results in decreased expression of CEBPD mRNA	decreases^expression	24128855
55	54-85-3	CEBPD	Mus musculus	Isoniazid results in decreased expression of CEBPD protein	decreases^expression	24128855
56	54-85-3	CHPT1	Mus musculus	CHPT1 affects the susceptibility to Isoniazid	affects^response to substance	24848797
57	54-85-3	COX11	Mus musculus	Isoniazid affects the expression of COX11 mRNA	affects^expression	24848797
58	54-85-3	COX17	Mus musculus	Isoniazid affects the expression of COX17 mRNA	affects^expression	24848797
59	54-85-3	COX3	Rattus norvegicus	Isoniazid results in increased expression of COX3 mRNA	increases^expression	12883083
60	54-85-3	COX5B	Mus musculus	Isoniazid affects the expression of COX5B mRNA	affects^expression	24848797
61	54-85-3	COX6A1	Mus musculus	Isoniazid affects the expression of COX6A1 mRNA	affects^expression	24848797
62	54-85-3	COX6B1	Mus musculus	Isoniazid affects the expression of COX6B1 mRNA	affects^expression	24848797
63	54-85-3	COX7A2	Mus musculus	Isoniazid affects the expression of COX7A2 mRNA	affects^expression	24848797
64	54-85-3	CPT1A	Mus musculus	Isoniazid affects the expression of CPT1A mRNA	affects^expression	24848797
65	54-85-3	CYB5A	Rattus norvegicus	Isoniazid results in decreased expression of CYB5A mRNA	decreases^expression	28619387
66	54-85-3	CYB5A	Rattus norvegicus	silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]	affects^cotreatment\|decreases^expression\|decreases^reaction	28619387
67	54-85-3	CYB5A	Rattus norvegicus	[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA	affects^cotreatment\|decreases^expression	28619387
68	54-85-3	CYP2C23	Rattus norvegicus	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2C23 mRNA	affects^cotreatment\|increases^expression	27919644
69	54-85-3	CYP2C23	Rattus norvegicus	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2C23 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	27919644
70	54-85-3	CYP2C8	Homo sapiens	Isoniazid results in decreased activity of CYP2C8 protein	decreases^activity	15304522
71	54-85-3	CYP2C8	Homo sapiens	torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]	decreases^activity\|decreases^reaction	15304522
72	54-85-3	CYP2E1	Homo sapiens	CYP2E1 gene polymorphism affects the susceptibility to Isoniazid	affects^response to substance	12668988
73	54-85-3	CYP2E1	Homo sapiens	CYP2E1 gene SNP affects the susceptibility to Isoniazid	affects^response to substance	20485159
74	54-85-3	CYP2E1	Homo sapiens	Isoniazid results in increased expression of CYP2E1 protein	increases^expression	8074729
75	54-85-3	CYP2E1	Mus musculus	Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]	decreases^reaction\|increases^expression	22342832
76	54-85-3	CYP2E1	Mus musculus	Isoniazid results in increased expression of CYP2E1 mRNA	increases^expression	22342832
77	54-85-3	CYP2E1	Rattus norvegicus	2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	decreases^reaction\|increases^expression	9065729
78	54-85-3	CYP2E1	Rattus norvegicus	diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	decreases^reaction\|increases^activity	26880746
79	54-85-3	CYP2E1	Rattus norvegicus	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein	affects^cotreatment\|increases^activity	27919644
80	54-85-3	CYP2E1	Rattus norvegicus	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA	affects^cotreatment\|increases^expression	27919644
81	54-85-3	CYP2E1	Rattus norvegicus	Isoniazid results in increased activity of CYP2E1 protein	increases^activity	12458634\|15132840\|15205388\|19683030\|23211455\|25683034\|26880746\|9051121\|9129171
