CSIR CIMAP AROMA | Compound Details

Trans-Permethrin Details

: IUPAC Name

(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate

:Chemical Class

:CAS Registry Number

52645-53-1

:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID	40326
Molecular Weight (g/mol)	391.288
Molecular Formula	C21H20Cl2O3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
IUPAC Name	(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
Canonical SMILES	CC1(C)C(/C=C(Cl)Cl)C1C(=O)OCc3cccc(Oc2ccccc2)c3
PUBCHEM IUPAC INCHIKEY	RLLPVAHGXHCWKJ-UHFFFAOYSA-N
Solubility Level	1
Vapour Pressure	-7.529

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA	35.5
BBB Level	0
Absorption Level	0
EXT PPB#Prediction	1
AlogP98	5.438
EXT CYP2D6#Prediction	1

Toxicological Information

Mouse Female FDA	Multi-Carcinogen
Mouse Male FDA	Single-Carcinogen
Rat Female FDA	Non-Carcinogen
Rat Male FDA	Non-Carcinogen
Ames Prediction	Mutagen
Developmental / Reproductive Toxicity	Toxic
Rat Oral LD50	0.70884 g/kg_body_weight
Ocular Irritancy	None
Hepatotoxic#Prediction	0
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction	Non-Degradable

Hazard(s) Identification

Physical hazards	not classified
Health hazards	Mild
Environmental hazards	not classified

