AromaDb: A Database of Plant's Aroma Molecules

Dibunol Details

: IUPAC Name
2,6-ditert-butyl-4-methylphenol
:Chemical Class
Alcohol
:CAS Registry Number
128-37-0
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID 31404
Molecular Weight (g/mol) 220.35
Molecular Formula C15H24O
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 2
IUPAC Name 2,6-ditert-butyl-4-methylphenol
Canonical SMILES Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1
PUBCHEM IUPAC INCHIKEY NLZUEZXRPGMBCV-UHFFFAOYSA-N
Solubility Level 2
Vapour Pressure -2.649

Absorption and Metabolism information

XLOGP3 AA 5.3
CACTVS TPSA 20.2
BBB Level 0
Absorption Level 0
EXT PPB#Prediction 1
AlogP98 4.874
EXT CYP2D6#Prediction 0

Toxicological Information

Mouse Female FDA Non-Carcinogen
Mouse Male FDA Multi-Carcinogen
Rat Female FDA Non-Carcinogen
Rat Male FDA Non-Carcinogen
Ames Prediction Non-Mutagen
Developmental / Reproductive Toxicity Toxic
Rat Oral LD50 0.778548 g/kg_body_weight
Ocular Irritancy Moderate
Hepatotoxic#Prediction 0
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction Non-Degradable

Hazard(s) Identification

Physical hazards not classified
Health hazards Mild
Environmental hazards not classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteractionInteraction Actions PubMed Id
1128-37-0NR3C12,2'-methylenebis(ethyl-6-tert-butylphenol) results in decreased expression of NR3C1 mRNA decreases^expression 24518828
2128-37-0AHRMus musculus2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of AHR protein affects^binding|decreases^activity 27633901
3128-37-0ARHomo sapiens2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of AR protein affects^binding|decreases^activity 27633901
4128-37-0ESR1Homo sapiens2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of ESR1 protein affects^binding|decreases^activity 27633901
5128-37-0NR3C1Homo sapiens2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of NR3C1 protein affects^binding|decreases^activity 27633901
6128-37-0PGRHomo sapiens2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of PGR protein affects^binding|decreases^activity 27633901
7128-37-0THRBHomo sapiens2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in increased activity of THRB protein affects^binding|increases^activity 27633901
8128-37-0ARHomo sapiens2,6-di-tert-butyl-4-hydroxymethylphenol inhibits the reaction [Metribolone results in increased activity of AR protein] decreases^reaction|increases^activity 18324785
9128-37-0CASP3Homo sapiens2-tert-butyl-4-methylphenol results in decreased activity of CASP3 protein decreases^activity 14981915
10128-37-0CAT2-tert-butyl-4-methylphenol inhibits the reaction [1-hydroxyethyl radical results in decreased activity of CAT protein] decreases^activity|decreases^reaction 10600175
11128-37-0SOD2Homo sapiens2-tert-butyl-4-methylphenol results in decreased expression of SOD2 mRNA decreases^expression 14981915
12128-37-0ARHomo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein affects^binding|decreases^activity 27633901
13128-37-0ESR1Homo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein affects^binding|decreases^activity 27633901
14128-37-0NR3C1Homo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein affects^binding|decreases^activity 27633901
15128-37-0PGRHomo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein affects^binding|decreases^activity 27633901
16128-37-0PPARGHomo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein affects^binding|decreases^activity 27633901
17128-37-0THRBHomo sapiens3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein affects^binding|decreases^activity 27633901
18128-37-0ACTG1Mus musculusBHTOH-QM binds to ACTG1 protein affects^binding 16533022
19128-37-0ACTN2Mus musculusBHTOH-QM binds to ACTN2 protein affects^binding 16533022
20128-37-0ANXA3Mus musculusBHTOH-QM binds to ANXA3 protein affects^binding 16533022
21128-37-0CBR2Mus musculusBHTOH-QM results in decreased activity of CBR2 protein decreases^activity 18597497
22128-37-0CCT8Mus musculusBHTOH-QM binds to CCT8 protein affects^binding 16533022
23128-37-0EEF1A1Mus musculusBHTOH-QM binds to EEF1A1 protein affects^binding 16533022
24128-37-0ENO1Mus musculusBHTOH-QM binds to ENO1 protein affects^binding 16533022
25128-37-0HDLBPMus musculusBHTOH-QM binds to HDLBP protein affects^binding 16533022
26128-37-0HNRNPA2B1Mus musculusBHTOH-QM binds to HNRNPA2B1 protein affects^binding 16533022
27128-37-0HSP90AA1Mus musculusBHTOH-QM binds to HSP90AA1 protein affects^binding 16533022
28128-37-0HSP90AB1Mus musculusBHTOH-QM binds to HSP90AB1 protein affects^binding 16533022
