AromaDb: A Database of Plant's Aroma Molecules

Alpha-Linolnic Acid Details

: IUPAC Name
(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
:Chemical Class
Acid
:CAS Registry Number
463-40-1
:Description

:Fragrance Type
oily

Physical and Chemical properties

PUBCHEM ID 5280934
Molecular Weight (g/mol) 278.43
Molecular Formula C18H30O2
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 13
IUPAC Name (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
Canonical SMILES CC/C=C/C/C=C/C/C=C/CCCCCCCC(=O)O
PUBCHEM IUPAC INCHIKEY DTOSIQBPPRVQHS-PDBXOOCHSA-N
Solubility Level 2
Vapour Pressure -6.095

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA 37.3
BBB Level 0
Absorption Level 1
EXT PPB#Prediction 1
AlogP98 5.971
EXT CYP2D6#Prediction 0

Toxicological Information

Mouse Female FDA Non-Carcinogen
Mouse Male FDA Multi-Carcinogen
Rat Female FDA Single-Carcinogen
Rat Male FDA Non-Carcinogen
Ames Prediction Non-Mutagen
Developmental / Reproductive Toxicity Non-Toxic
Rat Oral LD50 4.83066 g/kg_body_weight
Ocular Irritancy None
Hepatotoxic#Prediction 0
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction Degradable