About Table Headings

Compound Biological Activity

Serial No.	Cas No	Gene Symbol	Organism	Interaction	Interaction Actions	PubMed Id
1	52645-53-1	ABAT	Rattus norvegicus	Permethrin affects the activity of ABAT protein	affects^activity	15189238
2	52645-53-1	ABCA3	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of ABCA3 mRNA	affects^cotreatment\|increases^expression	22406618
3	52645-53-1	ABCA3	Aedes aegypti	Permethrin results in increased expression of ABCA3 mRNA	increases^expression	22406618
4	52645-53-1	ABCB4	Anopheles stephensi	Permethrin results in decreased expression of ABCB4 mRNA	decreases^expression	25073980
5	52645-53-1	ABCB6	Anopheles stephensi	Permethrin results in decreased expression of ABCB6 mRNA	decreases^expression	25073980
6	52645-53-1	ABCG2	Homo sapiens	Permethrin results in decreased activity of ABCG2 protein	decreases^activity	23169446
7	52645-53-1	ABCG4	Anopheles stephensi	Permethrin results in increased expression of ABCG4 mRNA	increases^expression	25073980
8	52645-53-1	ACE-1	Anopheles gambiae	ACE-1 protein mutant form inhibits the reaction [PARA-LIKE protein mutant form results in decreased susceptibility to Permethrin]	decreases^reaction\|decreases^response to substance	25471264
9	52645-53-1	ACE-1	Anopheles gambiae	ACE-1 protein mutant form results in decreased susceptibility to Permethrin	decreases^response to substance	25471264
10	52645-53-1	ACHE	Euphlyctis cyanophlyctis	Permethrin results in decreased activity of ACHE protein	decreases^activity	1459649
11	52645-53-1	ACHE	Rattus norvegicus	[DEET co-treated with Permethrin] results in decreased activity of ACHE protein	affects^cotreatment\|decreases^activity	11248143\|14713564
12	52645-53-1	ACHE	Rattus norvegicus	[DEET co-treated with Permethrin] results in increased activity of ACHE protein	affects^cotreatment\|increases^activity	14713564
13	52645-53-1	ACHE	Rattus norvegicus	[Malathion co-treated with Permethrin] results in decreased activity of ACHE protein	affects^cotreatment\|decreases^activity	14713564
14	52645-53-1	ACHE	Rattus norvegicus	[Malathion co-treated with Permethrin] results in increased activity of ACHE protein	affects^cotreatment\|increases^activity	14713564
15	52645-53-1	ACHE	Rattus norvegicus	Permethrin results in increased activity of ACHE protein	increases^activity	11248143\|14713564
16	52645-53-1	ACHE	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in decreased activity of ACHE protein	affects^cotreatment\|decreases^activity	11248143\|14751452
17	52645-53-1	ACHE	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of ACHE protein	affects^cotreatment\|increases^activity	14751452
18	52645-53-1	ACHE	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin] results in decreased activity of ACHE protein	affects^cotreatment\|decreases^activity	11248143
19	52645-53-1	ACHE	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin] results in increased activity of ACHE protein	affects^cotreatment\|increases^activity	14751452
20	52645-53-1	ADCY1	Rattus norvegicus	Permethrin results in decreased activity of ADCY1 protein	decreases^activity	2957417
21	52645-53-1	AHR	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of AHR mRNA	affects^cotreatment\|decreases^expression	22406618
22	52645-53-1	AHR	Aedes aegypti	Permethrin results in decreased expression of AHR mRNA	decreases^expression	22406618
23	52645-53-1	AIF1	Mus musculus	[Pyridostigmine Bromide co-treated with Permethrin] results in increased expression of AIF1 protein	affects^cotreatment\|increases^expression	27984134
24	52645-53-1	AK1	Homo sapiens	Permethrin results in increased activity of AK1 protein	increases^activity	19326768
25	52645-53-1	AKT1	Mus musculus	Permethrin inhibits the reaction [INS1 protein results in increased expression of and results in increased phosphorylation of AKT1 protein]	decreases^reaction\|increases^expression\|increases^phosphorylation	24911977
26	52645-53-1	AKT1	Mus musculus	Permethrin results in decreased expression of and results in increased phosphorylation of AKT1 protein	decreases^expression\|increases^phosphorylation	24911977
27	52645-53-1	ALB	Labeo rohita	Permethrin results in decreased expression of ALB protein	decreases^expression	14675832
28	52645-53-1	ALPHA-EST7	Drosophila melanogaster	ALPHA-EST7 protein results in increased hydrolysis of and results in decreased susceptibility to Permethrin	decreases^response to substance\|increases^hydrolysis	15857765
29	52645-53-1	ALPHA-EST9	Rhipicephalus microplus	ALPHA-EST9 protein results in decreased susceptibility to Permethrin	decreases^response to substance	12349861
30	52645-53-1	ALPHA-EST9	Rhipicephalus microplus	ALPHA-EST9 protein results in increased hydrolysis of and results in decreased susceptibility to Permethrin	decreases^response to substance\|increases^hydrolysis	12403427\|14570139
31	52645-53-1	ALPL	Homo sapiens	Permethrin inhibits the reaction [Progesterone results in increased activity of ALPL protein]	decreases^reaction\|increases^activity	16326432
32	52645-53-1	AR	Homo sapiens	[Dihydrotestosterone co-treated with Permethrin] results in decreased expression of AR mRNA	affects^cotreatment\|decreases^expression	16857237
33	52645-53-1	AR	Homo sapiens	Permethrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]	decreases^reaction\|increases^activity	17980950
34	52645-53-1	AR	Homo sapiens	Permethrin results in decreased activity of AR protein	decreases^activity	20410157
35	52645-53-1	AR	Homo sapiens	Permethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]	decreases^activity\|increases^activity	16621434
36	52645-53-1	ATP2B3	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of ATP2B3 mRNA	affects^cotreatment\|increases^expression	22406618
37	52645-53-1	ATP2B3	Aedes aegypti	Permethrin results in increased expression of ATP2B3 mRNA	increases^expression	22406618