29128-37-0HSP90B1Mus musculusBHTOH-QM binds to HSP90B1 protein affects^binding 16533022
30128-37-0HSPA8Mus musculusBHTOH-QM binds to HSPA8 protein affects^binding 16533022
31128-37-0LGALS1Mus musculusBHTOH-QM binds to LGALS1 protein affects^binding 16533022
32128-37-0PDIA3Mus musculusBHTOH-QM binds to PDIA3 protein affects^binding 16533022
33128-37-0PHGDHMus musculusBHTOH-QM binds to PHGDH protein affects^binding 16533022
34128-37-0PRDX2Mus musculusBHTOH-QM binds to PRDX2 protein affects^binding 16533022
35128-37-0STIP1Mus musculusBHTOH-QM binds to STIP1 protein affects^binding 16533022
36128-37-0TPI1Mus musculusBHTOH-QM binds to TPI1 protein affects^binding 16533022
37128-37-0TPM3Mus musculusBHTOH-QM binds to TPM3 protein affects^binding 16533022
38128-37-0ABCA1Homo sapiens[Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein affects^cotreatment|increases^expression 17070507
39128-37-0ABCA1Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA] decreases^expression|decreases^reaction 17070507
40128-37-0ABCA1Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein] decreases^expression|decreases^reaction 17070507
41128-37-0ABCA1Homo sapiensButylated Hydroxytoluene results in increased expression of ABCA1 mRNA increases^expression 17070507
42128-37-0ACTA2Homo sapiensButylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] decreases^reaction|increases^expression 16757516
43128-37-0ACTG1Rattus norvegicusButylated Hydroxytoluene results in increased expression of ACTG1 mRNA increases^expression 12082028
44128-37-0AGTMus musculusButylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] decreases^reaction|increases^expression 17532611
45128-37-0AHR2ASalmo salarButylated Hydroxytoluene results in increased expression of AHR2A mRNA increases^expression 19007167
46128-37-0AKR7A3Rattus norvegicusButylated Hydroxytoluene results in increased activity of AKR7A3 protein increases^activity 9328168
47128-37-0AKR7A3Rattus norvegicusButylated Hydroxytoluene results in increased expression of AKR7A3 protein increases^expression 8198522
48128-37-0ALOX15Oryctolagus cuniculusButylated Hydroxytoluene analog results in increased activity of ALOX15 protein increases^activity 7811748
49128-37-0APOA1Homo sapiens[Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] affects^cotreatment|decreases^reaction|increases^oxidation 12576517
50128-37-0APOA2Homo sapiens[Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] affects^cotreatment|decreases^reaction|increases^oxidation 12576517
51128-37-0APOA4Rattus norvegicusButylated Hydroxytoluene results in increased expression of APOA4 mRNA increases^expression 12082028
52128-37-0ARHomo sapiensButylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] affects^binding|decreases^reaction|increases^activity 10696776
53128-37-0ARG1Mus musculusButylated Hydroxytoluene results in increased expression of ARG1 mRNA increases^expression 19925653
54128-37-0ATP2A1Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] affects^cotreatment|decreases^activity|decreases^reaction 12870653
55128-37-0ATP2A1Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] decreases^activity|decreases^reaction 12870653
56128-37-0ATP6V1AHomo sapiensButylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein] decreases^expression|decreases^reaction 12470298
57128-37-0ATP6V1AMus musculusButylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein] decreases^expression|decreases^reaction 12470298
58128-37-0CA2Homo sapiensButylated Hydroxytoluene results in decreased activity of CA2 protein decreases^activity 19231207
59128-37-0CAPN2Mus musculusButylated Hydroxytoluene affects the expression of CAPN2 protein affects^expression 7716780
60128-37-0CAPRIN1Mus musculusButylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA increases^expression 19925653
61128-37-0CASP3Homo sapiens[Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein affects^cotreatment|decreases^activity 14981915
62128-37-0CASP3Homo sapiensButylated Hydroxytoluene results in decreased activity of CASP3 protein decreases^activity 14981915
63128-37-0CASP3Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein affects^cotreatment|increases^cleavage 16272459
64128-37-0CASP3Mus musculuszAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein] affects^cotreatment|decreases^reaction|increases^cleavage 16272459
65128-37-0CASP3Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein] decreases^reaction|increases^activity|increases^cleavage 10783138
66128-37-0CASP3Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein] decreases^reaction|increases^activity 27588890