Hazard(s) Identification

Physical hazards not classified
Health hazards Moderate
Environmental hazards not classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteractionInteraction Actions PubMed Id
1463-40-1ABCB11Homo sapiensalpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] increases^expression|increases^reaction 15307955
2463-40-1ACACARattus norvegicusalpha-Linolenic Acid results in decreased expression of ACACA mRNA decreases^expression 14563831
3463-40-1ACLYRattus norvegicusalpha-Linolenic Acid results in decreased expression of ACLY mRNA decreases^expression 14563831
4463-40-1BCHEHomo sapiensalpha-Linolenic Acid results in increased expression of BCHE mRNA increases^expression 27106529
5463-40-1CATRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein] decreases^activity|decreases^reaction 22269903
6463-40-1CEBPBRattus norvegicusalpha-Linolenic Acid results in decreased expression of CEBPB mRNA decreases^expression 14563831
7463-40-1CPT1AHomo sapiensalpha-Linolenic Acid results in increased expression of CPT1A mRNA increases^expression 15307955
8463-40-1CYP1A2Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP1A2 protein decreases^activity 16978661
9463-40-1CYP24A1Homo sapiensalpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] decreases^reaction|increases^expression 19667161
10463-40-1CYP2C19Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C19 protein decreases^activity 16978661
11463-40-1CYP2C19Homo sapiensCYP2C19 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
12463-40-1CYP2C9Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C9 protein decreases^activity 16978661
13463-40-1CYP2C9Homo sapiensCYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
14463-40-1CYP2E1Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2E1 protein decreases^activity 16978661
15463-40-1CYP3A4Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP3A4 protein decreases^activity 16978661
16463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA affects^cotreatment|increases^expression 19576517
17463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|increases^expression 19576517
18463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA affects^cotreatment|decreases^expression 19576517
19463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|decreases^expression 19576517
20463-40-1FADS1Homo sapiensfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] affects^cotreatment|decreases^reaction|increases^expression 19576517
21463-40-1FASNRattus norvegicusalpha-Linolenic Acid results in decreased expression of FASN mRNA decreases^expression 14563831
22463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased activity of GCLC protein increases^activity 17092368
23463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased expression of GCLC mRNA increases^expression 17092368
24463-40-1GPTRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] decreases^reaction|increases^activity 22269903
25463-40-1HMOX1Homo sapiensalpha-Linolenic Acid results in increased expression of HMOX1 mRNA increases^expression 17092368
26463-40-1IL1BHomo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in increased expression of IL1B protein affects^cotreatment|increases^expression 16305726
27463-40-1IL4Homo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein affects^cotreatment|decreases^expression 16305726
28463-40-1KNG1Homo sapiensalpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] decreases^reaction|increases^expression 15307955
29463-40-1NR1H2Mus musculusalpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein affects^binding|increases^activity 16731579
30463-40-1NR1H4Homo sapiensalpha-Linolenic Acid binds to NR1H4 protein affects^binding 15307955
31463-40-1NR1H4Homo sapiensalpha-Linolenic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] decreases^reaction|increases^activity 15307955
32463-40-1PCK1Mus musculus[Glucose deficiency co-treated with alpha-Linolenic Acid] results in increased expression of PCK1 mRNA affects^cotreatment|increases^expression 8536680
33463-40-1PLIN2Mus musculusalpha-Linolenic Acid results in increased expression of PLIN2 mRNA increases^expression 16489205
34463-40-1PLIN2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PLIN2 protein increases^expression 16489205
35463-40-1PPARAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARA protein affects^binding|increases^activity 10403814|16731579
36463-40-1PPARAHomo sapiensalpha-Linolenic Acid results in increased expression of PPARA mRNA increases^expression 19667161
37463-40-1PPARAHomo sapiensCalcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA] increases^expression|increases^reaction 19667161
38463-40-1PPARBHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARB protein affects^binding|increases^activity 16731579
39463-40-1PPARDHomo sapiensalpha-Linolenic Acid results in increased expression of PPARD mRNA increases^expression 19667161
40463-40-1PPARDHomo sapiensCalcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA] increases^expression 19667161
41463-40-1PPARGHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARG protein affects^binding|increases^activity 16731579
42463-40-1PPARGHomo sapiensalpha-Linolenic Acid results in increased activity of PPARG protein increases^activity 20696231
43463-40-1PPARGMus musculusalpha-Linolenic Acid results in increased expression of PPARG mRNA increases^expression 18154422
44463-40-1PTGS2Homo sapiensalpha-Linolenic Acid results in increased expression of PTGS2 mRNA increases^expression 17092368
45463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in decreased expression of PTGS2 mRNA decreases^expression 14563831
46463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PTGS2 protein increases^expression 22476691