38	52645-53-1	BAX	Rattus norvegicus	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of BAX protein	affects^cotreatment\|increases^expression	12587291
39	52645-53-1	BCHE	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin] results in increased activity of BCHE protein	affects^cotreatment\|increases^activity	14751452
40	52645-53-1	BDNF	Mus musculus	[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	15527870
41	52645-53-1	BDNF	Mus musculus	Permethrin inhibits the reaction [Potassium results in increased expression of BDNF mRNA]	decreases^reaction\|increases^expression	15527870
42	52645-53-1	BDNF	Mus musculus	Permethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]	decreases^reaction\|increases^expression	11082455
43	52645-53-1	BDNF	Mus musculus	Permethrin results in decreased expression of BDNF mRNA	decreases^expression	12111003
44	52645-53-1	BDNF	Rattus norvegicus	Permethrin results in increased expression of BDNF mRNA	increases^expression	19017407
45	52645-53-1	CABP5	Homo sapiens	CABP5 gene SNP affects the susceptibility to Permethrin	affects^response to substance	25622337
46	52645-53-1	CAMK1G	Rattus norvegicus	Permethrin results in increased expression of CAMK1G mRNA alternative form	increases^expression	20143453
47	52645-53-1	CAT	Rattus norvegicus	Permethrin results in increased activity of CAT protein	increases^activity	12965126\|28456543
48	52645-53-1	CAT	Rattus norvegicus	[Propoxur co-treated with Permethrin] results in increased activity of CAT protein	affects^cotreatment\|increases^activity	28456543
49	52645-53-1	CCL5	Rattus norvegicus	Permethrin results in increased expression of CCL5 protein	increases^expression	21616133
50	52645-53-1	CDC42	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of CDC42 mRNA	affects^cotreatment\|decreases^expression	22406618
51	52645-53-1	CDC42	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of CDC42 mRNA	affects^cotreatment\|increases^expression	22406618
52	52645-53-1	CDC42	Aedes aegypti	Permethrin results in decreased expression of CDC42 mRNA	decreases^expression	22406618
53	52645-53-1	CDC42	Aedes aegypti	Permethrin results in increased expression of CDC42 mRNA	increases^expression	22406618
54	52645-53-1	CEBPA	Mus musculus	Permethrin results in increased expression of CEBPA mRNA	increases^expression	24911977
55	52645-53-1	CHAT	Euphlyctis cyanophlyctis	Permethrin results in decreased activity of CHAT protein	decreases^activity	1459649
56	52645-53-1	CHAT	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein	affects^cotreatment\|increases^activity	11248143
57	52645-53-1	CHMP2A	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of CHMP2A mRNA	affects^cotreatment\|increases^expression	22406618
58	52645-53-1	CHMP2A	Aedes aegypti	Permethrin results in increased expression of CHMP2A mRNA	increases^expression	22406618
59	52645-53-1	CHRM1	Oncorhynchus gilae apache	Permethrin results in decreased expression of CHRM1	decreases^expression	9827057
60	52645-53-1	CHRM2	Rattus norvegicus	Permethrin promotes the reaction [AFDX 384 binds to CHRM2 protein]	affects^binding\|increases^reaction	11248143
61	52645-53-1	CHRM2	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]	affects^binding\|affects^cotreatment\|increases^reaction	14751452
62	52645-53-1	CHRM2	Rattus norvegicus	[Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]	affects^binding\|affects^cotreatment\|increases^reaction	14751452
63	52645-53-1	COPG2	Rattus norvegicus	Permethrin results in increased expression of COPG2 mRNA	increases^expression	19017407
64	52645-53-1	CPT1B	Mus musculus	Permethrin results in decreased expression of CPT1B mRNA	decreases^expression	24911977
65	52645-53-1	CRH	Rattus norvegicus	Permethrin results in increased expression of CRH mRNA	increases^expression	19017407
66	52645-53-1	CRZ	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of CRZ mRNA	affects^cotreatment\|decreases^expression	22406618
67	52645-53-1	CRZ	Aedes aegypti	Permethrin results in decreased expression of CRZ mRNA	decreases^expression	22406618
68	52645-53-1	CXCL12	Rattus norvegicus	Permethrin results in increased expression of CXCL12 mRNA	increases^expression	19017407
69	52645-53-1	CYB561	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of CYB561 mRNA	affects^cotreatment\|decreases^expression	22406618
70	52645-53-1	CYB561	Aedes aegypti	Permethrin results in decreased expression of CYB561 mRNA	decreases^expression	22406618
71	52645-53-1	CYB5A	Helicoverpa armigera	Permethrin results in increased expression of CYB5A mRNA	increases^expression	10620039
72	52645-53-1	CYC	Drosophila melanogaster	CYC protein results in decreased susceptibility to Permethrin	decreases^response to substance	20348229
73	52645-53-1	CYP11A1	Mus musculus	Permethrin analog results in decreased expression of CYP11A1 mRNA	decreases^expression	21745691
74	52645-53-1	CYP11A1	Mus musculus	Permethrin results in decreased expression of CYP11A1 mRNA	decreases^expression	17463061\|18455858
75	52645-53-1	CYP11A1	Mus musculus	Permethrin results in decreased expression of CYP11A1 protein	decreases^expression	17463061
76	52645-53-1	CYP19A1A	Danio rerio	Permethrin results in increased expression of CYP19A1A mRNA	increases^expression	19095286
77	52645-53-1	CYP19A1B	Danio rerio	Permethrin results in increased expression of CYP19A1B mRNA	increases^expression	19095286
78	52645-53-1	CYP1A1	Homo sapiens	Permethrin results in increased expression of CYP1A1 mRNA	increases^expression	19326768\|21784029
79	52645-53-1	CYP1A1	Homo sapiens	Permethrin results in increased expression of CYP1A1 protein	increases^expression	21784029
80	52645-53-1	CYP1A1	Rattus norvegicus	[Permethrin co-treated with Piperonyl Butoxide] results in increased expression of CYP1A1 mRNA	affects^cotreatment\|increases^expression	11377398
81	52645-53-1	CYP1A1	Rattus norvegicus	Permethrin results in decreased activity of CYP1A1 protein	decreases^activity	20009351