82	54-85-3	CYP2E1	Rattus norvegicus	[Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene	increases^activity\|increases^metabolic processing	9051121
83	54-85-3	CYP2E1	Rattus norvegicus	Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein	increases^activity\|increases^expression	18754103
84	54-85-3	CYP2E1	Rattus norvegicus	Isoniazid results in increased expression of CYP2E1	increases^expression	20566340
85	54-85-3	CYP2E1	Rattus norvegicus	[Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen	increases^expression\|increases^metabolic processing	20566340
86	54-85-3	CYP2E1	Rattus norvegicus	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	affects^cotreatment\|decreases^reaction\|increases^activity	27919644
87	54-85-3	CYP2E1	Rattus norvegicus	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	27919644
88	54-85-3	CYP2E1	Rattus norvegicus	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	affects^cotreatment\|decreases^reaction\|increases^activity	27919644
89	54-85-3	CYP2E1	Rattus norvegicus	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	27919644
90	54-85-3	CYP2E1	Rattus norvegicus	Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	decreases^reaction\|increases^expression	15132840
91	54-85-3	CYP2E1	Rattus norvegicus	Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	decreases^reaction\|increases^activity	12458634
92	54-85-3	CYP2E1	Rattus norvegicus	Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	decreases^reaction\|increases^activity	19683030
93	54-85-3	CYP2E1		Isoniazid results in decreased activity of CYP2E1 protein	decreases^activity	7710944
94	54-85-3	CYP2E1		Isoniazid results in increased activity of CYP2E1	increases^activity	12803597
95	54-85-3	CYP3A2	Rattus norvegicus	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA	affects^cotreatment\|increases^expression	27919644
96	54-85-3	CYP3A2	Rattus norvegicus	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	27919644
97	54-85-3	CYP3A2	Rattus norvegicus	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	27919644
98	54-85-3	CYP3A23/3A1	Rattus norvegicus	diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP3A23/3A1 protein]	decreases^reaction\|increases^activity	26880746
99	54-85-3	CYP3A23/3A1	Rattus norvegicus	Isoniazid results in increased activity of CYP3A23/3A1 protein	increases^activity	26880746
100	54-85-3	CYP3A23/3A1	Rattus norvegicus	Isoniazid results in increased expression of CYP3A23/3A1 mRNA	increases^expression	12883083
101	54-85-3	CYP3A4	Homo sapiens	CYP3A4 protein results in increased susceptibility to Isoniazid	increases^response to substance	21540358
102	54-85-3	CYP3A4	Homo sapiens	Isoniazid results in decreased activity of CYP3A4 protein	decreases^activity	15005856\|15304522
103	54-85-3	CYP3A4	Rattus norvegicus	[SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid	affects^cotreatment\|affects^response to substance	19501153
104	54-85-3	DDIT3	Rattus norvegicus	Isoniazid results in increased expression of DDIT3 mRNA	increases^expression	12883083
105	54-85-3	FECH	Mus musculus	Isoniazid results in decreased expression of FECH protein	decreases^expression	27438535
106	54-85-3	GADD45A	Rattus norvegicus	Isoniazid results in decreased expression of GADD45A mRNA	decreases^expression	20623750
107	54-85-3	GAPDH	Rattus norvegicus	Isoniazid results in increased expression of GAPDH mRNA	increases^expression	12883083
108	54-85-3	GCLC	Mus musculus	Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]	decreases^reaction\|increases^expression	24128855
109	54-85-3	GCLC	Mus musculus	Isoniazid results in decreased expression of GCLC mRNA	decreases^expression	24128855