47463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases^reaction|increases^activity|increases^chemical synthesis 18155686
48463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 18155686
49463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 18155686
50463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of RXRA protein affects^binding|increases^activity 16731579
51463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to RXRA protein affects^binding 16258897
52463-40-1SREBF1Rattus norvegicusalpha-Linolenic Acid results in decreased expression of SREBF1 mRNA decreases^expression 14563831
53463-40-1TRPV1Rattus norvegicus[alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein affects^cotreatment|increases^activity 17038422
54463-40-1UCP2Rattus norvegicusalpha-Linolenic Acid results in increased expression of UCP2 mRNA increases^expression 11341955
55463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 mRNA] decreases^reaction|increases^expression 18155686
56463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 protein] decreases^reaction|increases^expression 18155686
57463-40-1VDRHomo sapiensalpha-Linolenic Acid results in increased expression of VDR mRNA increases^expression 19667161
58463-40-1VDRHomo sapiens[Calcitriol co-treated with alpha-Linolenic Acid] results in increased expression of VDR mRNA affects^cotreatment|increases^expression 19667161
59463-40-1LIPCMus musculus[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate affects^cotreatment|increases^abundance 24777581
60463-40-1APOA1Mus musculusperilla seed oil affects the expression of APOA1 protein affects^expression 10720173
61463-40-1APOA2Mus musculusperilla seed oil affects the expression of APOA2 protein affects^expression 10720173
62463-40-1ABCB11Homo sapiensalpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] increases^expression|increases^reaction 15307955
63463-40-1ACACARattus norvegicusalpha-Linolenic Acid results in decreased expression of ACACA mRNA decreases^expression 14563831
64463-40-1ACLYRattus norvegicusalpha-Linolenic Acid results in decreased expression of ACLY mRNA decreases^expression 14563831
65463-40-1BCHEHomo sapiensalpha-Linolenic Acid results in increased expression of BCHE mRNA increases^expression 27106529
66463-40-1CATRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein] decreases^activity|decreases^reaction 22269903
67463-40-1CEBPBRattus norvegicusalpha-Linolenic Acid results in decreased expression of CEBPB mRNA decreases^expression 14563831
68463-40-1CPT1AHomo sapiensalpha-Linolenic Acid results in increased expression of CPT1A mRNA increases^expression 15307955
69463-40-1CYP1A2Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP1A2 protein decreases^activity 16978661
70463-40-1CYP24A1Homo sapiensalpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] decreases^reaction|increases^expression 19667161
71463-40-1CYP2C19Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C19 protein decreases^activity 16978661
72463-40-1CYP2C19Homo sapiensCYP2C19 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
73463-40-1CYP2C9Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C9 protein decreases^activity 16978661
74463-40-1CYP2C9Homo sapiensCYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
75463-40-1CYP2E1Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2E1 protein decreases^activity 16978661
76463-40-1CYP3A4Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP3A4 protein decreases^activity 16978661
77463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA affects^cotreatment|increases^expression 19576517
78463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|increases^expression 19576517
79463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA affects^cotreatment|decreases^expression 19576517
80463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|decreases^expression 19576517
81463-40-1FADS1Homo sapiensfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] affects^cotreatment|decreases^reaction|increases^expression 19576517
82463-40-1FASNRattus norvegicusalpha-Linolenic Acid results in decreased expression of FASN mRNA decreases^expression 14563831
83463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased activity of GCLC protein increases^activity 17092368
84463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased expression of GCLC mRNA increases^expression 17092368
85463-40-1GPTRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] decreases^reaction|increases^activity 22269903
86463-40-1HMOX1Homo sapiensalpha-Linolenic Acid results in increased expression of HMOX1 mRNA increases^expression 17092368
87463-40-1IL1BHomo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in increased expression of IL1B protein affects^cotreatment|increases^expression 16305726
88463-40-1IL4Homo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein affects^cotreatment|decreases^expression 16305726
89463-40-1KNG1Homo sapiensalpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] decreases^reaction|increases^expression 15307955
90463-40-1NR1H2Mus musculusalpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein affects^binding|increases^activity 16731579
91463-40-1NR1H4Homo sapiensalpha-Linolenic Acid binds to NR1H4 protein affects^binding 15307955
92463-40-1NR1H4Homo sapiensalpha-Linolenic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] decreases^reaction|increases^activity 15307955
93463-40-1PCK1Mus musculus[Glucose deficiency co-treated with alpha-Linolenic Acid] results in increased expression of PCK1 mRNA affects^cotreatment|increases^expression 8536680
94463-40-1PLIN2Mus musculusalpha-Linolenic Acid results in increased expression of PLIN2 mRNA increases^expression 16489205