67128-37-0CATRattus norvegicusButylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] decreases^activity|decreases^reaction 9306888
68128-37-0CCDC116Mus musculusButylated Hydroxytoluene results in increased expression of CCDC116 mRNA increases^expression 19925653
69128-37-0CCL17Mus musculusButylated Hydroxytoluene results in increased expression of CCL17 mRNA increases^expression 19925653
70128-37-0CCL2Mus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein] decreases^reaction|increases^expression 16822543
71128-37-0CCL2Mus musculusButylated Hydroxytoluene results in increased expression of CCL2 protein increases^expression 16443645
72128-37-0CCL5Mus musculusButylated Hydroxytoluene results in decreased expression of CCL5 mRNA decreases^expression 19925653
73128-37-0CCNA2Mus musculusButylated Hydroxytoluene results in increased expression of CCNA2 mRNA increases^expression 12867420
74128-37-0CCNA2Mus musculus[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA increases^expression 12867420
75128-37-0CCNB1Mus musculusButylated Hydroxytoluene results in increased expression of CCNB1 mRNA increases^expression 12867420|19000923
76128-37-0CCNB1Mus musculus[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA increases^expression 12867420
77128-37-0CCND1Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein affects^cotreatment|increases^expression 16272459
78128-37-0CCNE1Mus musculusButylated Hydroxytoluene results in increased expression of CCNE1 mRNA increases^expression 12867420
79128-37-0CCNE1Mus musculus[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA increases^expression 12867420
80128-37-0CCNFMus musculusButylated Hydroxytoluene results in increased expression of CCNF mRNA increases^expression 12867420
81128-37-0CCNFMus musculus[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA increases^expression 12867420
82128-37-0CD19Mus musculusButylated Hydroxytoluene results in decreased expression of CD19 mRNA decreases^expression 19925653
83128-37-0CD37Mus musculusButylated Hydroxytoluene results in decreased expression of CD37 mRNA decreases^expression 19925653
84128-37-0CD3DMus musculusButylated Hydroxytoluene results in decreased expression of CD3D mRNA decreases^expression 19925653
85128-37-0CD44Mus musculus[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form affects^cotreatment|increases^expression 15390079
86128-37-0CD81Rattus norvegicusButylated Hydroxytoluene results in increased expression of CD81 mRNA increases^expression 12082028
87128-37-0CDH1Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein affects^cotreatment|decreases^expression 16272459
88128-37-0CDK2AP2Rattus norvegicusButylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA increases^expression 12082028
89128-37-0CFIMus musculusButylated Hydroxytoluene results in increased expression of CFI mRNA increases^expression 19925653
90128-37-0CHEK1Mus musculusButylated Hydroxytoluene results in increased expression of CHEK1 mRNA increases^expression 19000923
91128-37-0CLDN2Mus musculusButylated Hydroxytoluene results in increased expression of CLDN2 mRNA increases^expression 19925653
92128-37-0COL18A1Mus musculusButylated Hydroxytoluene results in increased expression of COL18A1 mRNA increases^expression 19925653
93128-37-0COX2Homo sapiensButylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein] decreases^expression|decreases^reaction 12470298
94128-37-0COX2Mus musculusButylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein] decreases^expression|decreases^reaction 12470298
95128-37-0COX6B2Mus musculusButylated Hydroxytoluene results in increased expression of COX6B2 mRNA increases^expression 19925653
96128-37-0CSF2Mus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] decreases^reaction|increases^expression 16822543
97128-37-0CTNNB1Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein affects^cotreatment|affects^localization 16272459
98128-37-0CTNNB1Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein affects^cotreatment|increases^expression 16272459
99128-37-0CYP1APhasianidaeButylated Hydroxytoluene results in decreased activity of CYP1A protein decreases^activity 12659720
100128-37-0CYP1ASalmo salarButylated Hydroxytoluene affects the expression of CYP1A mRNA affects^expression 19007167
101128-37-0CYP1A1Meleagris gallopavoButylated Hydroxytoluene results in decreased activity of CYP1A1 protein decreases^activity 18177683
102128-37-0CYP1A1Mus musculusButylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] affects^reaction|increases^expression 21094198