110	54-85-3	GPT	Rattus norvegicus	Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]	increases^activity\|increases^reaction	28619387
111	54-85-3	GPT	Rattus norvegicus	Isoniazid results in increased activity of GPT protein	increases^activity	28619387
112	54-85-3	GPT	Rattus norvegicus	silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]	decreases^reaction\|increases^activity\|increases^reaction	28619387
113	54-85-3	GSTA2	Rattus norvegicus	Isoniazid results in increased expression of GSTA2 mRNA	increases^expression	12883083
114	54-85-3	GSTP1	Rattus norvegicus	Isoniazid results in decreased expression of GSTP1 mRNA	decreases^expression	20623750
115	54-85-3	GSTT1	Homo sapiens	GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]	affects^cotreatment\|affects^response to substance	20485159
116	54-85-3	GSTT1	Homo sapiens	GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]	affects^cotreatment\|increases^response to substance	18397238
117	54-85-3	HAVCR1	Rattus norvegicus	Isoniazid affects the expression of HAVCR1 mRNA	affects^expression	20623750
118	54-85-3	HGF	Mus musculus	HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]	affects^cotreatment\|decreases^reaction\|increases^abundance	23764483
119	54-85-3	HMOX1	Mus musculus	Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	24128855
120	54-85-3	HMOX1	Mus musculus	Isoniazid results in decreased expression of HMOX1 mRNA	decreases^expression	24128855
121	54-85-3	HMOX2	Rattus norvegicus	Isoniazid results in increased expression of HMOX2 mRNA	increases^expression	12883083
122	54-85-3	HPRT1	Rattus norvegicus	Isoniazid results in increased expression of HPRT1 mRNA	increases^expression	12883083
123	54-85-3	IL6	Mus musculus	Isoniazid results in increased expression of IL6 protein	increases^expression	19575532
124	54-85-3	INHBE	Homo sapiens	Isoniazid results in increased expression of INHBE mRNA	increases^expression	17175557
125	54-85-3	LAMP1	Mus musculus	LAMP1 affects the susceptibility to Isoniazid	affects^response to substance	24848797
126	54-85-3	LCN2	Rattus norvegicus	Isoniazid results in increased expression of LCN2 mRNA	increases^expression	20623750
127	54-85-3	MAP2	Mus musculus	Isoniazid affects the expression of MAP2 mRNA	affects^expression	22131109
128	54-85-3	NAT2	Homo sapiens	NAT2 gene polymorphism affects the susceptibility to Isoniazid	affects^response to substance	11379777\|11915035\|15618686\|20485159
129	54-85-3	NAT2	Homo sapiens	NAT2 gene SNP affects the susceptibility to Isoniazid	affects^response to substance	25794903
130	54-85-3	NAT2	Rattus norvegicus	Isoniazid results in decreased expression of NAT2 mRNA	decreases^expression	28619387
131	54-85-3	NAT2	Rattus norvegicus	silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]	affects^cotreatment\|decreases^expression\|decreases^reaction	28619387
132	54-85-3	NAT2	Rattus norvegicus	[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA	affects^cotreatment\|decreases^expression	28619387
133	54-85-3	NAT2		NAT2 protein polymorphism affects the susceptibility to Isoniazid	affects^response to substance	15855489
134	54-85-3	NDUFA1	Mus musculus	Isoniazid affects the expression of NDUFA1 mRNA	affects^expression	24848797
135	54-85-3	NDUFA10	Mus musculus	Isoniazid affects the expression of NDUFA10 mRNA	affects^expression	24848797
136	54-85-3	NDUFA12	Mus musculus	Isoniazid affects the expression of NDUFA12 mRNA	affects^expression	24848797
137	54-85-3	NDUFA13	Mus musculus	Isoniazid affects the expression of NDUFA13 mRNA	affects^expression	24848797
138	54-85-3	NDUFA4	Mus musculus	Isoniazid affects the expression of NDUFA4 mRNA	affects^expression	24848797