95463-40-1PLIN2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PLIN2 protein increases^expression 16489205
96463-40-1PPARAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARA protein affects^binding|increases^activity 10403814|16731579
97463-40-1PPARAHomo sapiensalpha-Linolenic Acid results in increased expression of PPARA mRNA increases^expression 19667161
98463-40-1PPARAHomo sapiensCalcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA] increases^expression|increases^reaction 19667161
99463-40-1PPARBHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARB protein affects^binding|increases^activity 16731579
100463-40-1PPARDHomo sapiensalpha-Linolenic Acid results in increased expression of PPARD mRNA increases^expression 19667161
101463-40-1PPARDHomo sapiensCalcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA] increases^expression 19667161
102463-40-1PPARGHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARG protein affects^binding|increases^activity 16731579
103463-40-1PPARGHomo sapiensalpha-Linolenic Acid results in increased activity of PPARG protein increases^activity 20696231
104463-40-1PPARGMus musculusalpha-Linolenic Acid results in increased expression of PPARG mRNA increases^expression 18154422
105463-40-1PTGS2Homo sapiensalpha-Linolenic Acid results in increased expression of PTGS2 mRNA increases^expression 17092368
106463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in decreased expression of PTGS2 mRNA decreases^expression 14563831
107463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PTGS2 protein increases^expression 22476691
108463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases^reaction|increases^activity|increases^chemical synthesis 18155686
109463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 18155686
110463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 18155686
111463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of RXRA protein affects^binding|increases^activity 16731579
112463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to RXRA protein affects^binding 16258897
113463-40-1SREBF1Rattus norvegicusalpha-Linolenic Acid results in decreased expression of SREBF1 mRNA decreases^expression 14563831
114463-40-1TRPV1Rattus norvegicus[alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein affects^cotreatment|increases^activity 17038422
115463-40-1UCP2Rattus norvegicusalpha-Linolenic Acid results in increased expression of UCP2 mRNA increases^expression 11341955
116463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 mRNA] decreases^reaction|increases^expression 18155686
117463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 protein] decreases^reaction|increases^expression 18155686
118463-40-1VDRHomo sapiensalpha-Linolenic Acid results in increased expression of VDR mRNA increases^expression 19667161
119463-40-1VDRHomo sapiens[Calcitriol co-treated with alpha-Linolenic Acid] results in increased expression of VDR mRNA affects^cotreatment|increases^expression 19667161
120463-40-1LIPCMus musculus[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate affects^cotreatment|increases^abundance 24777581
121463-40-1APOA1Mus musculusperilla seed oil affects the expression of APOA1 protein affects^expression 10720173
122463-40-1APOA2Mus musculusperilla seed oil affects the expression of APOA2 protein affects^expression 10720173
123463-40-1ABCB11Homo sapiensalpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] increases^expression|increases^reaction 15307955
124463-40-1ACACARattus norvegicusalpha-Linolenic Acid results in decreased expression of ACACA mRNA decreases^expression 14563831
125463-40-1ACLYRattus norvegicusalpha-Linolenic Acid results in decreased expression of ACLY mRNA decreases^expression 14563831
126463-40-1BCHEHomo sapiensalpha-Linolenic Acid results in increased expression of BCHE mRNA increases^expression 27106529
127463-40-1CATRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein] decreases^activity|decreases^reaction 22269903
128463-40-1CEBPBRattus norvegicusalpha-Linolenic Acid results in decreased expression of CEBPB mRNA decreases^expression 14563831
129463-40-1CPT1AHomo sapiensalpha-Linolenic Acid results in increased expression of CPT1A mRNA increases^expression 15307955
130463-40-1CYP1A2Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP1A2 protein decreases^activity 16978661
131463-40-1CYP24A1Homo sapiensalpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] decreases^reaction|increases^expression 19667161
132463-40-1CYP2C19Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C19 protein decreases^activity 16978661
133463-40-1CYP2C19Homo sapiensCYP2C19 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
134463-40-1CYP2C9Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2C9 protein decreases^activity 16978661
135463-40-1CYP2C9Homo sapiensCYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP] affects^cotreatment|increases^metabolic processing 16978661
136463-40-1CYP2E1Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP2E1 protein decreases^activity 16978661
137463-40-1CYP3A4Homo sapiensalpha-Linolenic Acid results in decreased activity of CYP3A4 protein decreases^activity 16978661
138463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA affects^cotreatment|increases^expression 19576517
139463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|increases^expression 19576517
140463-40-1FADS1Homo sapiens[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA affects^cotreatment|decreases^expression 19576517
141463-40-1FADS1Homo sapiens[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated affects^abundance|affects^cotreatment|decreases^expression 19576517