103128-37-0CYP1A1Mus musculusButylated Hydroxytoluene results in increased expression of CYP1A1 mRNA increases^expression 19925653
104128-37-0CYP1A2Meleagris gallopavoButylated Hydroxytoluene results in decreased activity of CYP1A2 protein decreases^activity 18177683
105128-37-0CYP2B1Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2B1 mRNA increases^expression 15110098
106128-37-0CYP2B1Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2B1 protein increases^expression 15110098
107128-37-0CYP2B2Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2B2 mRNA increases^expression 12082028|15110098|18539377
108128-37-0CYP2B2Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2B2 protein increases^expression 15110098
109128-37-0CYP2B4Oryctolagus cuniculusButylated Hydroxytoluene binds to CYP2B4 protein affects^binding 18311926
110128-37-0CYP2B4Oryctolagus cuniculusCYP2B4 protein binds to and results in increased metabolism of Butylated Hydroxytoluene affects^binding|increases^metabolic processing 18700729
111128-37-0CYP2B6Homo sapiensButylated Hydroxytoluene results in increased expression of CYP2B6 mRNA increases^expression 18570159
112128-37-0CYP2C39Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2C39 mRNA increases^expression 12082028
113128-37-0CYP2C6V1Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP2C6V1 mRNA increases^expression 18539377
114128-37-0CYP2J2Homo sapiensButylated Hydroxytoluene results in increased expression of CYP2J2 mRNA increases^expression 24021950
115128-37-0CYP3ASalmo salarButylated Hydroxytoluene affects the expression of CYP3A protein affects^expression 19007167
116128-37-0CYP3A4Homo sapiensButylated Hydroxytoluene results in increased expression of CYP3A4 mRNA increases^expression 18570159
117128-37-0CYP3A4Meleagris gallopavoButylated Hydroxytoluene affects the activity of CYP3A4 protein affects^activity 18177683
118128-37-0CYP3A9Rattus norvegicusButylated Hydroxytoluene results in increased expression of CYP3A9 mRNA increases^expression 18539377
119128-37-0DCXRattus norvegicusButylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] decreases^expression|decreases^reaction 17067360
120128-37-0DNAJC3Mus musculusButylated Hydroxytoluene results in increased expression of DNAJC3 mRNA increases^expression 19925653
121128-37-0DOCK2Mus musculusButylated Hydroxytoluene results in decreased expression of DOCK2 mRNA decreases^expression 19925653
122128-37-0ELNMus musculus[Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA affects^cotreatment|increases^expression 10761639
123128-37-0EPORMus musculusButylated Hydroxytoluene results in increased expression of EPOR mRNA increases^expression 19925653
124128-37-0EREGMus musculusButylated Hydroxytoluene results in increased expression of EREG mRNA increases^expression 19925653
125128-37-0EVPLMus musculusButylated Hydroxytoluene results in increased expression of EVPL mRNA increases^expression 19925653
126128-37-0F3Homo sapiensButylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] decreases^reaction|increases^activity 7600656
127128-37-0FOSL1Mus musculusButylated Hydroxytoluene results in increased expression of FOSL1 mRNA increases^expression 19000923|19925653
128128-37-0FOXF1Mus musculusButylated Hydroxytoluene results in decreased expression of FOXF1 mRNA decreases^expression 11238010
129128-37-0FOXM1Mus musculusButylated Hydroxytoluene results in increased expression of FOXM1 mRNA increases^expression 11238010|12867420
130128-37-0FOXM1Mus musculusButylated Hydroxytoluene results in increased expression of FOXM1 protein increases^expression 11238010
131128-37-0FOXM1Mus musculusFOXM1 protein affects the susceptibility to Butylated Hydroxytoluene affects^response to substance 18345025|19672312
132128-37-0GCLCMus musculusButylated Hydroxytoluene results in increased expression of GCLC protein increases^expression 21536018
133128-37-0GCLCSus scrofaButylated Hydroxytoluene results in increased expression of GCLC mRNA increases^expression 9535746
134128-37-0GFPT2Mus musculusButylated Hydroxytoluene results in increased expression of GFPT2 mRNA increases^expression 19925653
135128-37-0GGTA1Mus musculusButylated Hydroxytoluene results in increased expression of GGTA1 mRNA increases^expression 19925653
136128-37-0GNMTRattus norvegicusButylated Hydroxytoluene results in increased expression of GNMT mRNA increases^expression 12082028
137128-37-0GPLD1Rattus norvegicusButylated Hydroxytoluene results in increased expression of GPLD1 mRNA increases^expression 12082028
138128-37-0GSTA3PhasianidaeButylated Hydroxytoluene results in increased expression of GSTA3 protein increases^expression 12659720