82	52645-53-1	CYP1A2	Homo sapiens	Permethrin results in increased expression of CYP1A2 mRNA	increases^expression	21784029
83	52645-53-1	CYP1A2	Homo sapiens	Permethrin results in increased expression of CYP1A2 protein	increases^expression	21784029
84	52645-53-1	CYP2A6	Homo sapiens	Permethrin results in increased expression of CYP2A6 mRNA	increases^expression	19326768
85	52645-53-1	CYP2B1	Rattus norvegicus	EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]	decreases^reaction\|increases^expression	11377398\|14722249
86	52645-53-1	CYP2B1	Rattus norvegicus	GH1 protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]	decreases^reaction\|increases^expression	14722249
87	52645-53-1	CYP2B1	Rattus norvegicus	[Permethrin co-treated with Piperonyl Butoxide] results in increased expression of CYP2B1 mRNA	affects^cotreatment\|increases^expression	11377398
88	52645-53-1	CYP2B1	Rattus norvegicus	Permethrin results in increased expression of CYP2B1 mRNA	increases^expression	11377398\|14722249
89	52645-53-1	CYP2B1	Rattus norvegicus	Piperonyl Butoxide inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]	decreases^reaction\|increases^expression	11377398
90	52645-53-1	CYP2B6	Homo sapiens	Permethrin affects the activity of CYP2B6 protein	affects^activity	21924250
91	52645-53-1	CYP2B6	Homo sapiens	Permethrin results in increased expression of CYP2B6 mRNA	increases^expression	19326768
92	52645-53-1	CYP314A1	Aedes aegypti	Permethrin results in increased expression of CYP314A1 mRNA	increases^expression	18405832
93	52645-53-1	CYP3A23/3A1	Rattus norvegicus	EGF protein inhibits the reaction [Permethrin results in increased expression of CYP3A23/3A1 mRNA]	decreases^reaction\|increases^expression	11377398
94	52645-53-1	CYP3A23/3A1	Rattus norvegicus	Permethrin results in increased expression of CYP3A23/3A1 mRNA	increases^expression	11377398
95	52645-53-1	CYP3A4	Homo sapiens	Permethrin results in decreased activity of CYP3A4 protein	decreases^activity	16790556\|21924250
96	52645-53-1	CYP3A4	Homo sapiens	Permethrin results in increased expression of CYP3A4 mRNA	increases^expression	19249324\|19326768
97	52645-53-1	CYP3A5	Homo sapiens	Permethrin results in increased expression of CYP3A5 mRNA	increases^expression	19326768
98	52645-53-1	CYP4G7	Tribolium castaneum	Permethrin results in increased expression of CYP4G7 mRNA	increases^expression	25607733
99	52645-53-1	DCTN6	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of DCTN6 mRNA	affects^cotreatment\|increases^expression	22406618
100	52645-53-1	DCTN6	Aedes aegypti	Permethrin results in decreased expression of DCTN6 mRNA	decreases^expression	22406618
101	52645-53-1	DCTN6	Aedes aegypti	Permethrin results in increased expression of DCTN6 mRNA	increases^expression	22406618
102	52645-53-1	DDC	Rattus norvegicus	Permethrin results in decreased expression of DDC mRNA	decreases^expression	19017407
103	52645-53-1	DUSP6	Rattus norvegicus	Permethrin results in increased expression of DUSP6 mRNA	increases^expression	19017407
104	52645-53-1	DYNC1I1	Rattus norvegicus	Permethrin results in increased expression of DYNC1I1 mRNA	increases^expression	19017407
105	52645-53-1	EGR1	Rattus norvegicus	Permethrin results in increased expression of EGR1 mRNA	increases^expression	19017407
106	52645-53-1	ERBB2	Homo sapiens	Permethrin results in increased activity of ERBB2 protein	increases^activity	11222871
107	52645-53-1	ERCC1	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of ERCC1 mRNA	affects^cotreatment\|increases^expression	22406618
108	52645-53-1	ERCC1	Aedes aegypti	Permethrin results in decreased expression of ERCC1 mRNA	decreases^expression	22406618
109	52645-53-1	ERCC1	Aedes aegypti	Permethrin results in increased expression of ERCC1 mRNA	increases^expression	22406618
110	52645-53-1	ESR1	Danio rerio	Permethrin results in increased expression of ESR1 mRNA	increases^expression	19095286
111	52645-53-1	ESR1	Homo sapiens	Permethrin metabolite binds to and results in increased activity of ESR1 protein	affects^binding\|increases^activity	16395479
112	52645-53-1	ESR1	Homo sapiens	Permethrin metabolite binds to ESR1 protein	affects^binding	20574910
113	52645-53-1	ESR1	Homo sapiens	Permethrin results in decreased expression of ESR1 mRNA	decreases^expression	20397420
114	52645-53-1	ESR1	Homo sapiens	Permethrin results in increased activity of ESR1 protein	increases^activity	15064155
115	52645-53-1	ESR1	Mus musculus	Permethrin metabolite results in increased expression of ESR1 mRNA	increases^expression	20574910
116	52645-53-1	ESR1	Rattus norvegicus	Permethrin binds to ESR1 protein	affects^binding	12396874
117	52645-53-1	ESR1	Rattus norvegicus	[Permethrin co-treated with Estradiol] results in decreased expression of ESR1	affects^cotreatment\|decreases^expression	25048945
118	52645-53-1	ESR1	Rattus norvegicus	Permethrin results in decreased activity of ESR1 protein	decreases^activity	20410157
119	52645-53-1	FABP4	Mus musculus	Permethrin results in increased expression of FABP4 mRNA	increases^expression	24911977
120	52645-53-1	FASN	Mus musculus	Permethrin results in increased expression of FASN mRNA	increases^expression	24911977
121	52645-53-1	FBXO22	Rattus norvegicus	Permethrin results in increased expression of FBXO22 mRNA	increases^expression	19017407
122	52645-53-1	FOS	Mus musculus	[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of FOS mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	15527870
123	52645-53-1	FOS	Mus musculus	Permethrin inhibits the reaction [Potassium results in increased expression of FOS mRNA]	decreases^reaction\|increases^expression	15527870
124	52645-53-1	FOS	Mus musculus	Permethrin inhibits the reaction [Veratridine results in increased expression of FOS mRNA]	decreases^reaction\|increases^expression	11082455
125	52645-53-1	FOS	Mus musculus	Permethrin results in decreased expression of FOS mRNA	decreases^expression	12111003