142463-40-1FADS1Homo sapiensfulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] affects^cotreatment|decreases^reaction|increases^expression 19576517
143463-40-1FASNRattus norvegicusalpha-Linolenic Acid results in decreased expression of FASN mRNA decreases^expression 14563831
144463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased activity of GCLC protein increases^activity 17092368
145463-40-1GCLCHomo sapiensalpha-Linolenic Acid results in increased expression of GCLC mRNA increases^expression 17092368
146463-40-1GPTRattus norvegicusalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] decreases^reaction|increases^activity 22269903
147463-40-1HMOX1Homo sapiensalpha-Linolenic Acid results in increased expression of HMOX1 mRNA increases^expression 17092368
148463-40-1IL1BHomo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in increased expression of IL1B protein affects^cotreatment|increases^expression 16305726
149463-40-1IL4Homo sapiens[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein affects^cotreatment|decreases^expression 16305726
150463-40-1KNG1Homo sapiensalpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] decreases^reaction|increases^expression 15307955
151463-40-1NR1H2Mus musculusalpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein affects^binding|increases^activity 16731579
152463-40-1NR1H4Homo sapiensalpha-Linolenic Acid binds to NR1H4 protein affects^binding 15307955
153463-40-1NR1H4Homo sapiensalpha-Linolenic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] decreases^reaction|increases^activity 15307955
154463-40-1PCK1Mus musculus[Glucose deficiency co-treated with alpha-Linolenic Acid] results in increased expression of PCK1 mRNA affects^cotreatment|increases^expression 8536680
155463-40-1PLIN2Mus musculusalpha-Linolenic Acid results in increased expression of PLIN2 mRNA increases^expression 16489205
156463-40-1PLIN2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PLIN2 protein increases^expression 16489205
157463-40-1PPARAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARA protein affects^binding|increases^activity 10403814|16731579
158463-40-1PPARAHomo sapiensalpha-Linolenic Acid results in increased expression of PPARA mRNA increases^expression 19667161
159463-40-1PPARAHomo sapiensCalcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA] increases^expression|increases^reaction 19667161
160463-40-1PPARBHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARB protein affects^binding|increases^activity 16731579
161463-40-1PPARDHomo sapiensalpha-Linolenic Acid results in increased expression of PPARD mRNA increases^expression 19667161
162463-40-1PPARDHomo sapiensCalcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA] increases^expression 19667161
163463-40-1PPARGHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of PPARG protein affects^binding|increases^activity 16731579
164463-40-1PPARGHomo sapiensalpha-Linolenic Acid results in increased activity of PPARG protein increases^activity 20696231
165463-40-1PPARGMus musculusalpha-Linolenic Acid results in increased expression of PPARG mRNA increases^expression 18154422
166463-40-1PTGS2Homo sapiensalpha-Linolenic Acid results in increased expression of PTGS2 mRNA increases^expression 17092368
167463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in decreased expression of PTGS2 mRNA decreases^expression 14563831
168463-40-1PTGS2Rattus norvegicusalpha-Linolenic Acid results in increased expression of PTGS2 protein increases^expression 22476691
169463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases^reaction|increases^activity|increases^chemical synthesis 18155686
170463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 18155686
171463-40-1PTGS2Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 18155686
172463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to and results in increased activity of RXRA protein affects^binding|increases^activity 16731579
173463-40-1RXRAHomo sapiensalpha-Linolenic Acid binds to RXRA protein affects^binding 16258897
174463-40-1SREBF1Rattus norvegicusalpha-Linolenic Acid results in decreased expression of SREBF1 mRNA decreases^expression 14563831
175463-40-1TRPV1Rattus norvegicus[alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein affects^cotreatment|increases^activity 17038422
176463-40-1UCP2Rattus norvegicusalpha-Linolenic Acid results in increased expression of UCP2 mRNA increases^expression 11341955
177463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 mRNA] decreases^reaction|increases^expression 18155686
178463-40-1VCAM1Sus scrofaalpha-Linolenic Acid inhibits the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 protein] decreases^reaction|increases^expression 18155686
179463-40-1VDRHomo sapiensalpha-Linolenic Acid results in increased expression of VDR mRNA increases^expression 19667161
180463-40-1VDRHomo sapiens[Calcitriol co-treated with alpha-Linolenic Acid] results in increased expression of VDR mRNA affects^cotreatment|increases^expression 19667161
181463-40-1LIPCMus musculus[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate affects^cotreatment|increases^abundance 24777581
182463-40-1APOA1Mus musculusperilla seed oil affects the expression of APOA1 protein affects^expression 10720173
183463-40-1APOA2Mus musculusperilla seed oil affects the expression of APOA2 protein affects^expression 10720173
Serial No. Activity Name DetailsReferences (PubMed)Other details EPA (U.S) Clinical Trials (U.S. NIH)
1 463-40-1 Alpha-Linolnic Acid

Plant Variety and Essential oils

Serial No. Plant NameVariety NameEssential OilCompound Percentage
1 Night-flowering Jasmine Nyctanthes essential oil
2 Night-flowering Jasmine Nyctanthes essential oil
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