139128-37-0GSTA5PhasianidaeButylated Hydroxytoluene results in increased expression of GSTA5 protein increases^expression 12659720
140128-37-0GSTA5Rattus norvegicusButylated Hydroxytoluene results in increased activity of GSTA5 protein increases^activity 9328168
141128-37-0GSTA5Rattus norvegicusButylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein increases^activity|increases^expression 8198522
142128-37-0GSTM2Rattus norvegicusButylated Hydroxytoluene results in increased expression of GSTM2 mRNA increases^expression 12082028|18539377
143128-37-0GSTP1Mus musculusButylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein decreases^activity|increases^alkylation 21536018
144128-37-0GSTP1Rattus norvegicusButylated Hydroxytoluene results in increased expression of GSTP1 mRNA increases^expression 15110098
145128-37-0GSTS1Salmo salarButylated Hydroxytoluene affects the expression of GSTS1 mRNA affects^expression 19007167
146128-37-0GSTT1Rattus norvegicusButylated Hydroxytoluene results in increased expression of GSTT1 mRNA increases^expression 15110098
147128-37-0GZMAMus musculusButylated Hydroxytoluene results in decreased expression of GZMA mRNA decreases^expression 19925653
148128-37-0HCRattus norvegicusButylated Hydroxytoluene results in increased expression of HC mRNA increases^expression 12082028
149128-37-0HCKRattus norvegicusButylated Hydroxytoluene affects the expression of HCK mRNA affects^expression 18539377
150128-37-0HELLSMus musculusButylated Hydroxytoluene results in increased expression of HELLS mRNA increases^expression 19000923
151128-37-0HMGCRRattus norvegicusButylated Hydroxytoluene results in increased activity of HMGCR protein increases^activity 9199277
152128-37-0HMOX1Homo sapiensButylated Hydroxytoluene affects the expression of HMOX1 mRNA affects^expression 8743975
153128-37-0HMOX1Rattus norvegicusButylated Hydroxytoluene results in increased expression of HMOX1 mRNA increases^expression 12420312
154128-37-0HNF1AMus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA affects^cotreatment|increases^expression 16272459
155128-37-0HNRNPA1Mus musculus[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein affects^cotreatment|affects^localization 15390079
156128-37-0HNRNPA1Mus musculus[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein affects^cotreatment|increases^expression 15390079
157128-37-0HNRNPA1Mus musculusButylated Hydroxytoluene results in increased expression of HNRNPA1 protein increases^expression 15390079
158128-37-0HNRNPA2B1Mus musculus[Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein affects^cotreatment|affects^expression 17477362
159128-37-0HRASMus musculusHRAS protein results in increased susceptibility to Butylated Hydroxytoluene increases^response to substance 11599794
160128-37-0HSPA9Mus musculusButylated Hydroxytoluene results in increased expression of HSPA9 mRNA increases^expression 19925653
161128-37-0IL10Mus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] decreases^expression|decreases^reaction 16822543
162128-37-0IL15Rattus norvegicusButylated Hydroxytoluene affects the expression of IL15 mRNA affects^expression 18539377
163128-37-0IL1AMus musculusButylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] decreases^reaction|increases^expression 8435107
164128-37-0IL1RL1Mus musculusButylated Hydroxytoluene results in increased expression of IL1RL1 mRNA increases^expression 19000923
165128-37-0IL2Mus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] decreases^reaction|increases^expression 16822543
166128-37-0IL4Mus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] decreases^reaction|increases^expression 16822543
167128-37-0ILKMus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein affects^cotreatment|increases^expression 16272459
168128-37-0JUNBMus musculusButylated Hydroxytoluene results in increased expression of JUNB mRNA increases^expression 19000923
169128-37-0KNG1Mus musculusButylated Hydroxytoluene results in increased expression of KNG1 mRNA increases^expression 19925653
170128-37-0KRASMus musculusButylated Hydroxytoluene results in increased mutagenesis of KRAS gene increases^mutagenesis 20101149
171128-37-0LEF1Mus musculus[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA affects^cotreatment|increases^expression 16272459
172128-37-0LEPMus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] decreases^reaction|increases^expression 16822543
173128-37-0LPAHomo sapiensButylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] decreases^expression|decreases^reaction 10856522