139	54-85-3	NDUFA5	Mus musculus	Isoniazid affects the expression of NDUFA5 mRNA	affects^expression	24848797
140	54-85-3	NDUFA8	Mus musculus	Isoniazid affects the expression of NDUFA8 mRNA	affects^expression	24848797
141	54-85-3	NDUFA9	Mus musculus	Isoniazid affects the expression of NDUFA9 mRNA	affects^expression	24848797
142	54-85-3	NDUFAB1	Mus musculus	Isoniazid affects the expression of NDUFAB1 mRNA	affects^expression	24848797
143	54-85-3	NDUFB10	Mus musculus	Isoniazid affects the expression of NDUFB10 mRNA	affects^expression	24848797
144	54-85-3	NDUFB2	Mus musculus	Isoniazid affects the expression of NDUFB2 mRNA	affects^expression	24848797
145	54-85-3	NDUFB3	Mus musculus	Isoniazid affects the expression of NDUFB3 mRNA	affects^expression	24848797
146	54-85-3	NDUFB5	Mus musculus	Isoniazid affects the expression of NDUFB5 mRNA	affects^expression	24848797
147	54-85-3	NDUFB6	Mus musculus	Isoniazid affects the expression of NDUFB6 mRNA	affects^expression	24848797
148	54-85-3	NDUFB7	Mus musculus	Isoniazid affects the expression of NDUFB7 mRNA	affects^expression	24848797
149	54-85-3	NDUFS1	Mus musculus	Isoniazid affects the expression of NDUFS1 mRNA	affects^expression	24848797
150	54-85-3	NDUFS2	Mus musculus	Isoniazid affects the expression of NDUFS2 mRNA	affects^expression	24848797
151	54-85-3	NDUFS3	Mus musculus	Isoniazid affects the expression of NDUFS3 mRNA	affects^expression	24848797
152	54-85-3	NDUFS4	Mus musculus	Isoniazid affects the expression of NDUFS4 mRNA	affects^expression	24848797
153	54-85-3	NDUFS8	Mus musculus	Isoniazid affects the expression of NDUFS8 mRNA	affects^expression	24848797
154	54-85-3	NDUFV1	Mus musculus	Isoniazid affects the expression of NDUFV1 mRNA	affects^expression	24848797
155	54-85-3	NDUFV2	Mus musculus	Isoniazid affects the expression of NDUFV2 mRNA	affects^expression	24848797
156	54-85-3	NQO1	Homo sapiens	Isoniazid results in increased expression of NQO1 mRNA	increases^expression	28444390
157	54-85-3	NQO1	Mus musculus	Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]	decreases^reaction\|increases^expression	24128855
158	54-85-3	NQO1	Mus musculus	Isoniazid results in decreased expression of NQO1 mRNA	decreases^expression	24128855
159	54-85-3	NUPR1	Homo sapiens	Isoniazid results in increased expression of NUPR1 mRNA	increases^expression	17175557
160	54-85-3	OGDH	Mus musculus	Isoniazid affects the expression of OGDH mRNA	affects^expression	24848797
161	54-85-3	PARK7	Mus musculus	Isoniazid affects the expression of PARK7 mRNA	affects^expression	24848797
162	54-85-3	PLOD2	Homo sapiens	Isoniazid results in increased expression of PLOD2 mRNA	increases^expression	15997088
163	54-85-3	POR	Rattus norvegicus	Isoniazid results in decreased expression of POR mRNA	decreases^expression	28619387
164	54-85-3	POR	Rattus norvegicus	silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]	affects^cotreatment\|decreases^expression\|decreases^reaction	28619387
165	54-85-3	POR	Rattus norvegicus	[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA	affects^cotreatment\|decreases^expression	28619387
166	54-85-3	PPARG	Homo sapiens	Isoniazid results in decreased expression of PPARG mRNA	decreases^expression	24128855
167	54-85-3	PPARG	Mus musculus	Isoniazid results in decreased expression of PPARG protein	decreases^expression	24128855
168	54-85-3	PSEN1	Mus musculus	Isoniazid affects the expression of PSEN1 mRNA	affects^expression	24848797
169	54-85-3	SDHA	Mus musculus	Isoniazid affects the expression of SDHA mRNA	affects^expression	24848797