126	52645-53-1	FOS	Mus musculus	Permethrin results in decreased expression of FOS protein	decreases^expression	11082455
127	52645-53-1	FOS	Rattus norvegicus	Permethrin results in increased expression of FOS mRNA	increases^expression	19017407
128	52645-53-1	FOS	Rattus norvegicus	Permethrin results in increased expression of FOS protein	increases^expression	8856738
129	52645-53-1	GANAB	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of GANAB mRNA	affects^cotreatment\|decreases^expression	22406618
130	52645-53-1	GANAB	Aedes aegypti	Permethrin results in decreased expression of GANAB mRNA	decreases^expression	22406618
131	52645-53-1	GATA4	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of GATA4 mRNA	affects^cotreatment\|decreases^expression	22406618
132	52645-53-1	GATA4	Aedes aegypti	Permethrin results in increased expression of GATA4 mRNA	increases^expression	22406618
133	52645-53-1	GCAT	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of GCAT mRNA	affects^cotreatment\|decreases^expression	22406618
134	52645-53-1	GCAT	Aedes aegypti	Permethrin results in decreased expression of GCAT mRNA	decreases^expression	22406618
135	52645-53-1	GCAT	Aedes aegypti	Permethrin results in increased expression of GCAT mRNA	increases^expression	22406618
136	52645-53-1	GFAP	Mus musculus	Permethrin results in increased expression of GFAP protein	increases^expression	14555407
137	52645-53-1	GFAP	Mus musculus	[Pyridostigmine Bromide co-treated with Permethrin] results in increased expression of GFAP protein	affects^cotreatment\|increases^expression	27984134
138	52645-53-1	GFAP	Rattus norvegicus	[DEET co-treated with Permethrin] results in increased expression of GFAP protein	affects^cotreatment\|increases^expression	11681848
139	52645-53-1	GGT1	Rattus norvegicus	Permethrin results in increased activity of GGT1 protein	increases^activity	2902710
140	52645-53-1	GNA14	Rattus norvegicus	Permethrin results in increased expression of GNA14 mRNA	increases^expression	19017407
141	52645-53-1	GOT2	Rattus norvegicus	Permethrin results in decreased expression of GOT2 protein	decreases^expression	26631339
142	52645-53-1	GPD1	Rattus norvegicus	Permethrin results in increased expression of GPD1 mRNA	increases^expression	19017407
143	52645-53-1	GPX1	Rattus norvegicus	Permethrin results in decreased activity of GPX1 protein	decreases^activity	12965126
144	52645-53-1	GSR	Mus musculus	[Lindane co-treated with Permethrin] results in decreased activity of GSR protein	affects^cotreatment\|decreases^activity	16718366
145	52645-53-1	GSTD4	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of GSTD4 mRNA	affects^cotreatment\|increases^expression	22406618
146	52645-53-1	GSTD4	Aedes aegypti	Permethrin results in increased expression of GSTD4 mRNA	increases^expression	22406618
147	52645-53-1	GSTE2	Aedes aegypti	GSTE2 protein results in decreased susceptibility to Permethrin	decreases^response to substance	15944082\|24565444
148	52645-53-1	GSTE2	Anopheles funestus	GSTE2 protein affects the susceptibility to Permethrin	affects^response to substance	24565444
149	52645-53-1	GSTE4	Aedes aegypti	GSTE4 protein affects the susceptibility to Permethrin	affects^response to substance	24593293
150	52645-53-1	GSTE5	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of GSTE5 mRNA	affects^cotreatment\|increases^expression	22406618
151	52645-53-1	GSTE5	Aedes aegypti	Permethrin results in decreased expression of GSTE5 mRNA	decreases^expression	22406618
152	52645-53-1	GSTE5	Aedes aegypti	Permethrin results in increased expression of GSTE5 mRNA	increases^expression	22406618
153	52645-53-1	GSTE6	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of GSTE6 mRNA	affects^cotreatment\|increases^expression	22406618
154	52645-53-1	GSTE6	Aedes aegypti	Permethrin results in increased expression of GSTE6 mRNA	increases^expression	22406618
155	52645-53-1	HMGCR	Mus musculus	Permethrin analog results in decreased expression of HMGCR mRNA	decreases^expression	21745691
156	52645-53-1	HMGCS1	Mus musculus	Permethrin analog results in decreased expression of HMGCS1 mRNA	decreases^expression	21745691
157	52645-53-1	HR96	Drosophila melanogaster	HR96 protein results in decreased susceptibility to Permethrin	decreases^response to substance	20348229
158	52645-53-1	HR96	Drosophila melanogaster	[PDP1 protein results in increased expression of HR96 protein] which results in decreased susceptibility to Permethrin	decreases^response to substance\|increases^expression	20348229
159	52645-53-1	HSD17B13	Mus musculus	Permethrin analog results in decreased expression of HSD17B13 mRNA	decreases^expression	21745691
160	52645-53-1	HSD3B1	Mus musculus	Permethrin analog results in decreased expression of HSD3B1 mRNA	decreases^expression	21745691
161	52645-53-1	IFNG	Mus musculus	IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid]	affects^cotreatment\|affects^response to substance	14617103
162	52645-53-1	IFNG	Rattus norvegicus	Permethrin results in increased expression of IFNG protein	increases^expression	21616133
163	52645-53-1	IGFBP3	Rattus norvegicus	Permethrin results in increased expression of IGFBP3 mRNA	increases^expression	19017407
164	52645-53-1	IL1B	Rattus norvegicus	Permethrin results in increased expression of IL1B protein	increases^expression	21616133
165	52645-53-1	IL2	Rattus norvegicus	Permethrin results in increased expression of IL2 protein	increases^expression	21616133
166	52645-53-1	ITPA	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of ITPA mRNA	affects^cotreatment\|decreases^expression	22406618
167	52645-53-1	ITPA	Aedes aegypti	Permethrin results in decreased expression of ITPA mRNA	decreases^expression	22406618
168	52645-53-1	JUN	Rattus norvegicus	Permethrin results in increased expression of JUN protein	increases^expression	8856738
169	52645-53-1	KLF10	Homo sapiens	KLF10 gene SNP affects the susceptibility to Permethrin	affects^response to substance	25622337