174128-37-0LPAHomo sapiensButylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] decreases^reaction|increases^expression 10856522
175128-37-0LPAHomo sapiensButylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein] decreases^expression|decreases^reaction 10856522
176128-37-0LPAHomo sapiensButylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] decreases^reaction|increases^expression 10856522
177128-37-0MAPK1Oryctolagus cuniculusButylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of MAPK1 protein] decreases^reaction|increases^activity 17561096
178128-37-0MAPK14Mus musculusButylated Hydroxytoluene results in increased expression of MAPK14 mRNA increases^expression 19925653
179128-37-0MBPMus musculusButylated Hydroxytoluene results in increased expression of MBP mRNA increases^expression 19925653
180128-37-0MCM3Mus musculusButylated Hydroxytoluene results in increased expression of MCM3 mRNA increases^expression 19000923
181128-37-0MSH6Danio rerioButylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA] decreases^expression|decreases^reaction 23143036
182128-37-0MYL3Mus musculusButylated Hydroxytoluene results in increased expression of MYL3 mRNA increases^expression 19925653
183128-37-0NFE2L2Mus musculusNFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene decreases^response to substance 10535991
184128-37-0NFKB1Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases^reaction|increases^activity 15713255
185128-37-0NGFRattus norvegicusButylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] decreases^reaction|increases^expression 9748608
186128-37-0NQO1PhasianidaeButylated Hydroxytoluene results in increased activity of NQO1 protein increases^activity 12659720
187128-37-0NQO1Rattus norvegicusButylated Hydroxytoluene results in increased expression of NQO1 mRNA increases^expression 20308224
188128-37-0NR1H2Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] decreases^expression|decreases^reaction 17070507
189128-37-0NR1H3Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] decreases^expression|decreases^reaction 17070507
190128-37-0NR1I3Homo sapiensButylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form affects^binding|decreases^activity 20869355
191128-37-0NR1I3Homo sapiensButylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form affects^binding|increases^activity 20869355
192128-37-0NRASRattus norvegicusButylated Hydroxytoluene results in increased activity of NRAS increases^activity 3040652
193128-37-0NRBF2Rattus norvegicusButylated Hydroxytoluene results in increased expression of NRBF2 mRNA increases^expression 12082028
194128-37-0NUP54Mus musculusButylated Hydroxytoluene results in increased expression of NUP54 mRNA increases^expression 19000923
195128-37-0OGG1Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of OGG1 mRNA] decreases^expression|decreases^reaction 20676402
196128-37-0PARNMus musculusButylated Hydroxytoluene results in decreased expression of PARN mRNA decreases^expression 19925653
197128-37-0PARP1Homo sapiensButylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein] decreases^reaction|increases^activity 2126186
198128-37-0PARP1Homo sapiensButylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] decreases^reaction|increases^activity 2126186
199128-37-0PCNAMus musculusButylated Hydroxytoluene results in increased expression of PCNA protein increases^expression 11238010
200128-37-0PER2Mus musculusButylated Hydroxytoluene results in increased expression of PER2 mRNA increases^expression 19925653
201128-37-0PGK1Homo sapiensButylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] decreases^reaction|increases^expression 18603805
202128-37-0PHEXMus musculusButylated Hydroxytoluene results in increased expression of PHEX mRNA increases^expression 19000923
203128-37-0PIK3R5Mus musculusButylated Hydroxytoluene results in increased expression of PIK3R5 mRNA increases^expression 19000923
204128-37-0PKNOX2Mus musculusButylated Hydroxytoluene results in increased expression of PKNOX2 mRNA increases^expression 19925653
205128-37-0PLA2G4AMus musculusButylated Hydroxytoluene results in increased expression of PLA2G4A protein increases^expression 16443645
206128-37-0PNPLA8Oryctolagus cuniculusButylated Hydroxytoluene inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of PNPLA8 protein] decreases^activity|decreases^reaction 15153555
207128-37-0POMPRattus norvegicusButylated Hydroxytoluene results in increased expression of POMP mRNA increases^expression 12082028
208128-37-0PON1Homo sapiensButylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] affects^cotreatment|decreases^expression|decreases^reaction 16052486