170	54-85-3	SDHB	Mus musculus	Isoniazid affects the expression of SDHB mRNA	affects^expression	24848797
171	54-85-3	SDHD	Mus musculus	Isoniazid affects the expression of SDHD mRNA	affects^expression	24848797
172	54-85-3	SLC11A1	Rattus norvegicus	Isoniazid affects the expression of SLC11A1 mRNA	affects^expression	20623750
173	54-85-3	SOD2	Mus musculus	Isoniazid affects the expression of SOD2 mRNA	affects^expression	24848797
174	54-85-3	SORD	Cavia porcellus	Isoniazid results in increased expression of SORD protein	increases^expression	7401618
175	54-85-3	SPP1	Rattus norvegicus	Isoniazid affects the expression of SPP1 mRNA	affects^expression	20623750
176	54-85-3	SRXN1	Homo sapiens	Isoniazid results in increased expression of SRXN1 mRNA	increases^expression	28444390
177	54-85-3	SURF1	Mus musculus	Isoniazid affects the expression of SURF1 mRNA	affects^expression	24848797
178	54-85-3	TF	Rattus norvegicus	Isoniazid results in increased expression of TF mRNA	increases^expression	12883083
179	54-85-3	TNF	Rattus norvegicus	[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein	affects^cotreatment\|increases^expression	28619387
180	54-85-3	TNF	Rattus norvegicus	Isoniazid results in increased expression of TNF protein	increases^expression	28619387
181	54-85-3	TNF	Rattus norvegicus	silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]	affects^cotreatment\|decreases^reaction\|increases^expression	28619387
182	54-85-3	TPO	Rattus norvegicus	Isoniazid results in decreased activity of TPO protein	decreases^activity	26884060
183	54-85-3	TRAK1	Mus musculus	Isoniazid affects the expression of TRAK1 mRNA	affects^expression	24848797
184	54-85-3	TXN2	Mus musculus	Isoniazid affects the expression of TXN2 mRNA	affects^expression	24848797
185	54-85-3	TXNRD1	Homo sapiens	Isoniazid results in increased expression of TXNRD1 mRNA	increases^expression	28444390
186	54-85-3	TXNRD2	Mus musculus	Isoniazid affects the expression of TXNRD2 mRNA	affects^expression	24848797
187	54-85-3	UQCRB	Mus musculus	Isoniazid affects the expression of UQCRB mRNA	affects^expression	24848797
188	54-85-3	UQCRC2	Mus musculus	Isoniazid affects the expression of UQCRC2 mRNA	affects^expression	24848797
189	54-85-3	CYP1A1	Oryctolagus cuniculus	[pyridoxal isonicotinoyl hydrazone co-treated with Daunorubicin] results in increased activity of CYP1A1 protein	affects^cotreatment\|increases^activity	15588138
190	54-85-3	CYP1A1	Oryctolagus cuniculus	[pyridoxal isonicotinoyl hydrazone co-treated with Doxorubicin] results in increased activity of CYP1A1 protein	affects^cotreatment\|increases^activity	15588138
191	54-85-3	CYP1A1	Oryctolagus cuniculus	pyridoxal isonicotinoyl hydrazone results in decreased activity of CYP1A1 protein	decreases^activity	15588138
192	54-85-3	CYP1A2	Oryctolagus cuniculus	[pyridoxal isonicotinoyl hydrazone co-treated with Daunorubicin] results in increased activity of CYP1A2 protein	affects^cotreatment\|increases^activity	15588138
193	54-85-3	CYP1A2	Oryctolagus cuniculus	[pyridoxal isonicotinoyl hydrazone co-treated with Doxorubicin] results in increased activity of CYP1A2 protein	affects^cotreatment\|increases^activity	15588138
194	54-85-3	CYP1A2	Oryctolagus cuniculus	pyridoxal isonicotinoyl hydrazone results in decreased activity of CYP1A2 protein	decreases^activity	15588138

Serial No.	Activity Name	Details	References (PubMed)	Other details EPA (U.S)	Clinical Trials (U.S. NIH)
1				54-85-3	Isoniazid

Plant Variety and Essential oils

Serial No.	Plant Name	Variety Name	Essential Oil	Compound Percentage
1	Mulethi	Mishri	Glucyrrhiza glabra mulethi essential oil

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