170	52645-53-1	KMT2A	Homo sapiens	Permethrin results in increased mutagenesis of KMT2A gene	increases^mutagenesis	12937054
171	52645-53-1	LDH	Channa striata	Permethrin results in decreased activity of LDH protein	decreases^activity	10576906
172	52645-53-1	LPL	Mus musculus	Permethrin results in increased expression of LPL mRNA	increases^expression	24911977
173	52645-53-1	MAP2	Rattus norvegicus	[DEET co-treated with Permethrin] results in decreased expression of MAP2 protein	affects^cotreatment\|decreases^expression	11681848
174	52645-53-1	MAP2	Rattus norvegicus	Permethrin results in decreased expression of MAP2 protein	decreases^expression	11681848
175	52645-53-1	MAP2K2	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of MAP2K2 mRNA	affects^cotreatment\|decreases^expression	22406618
176	52645-53-1	MAP2K2	Aedes aegypti	Permethrin results in decreased expression of MAP2K2 mRNA	decreases^expression	22406618
177	52645-53-1	MBP	Rattus norvegicus	Permethrin results in decreased expression of MBP protein	decreases^expression	26631339
178	52645-53-1	MDH2	Rattus norvegicus	Permethrin results in decreased expression of MDH2 protein	decreases^expression	26631339
179	52645-53-1	MED10	Rattus norvegicus	Permethrin results in increased expression of MED10 mRNA	increases^expression	19017407
180	52645-53-1	MED30	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of MED30 mRNA	affects^cotreatment\|decreases^expression	22406618
181	52645-53-1	MED30	Aedes aegypti	Permethrin results in decreased expression of MED30 mRNA	decreases^expression	22406618
182	52645-53-1	MPI	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of MPI mRNA	affects^cotreatment\|increases^expression	22406618
183	52645-53-1	MPI	Aedes aegypti	Permethrin results in decreased expression of MPI mRNA	decreases^expression	22406618
184	52645-53-1	MPO	Rattus norvegicus	Permethrin results in increased activity of MPO protein	increases^activity	19772857
185	52645-53-1	MRPL17	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of MRPL17 mRNA	affects^cotreatment\|decreases^expression	22406618
186	52645-53-1	MRPL17	Aedes aegypti	Permethrin results in decreased expression of MRPL17 mRNA	decreases^expression	22406618
187	52645-53-1	MRPL17	Aedes aegypti	Permethrin results in increased expression of MRPL17 mRNA	increases^expression	22406618
188	52645-53-1	MRPL28	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of MRPL28 mRNA	affects^cotreatment\|increases^expression	22406618
189	52645-53-1	MRPL55	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of MRPL55 mRNA	affects^cotreatment\|increases^expression	22406618
190	52645-53-1	MRPL55	Aedes aegypti	Permethrin results in increased expression of MRPL55 mRNA	increases^expression	22406618
191	52645-53-1	MRPS18A	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of MRPS18A mRNA	affects^cotreatment\|increases^expression	22406618
192	52645-53-1	MRPS18A	Aedes aegypti	Permethrin results in increased expression of MRPS18A mRNA	increases^expression	22406618
193	52645-53-1	MRPS18B	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of MRPS18B mRNA	affects^cotreatment\|decreases^expression	22406618
194	52645-53-1	MRPS18B	Aedes aegypti	Permethrin results in decreased expression of MRPS18B mRNA	decreases^expression	22406618
195	52645-53-1	NACP60E	Drosophila melanogaster	NACP60E protein affects the reaction [PARA protein mutant form results in decreased susceptibility to Permethrin]	affects^reaction\|decreases^response to substance	25687544
196	52645-53-1	NCOA1	Homo sapiens	Permethrin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]	affects^binding\|increases^reaction	21924250
197	52645-53-1	NFE2L2	Rattus norvegicus	Permethrin results in increased expression of NFE2L2 mRNA	increases^expression	23566817\|23806482
198	52645-53-1	NOL10	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of NOL10 mRNA	affects^cotreatment\|increases^expression	22406618
199	52645-53-1	NOL10	Aedes aegypti	Permethrin results in decreased expression of NOL10 mRNA	decreases^expression	22406618
200	52645-53-1	NPC2	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of NPC2 mRNA	affects^cotreatment\|increases^expression	22406618
201	52645-53-1	NPC2	Aedes aegypti	Permethrin results in increased expression of NPC2 mRNA	increases^expression	22406618
202	52645-53-1	NR1I2	Homo sapiens	Permethrin binds to and results in increased activity of NR1I2 protein	affects^binding\|increases^activity	21115097
203	52645-53-1	NR1I2	Homo sapiens	Permethrin results in increased activity of NR1I2 protein	increases^activity	16565514\|19249324\|22206814
204	52645-53-1	NR1I3	Homo sapiens	Permethrin results in increased activity of NR1I3 protein	increases^activity	21924250\|26187274
205	52645-53-1	NR1I3	Mus musculus	Permethrin results in increased expression of NR1I3 mRNA	increases^expression	16929008
206	52645-53-1	NR4A2	Rattus norvegicus	Permethrin affects the expression of NR4A2 mRNA	affects^expression	23566817
207	52645-53-1	NR4A2	Rattus norvegicus	Permethrin results in decreased expression of NR4A2	decreases^expression	25048945
208	52645-53-1	NR4A2	Rattus norvegicus	Permethrin results in decreased expression of NR4A2 mRNA	decreases^expression	22056222\|23174539
209	52645-53-1	NR4A2	Rattus norvegicus	Permethrin results in decreased expression of NR4A2 protein	decreases^expression	22056222\|23174539
210	52645-53-1	NR4A2	Rattus norvegicus	Permethrin results in increased expression of NR4A2 protein	increases^expression	23566817
211	52645-53-1	NR4A3	Rattus norvegicus	Permethrin results in increased expression of NR4A3 mRNA	increases^expression	19017407
212	52645-53-1	NUDC	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of NUDC mRNA	affects^cotreatment\|increases^expression	22406618
213	52645-53-1	NUDC	Aedes aegypti	Permethrin results in increased expression of NUDC mRNA	increases^expression	22406618