209128-37-0PON2Homo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] decreases^reaction|increases^expression 17916643
210128-37-0POU2F1Mus musculusButylated Hydroxytoluene results in decreased expression of POU2F1 mRNA decreases^expression 19925653
211128-37-0PPARHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] decreases^expression|decreases^reaction 17070507
212128-37-0PPARGHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA] decreases^expression|decreases^reaction 17070507
213128-37-0PPARGMus musculusButylated Hydroxytoluene results in increased expression of PPARG mRNA increases^expression 19925653
214128-37-0PRKCAMus musculusButylated Hydroxytoluene results in decreased expression of PRKCA protein decreases^expression 7716780
215128-37-0PRL2C3Mus musculusButylated Hydroxytoluene results in increased expression of PRL2C3 mRNA increases^expression 19000923
216128-37-0PSMC6Homo sapiensButylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA] decreases^expression|decreases^reaction 12470298
217128-37-0PSMC6Mus musculusButylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA] decreases^expression|decreases^reaction 12470298
218128-37-0PTGS1Mus musculusButylated Hydroxytoluene results in increased expression of PTGS1 protein increases^expression 11696405
219128-37-0PTGS1Ovis ariesButylated Hydroxytoluene analog results in decreased activity of PTGS1 protein decreases^activity 16690318
220128-37-0PTGS2Mus musculusButylated Hydroxytoluene results in increased expression of PTGS2 protein increases^expression 11696405
221128-37-0PTGS2Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 17067360
222128-37-0PTHLHMus musculusButylated Hydroxytoluene results in increased expression of PTHLH mRNA increases^expression 19925653
223128-37-0RAB31Mus musculusButylated Hydroxytoluene results in decreased expression of RAB31 mRNA decreases^expression 19925653
224128-37-0RAD21Mus musculusButylated Hydroxytoluene results in increased expression of RAD21 mRNA increases^expression 19000923
225128-37-0RAD51AP1Mus musculusButylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA increases^expression 19000923
226128-37-0RELARattus norvegicusButylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein] decreases^activity|decreases^reaction 16478757
227128-37-0RELARattus norvegicusButylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein] decreases^activity|decreases^reaction 16478757
228128-37-0RELARattus norvegicusButylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases^reaction|increases^activity 15713255
229128-37-0RIF1Mus musculusButylated Hydroxytoluene results in increased expression of RIF1 mRNA increases^expression 19000923
230128-37-0RNF112Rattus norvegicusButylated Hydroxytoluene affects the expression of RNF112 mRNA affects^expression 18539377
231128-37-0SELLMus musculusButylated Hydroxytoluene results in decreased expression of SELL mRNA decreases^expression 19925653
232128-37-0SERPINH1Mus musculusButylated Hydroxytoluene results in increased expression of SERPINH1 mRNA increases^expression 19925653
233128-37-0SHISA2Mus musculusButylated Hydroxytoluene results in decreased expression of SHISA2 mRNA decreases^expression 19925653
234128-37-0SLC2A1Mus musculusButylated Hydroxytoluene results in increased expression of SLC2A1 mRNA increases^expression 19000923
235128-37-0SLC2A3Mus musculusButylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA decreases^expression 19925653
236128-37-0SLC39A11Mus musculusButylated Hydroxytoluene results in increased expression of SLC39A11 mRNA increases^expression 19925653
237128-37-0SLFN4Mus musculusButylated Hydroxytoluene results in decreased expression of SLFN4 mRNA decreases^expression 19925653
238128-37-0SMPD3Oryctolagus cuniculusButylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of SMPD3 protein] decreases^reaction|increases^activity 17561096
239128-37-0SOD2Homo sapiens[Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA affects^cotreatment|decreases^expression 14981915
240128-37-0SPIBMus musculusButylated Hydroxytoluene results in decreased expression of SPIB mRNA decreases^expression 19925653
241128-37-0SPP1Mus musculusButylated Hydroxytoluene results in increased expression of SPP1 mRNA increases^expression 19925653
242128-37-0SRSF1Mus musculus[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein affects^cotreatment|affects^localization 15390079
243128-37-0SRSF1Mus musculus[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein affects^cotreatment|increases^expression 15390079