214	52645-53-1	OFD1	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of OFD1 mRNA	affects^cotreatment\|decreases^expression	22406618
215	52645-53-1	OFD1	Aedes aegypti	Permethrin results in decreased expression of OFD1 mRNA	decreases^expression	22406618
216	52645-53-1	PAK1IP1	Rattus norvegicus	Permethrin results in increased expression of PAK1IP1 mRNA	increases^expression	19017407
217	52645-53-1	PARA	Aedes aegypti	PARA protein mutant form results in decreased susceptibility to Permethrin	decreases^response to substance	19829709
218	52645-53-1	PARA	Drosophila melanogaster	Permethrin results in decreased activity of [PARA protein binds to TIPE protein]	affects^binding\|decreases^activity	9236205
219	52645-53-1	PARA	Musca domestica	PARA protein results in increased susceptibility to Permethrin	increases^response to substance	18252244
220	52645-53-1	PARA-LIKE	Aedes aegypti	PARA-LIKE protein polymorphism affects the susceptibility to Permethrin	affects^response to substance	25166902
221	52645-53-1	PARA-LIKE	Anopheles gambiae	PARA-LIKE protein mutant form results in decreased susceptibility to Permethrin	decreases^response to substance	25471264
222	52645-53-1	PDP1	Drosophila melanogaster	PDP1 protein results in decreased susceptibility to Permethrin	decreases^response to substance	20348229
223	52645-53-1	PGR	Homo sapiens	Permethrin inhibits the reaction [Progesterone results in increased expression of PGR protein]	decreases^reaction\|increases^expression	16326432
224	52645-53-1	PNPLA2	Mus musculus	Permethrin results in increased expression of PNPLA2 mRNA	increases^expression	24911977
225	52645-53-1	POLR2H	Rattus norvegicus	Permethrin results in increased expression of POLR2H mRNA	increases^expression	19017407
226	52645-53-1	PPARG	Mus musculus	Permethrin results in increased expression of PPARG mRNA	increases^expression	24911977
227	52645-53-1	PPARG	Mus musculus	Permethrin results in increased expression of PPARG protein	increases^expression	24911977
228	52645-53-1	PREX1	Homo sapiens	PREX1 gene SNP affects the susceptibility to Permethrin	affects^response to substance	25622337
229	52645-53-1	PRIM2	Rattus norvegicus	Permethrin results in increased expression of PRIM2 mRNA	increases^expression	19017407
230	52645-53-1	PRPF8	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of PRPF8 mRNA	affects^cotreatment\|decreases^expression	22406618
231	52645-53-1	PRPF8	Aedes aegypti	Permethrin results in decreased expression of PRPF8 mRNA	decreases^expression	22406618
232	52645-53-1	PRPF8	Aedes aegypti	Permethrin results in increased expression of PRPF8 mRNA	increases^expression	22406618
233	52645-53-1	RAB32	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of RAB32 mRNA	affects^cotreatment\|increases^expression	22406618
234	52645-53-1	RAB32	Aedes aegypti	Permethrin results in decreased expression of RAB32 mRNA	decreases^expression	22406618
235	52645-53-1	RAB32	Aedes aegypti	Permethrin results in increased expression of RAB32 mRNA	increases^expression	22406618
236	52645-53-1	RAB6	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of RAB6 mRNA	affects^cotreatment\|decreases^expression	22406618
237	52645-53-1	RAB6	Aedes aegypti	Permethrin results in decreased expression of RAB6 mRNA	decreases^expression	22406618
238	52645-53-1	RASSF5	Rattus norvegicus	Permethrin results in increased expression of RASSF5 mRNA	increases^expression	19017407
239	52645-53-1	RELA	Rattus norvegicus	Permethrin affects the expression of RELA protein	affects^expression	23566817
240	52645-53-1	RELA	Rattus norvegicus	Permethrin results in increased expression of RELA mRNA	increases^expression	23566817
241	52645-53-1	RGD1307595	Rattus norvegicus	Permethrin results in increased expression of RGD1307595 mRNA	increases^expression	19017407
242	52645-53-1	RIMBP2	Rattus norvegicus	Permethrin results in increased expression of RIMBP2 mRNA	increases^expression	19017407
243	52645-53-1	RNF5	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of RNF5 mRNA	affects^cotreatment\|decreases^expression	22406618
244	52645-53-1	RNF5	Aedes aegypti	Permethrin results in decreased expression of RNF5 mRNA	decreases^expression	22406618
245	52645-53-1	RPL32	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of RPL32 mRNA	affects^cotreatment\|decreases^expression	22406618
246	52645-53-1	RPL32	Aedes aegypti	Permethrin results in decreased expression of RPL32 mRNA	decreases^expression	22406618
247	52645-53-1	RPLP2	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of RPLP2 mRNA	affects^cotreatment\|decreases^expression	22406618
248	52645-53-1	RPLP2	Aedes aegypti	Permethrin results in decreased expression of RPLP2 mRNA	decreases^expression	22406618
249	52645-53-1	RPS6	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of RPS6 mRNA	affects^cotreatment\|decreases^expression	22406618
250	52645-53-1	RPS6	Aedes aegypti	Permethrin results in decreased expression of RPS6 mRNA	decreases^expression	22406618
251	52645-53-1	S100G	Rattus norvegicus	[Permethrin co-treated with Estradiol] results in increased expression of S100G mRNA	affects^cotreatment\|increases^expression	15599112
252	52645-53-1	S100G	Rattus norvegicus	Permethrin results in increased expression of S100G mRNA	increases^expression	15599112
253	52645-53-1	SCN10A	Rattus norvegicus	Permethrin results in increased expression of SCN10A protein	increases^expression	24732443
254	52645-53-1	SCPEP1	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of SCPEP1 mRNA	affects^cotreatment\|increases^expression	22406618
255	52645-53-1	SCPEP1	Aedes aegypti	Permethrin results in increased expression of SCPEP1 mRNA	increases^expression	22406618
256	52645-53-1	SKP2	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of SKP2 mRNA	affects^cotreatment\|decreases^expression	22406618
257	52645-53-1	SKP2	Aedes aegypti	Permethrin results in decreased expression of SKP2 mRNA	decreases^expression	22406618
258	52645-53-1	SLC27A1	Rattus norvegicus	Permethrin results in decreased expression of SLC27A1 protein	decreases^expression	26631339
259	52645-53-1	SLC40A1	Rattus norvegicus	Permethrin results in decreased expression of SLC40A1 mRNA	decreases^expression	19017407
260	52645-53-1	SLC6A3	Homo sapiens	Permethrin affects the activity of SLC6A3 protein	affects^activity	16005927
261	52645-53-1	SLC6A3	Mus musculus	Permethrin results in decreased expression of SLC6A3 protein	decreases^expression	14555407
262	52645-53-1	SLC6A3	Mus musculus	Permethrin results in increased expression of SLC6A3 protein	increases^expression	12428726\|14575646\|16005927
263	52645-53-1	SNCA	Mus musculus	Permethrin results in increased expression of SNCA protein	increases^expression	14575646
264	52645-53-1	SOD1	Rattus norvegicus	Permethrin results in increased activity of SOD1 protein	increases^activity	12965126
265	52645-53-1	ST6GALNAC5	Rattus norvegicus	Permethrin results in increased expression of ST6GALNAC5 mRNA	increases^expression	19017407
266	52645-53-1	STAR	Mus musculus	Permethrin analog results in decreased expression of STAR mRNA	decreases^expression	21745691
267	52645-53-1	STAR	Mus musculus	Permethrin results in decreased expression of STAR mRNA	decreases^expression	17463061\|18455858
268	52645-53-1	STAR	Mus musculus	Permethrin results in decreased expression of STAR protein	decreases^expression	17463061
269	52645-53-1	SYP	Mus musculus	[Pyridostigmine Bromide co-treated with Permethrin] results in decreased expression of SYP protein	affects^cotreatment\|decreases^expression	25785457
270	52645-53-1	TAP1	Anopheles stephensi	Permethrin results in decreased expression of TAP1 mRNA	decreases^expression	25073980
271	52645-53-1	TCERG1	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of TCERG1 mRNA	affects^cotreatment\|increases^expression	22406618
272	52645-53-1	TCERG1	Aedes aegypti	Permethrin results in increased expression of TCERG1 mRNA	increases^expression	22406618
273	52645-53-1	TDO2	Mus musculus	Permethrin results in decreased activity of TDO2 protein	decreases^activity	2547861
274	52645-53-1	TF	Rattus norvegicus	Permethrin results in decreased expression of TF protein	decreases^expression	26631339
275	52645-53-1	TFF1	Homo sapiens	Permethrin results in increased expression of TFF1 mRNA	increases^expression	12396874\|20397420
276	52645-53-1	TH	Rattus norvegicus	Permethrin results in decreased expression of and results in decreased activity of TH protein	decreases^activity\|decreases^expression	15461254
277	52645-53-1	TH	Rattus norvegicus	Permethrin results in decreased expression of TH mRNA	decreases^expression	15461254
278	52645-53-1	THRB		Permethrin results in decreased activity of THRB protein	decreases^activity	20410157
279	52645-53-1	TMLHE	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in increased expression of TMLHE mRNA	affects^cotreatment\|increases^expression	22406618
280	52645-53-1	TMLHE	Aedes aegypti	Permethrin results in decreased expression of TMLHE mRNA	decreases^expression	22406618
281	52645-53-1	TMLHE	Aedes aegypti	Permethrin results in increased expression of TMLHE mRNA	increases^expression	22406618
282	52645-53-1	TNF	Mus musculus	TNF protein affects the susceptibility to Permethrin	affects^response to substance	14617103
283	52645-53-1	TP53	Rattus norvegicus	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TP53 protein	affects^cotreatment\|increases^expression	12587291
284	52645-53-1	TPI	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of TPI mRNA	affects^cotreatment\|decreases^expression	22406618
285	52645-53-1	TPI	Aedes aegypti	Permethrin results in decreased expression of TPI mRNA	decreases^expression	22406618
286	52645-53-1	TRAPPC6B	Aedes aegypti	[fluoranthene co-treated with Permethrin] results in decreased expression of TRAPPC6B mRNA	affects^cotreatment\|decreases^expression	22406618
287	52645-53-1	TRAPPC6B	Aedes aegypti	Permethrin results in decreased expression of TRAPPC6B mRNA	decreases^expression	22406618
288	52645-53-1	TSPO	Mus musculus	Permethrin analog results in decreased expression of TSPO mRNA	decreases^expression	21745691
289	52645-53-1	TSPO	Mus musculus	Permethrin results in decreased expression of TSPO mRNA	decreases^expression	17463061\|18455858
290	52645-53-1	TTR	Rattus norvegicus	Permethrin results in decreased expression of TTR protein	decreases^expression	26631339
291	52645-53-1	UAP1	Rattus norvegicus	Permethrin results in increased expression of UAP1 mRNA	increases^expression	19017407
292	52645-53-1	UBA52	Rattus norvegicus	Permethrin results in decreased expression of UBA52 protein	decreases^expression	26631339
293	52645-53-1	VTG	Oncorhynchus mykiss	Permethrin metabolite results in increased expression of VTG mRNA	increases^expression	20836506
294	52645-53-1	VTG	Oncorhynchus mykiss	Permethrin results in increased expression of VTG mRNA	increases^expression	20836506
295	52645-53-1	VTG	Oryzias latipes	Permethrin results in increased expression of VTG protein	increases^expression	20836506
296	52645-53-1	VTG1	Danio rerio	Permethrin results in increased expression of VTG1 mRNA	increases^expression	18499281\|19095286
297	52645-53-1	VTG2	Danio rerio	Permethrin results in increased expression of VTG2 mRNA	increases^expression	18499281
298	52645-53-1	WNT10B	Homo sapiens	Permethrin results in increased expression of WNT10B mRNA	increases^expression	12437293
299	52645-53-1	WRNIP1	Rattus norvegicus	Permethrin results in increased expression of WRNIP1 mRNA	increases^expression	19017407

Serial No.	Activity Name	Details	References (PubMed)	Other details EPA (U.S)	Clinical Trials (U.S. NIH)
1				52645-53-1	Trans-Permethrin

Plant Variety and Essential oils

Serial No.	Plant Name	Variety Name	Essential Oil	Compound Percentage
1	Mulethi	Mishri	Glucyrrhiza glabra mulethi essential oil

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