244128-37-0SRSF1Mus musculusButylated Hydroxytoluene results in increased expression of SRSF1 protein increases^expression 15390079
245128-37-0STMN1Mus musculusButylated Hydroxytoluene results in increased expression of STMN1 mRNA increases^expression 19000923
246128-37-0STOMMus musculusButylated Hydroxytoluene results in increased expression of STOM mRNA increases^expression 19925653
247128-37-0TAC1Rattus norvegicusButylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] decreases^reaction|increases^expression 9748608
248128-37-0TDO2Mus musculusButylated Hydroxytoluene results in increased expression of TDO2 mRNA increases^expression 19925653
249128-37-0TDO2Rattus norvegicusButylated Hydroxytoluene affects the expression of TDO2 mRNA affects^expression 18539377
250128-37-0TFAMHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA] decreases^reaction|increases^expression 20676402
251128-37-0TFAMHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein] decreases^reaction|increases^expression 20676402
252128-37-0TFB1MHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M mRNA] decreases^reaction|increases^expression 20676402
253128-37-0TFB1MHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M protein] decreases^reaction|increases^expression 20676402
254128-37-0TFB2MHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA] decreases^reaction|increases^expression 20676402
255128-37-0TFB2MHomo sapiensButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein] decreases^reaction|increases^expression 20676402
256128-37-0TFRCMus musculusButylated Hydroxytoluene results in increased expression of TFRC mRNA increases^expression 19000923
257128-37-0TGFARattus norvegicusButylated Hydroxytoluene results in decreased susceptibility to TGFA protein decreases^response to substance 7593635
258128-37-0THPOMus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] decreases^reaction|increases^expression 16822543
259128-37-0TMEM45BMus musculusButylated Hydroxytoluene results in decreased expression of TMEM45B mRNA decreases^expression 19925653
260128-37-0TNCMus musculusButylated Hydroxytoluene results in increased expression of TNC mRNA increases^expression 19925653
261128-37-0TNFHomo sapiensButylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases^reaction|increases^expression 9721806
262128-37-0TNFHomo sapiensButylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 9721806
263128-37-0TNFHomo sapiensButylated Hydroxytoluene results in decreased expression of TNF protein decreases^expression 9721806
264128-37-0TNFHomo sapiensButylated Hydroxytoluene results in increased susceptibility to TNF protein increases^response to substance 16910777
265128-37-0TNFMus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein] decreases^reaction|increases^expression 16822543
266128-37-0TP53Rattus norvegicusButylated Hydroxytoluene results in increased expression of TP53 mRNA increases^expression 9780227
267128-37-0TTRRattus norvegicusButylated Hydroxytoluene results in increased expression of TTR mRNA increases^expression 12082028
268128-37-0UBE2G2Mus musculusButylated Hydroxytoluene results in increased expression of UBE2G2 mRNA increases^expression 19925653
269128-37-0UGTSalmo salarButylated Hydroxytoluene affects the expression of UGT mRNA affects^expression 19007167
270128-37-0VEGFAMus musculusButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein] decreases^reaction|increases^expression 16822543
271128-37-0VEGFAMus musculusButylated Hydroxytoluene results in increased expression of VEGFA mRNA increases^expression 19000923
272128-37-0PPARGHomo sapiensIrganox 1010 binds to and results in decreased activity of PPARG protein affects^binding|decreases^activity 27633901
273128-37-0PPARGHomo sapiensIrganox 1010 binds to and results in increased activity of PPARG protein affects^binding|increases^activity 27633901
274128-37-0THRBHomo sapiensIrganox 1010 binds to and results in decreased activity of THRB protein affects^binding|decreases^activity 27633901
275128-37-0CLURattus norvegicusLY 231617 affects the expression of CLU mRNA affects^expression 8915593
276128-37-0GFAPRattus norvegicusLY 231617 affects the expression of GFAP mRNA affects^expression 8915593
277128-37-0ESR1Homo sapiensSantowhite powder binds to ESR1 protein affects^binding 16231125
278128-37-0ESR1Homo sapiensSantowhite powder inhibits the reaction [Estradiol binds to ESR1 protein] affects^binding|decreases^reaction 16231125
Serial No. Activity Name DetailsReferences (PubMed)Other details EPA (U.S) Clinical Trials (U.S. NIH)
1 128-37-0 Dibunol
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