4-Pyridinamine Details
:
IUPAC Name
pyridin-4-amine
:Chemical Class
:CAS Registry Number
504-24-5
:Description
:Fragrance Type
Physical and Chemical properties
| PUBCHEM ID | 1727 |
| Molecular Weight (g/mol) | 94.1145 |
| Molecular Formula | C5H6N2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| IUPAC Name | pyridin-4-amine |
| Canonical SMILES | Nc1ccncc1 |
| PUBCHEM IUPAC INCHIKEY | NUKYPUAOHBNCPY-UHFFFAOYSA-N |
| Solubility Level | 4 |
| Vapour Pressure | -1.277 |
Absorption and Metabolism information
| XLOGP3 AA | |
| CACTVS TPSA | 38.9 |
| BBB Level | 3 |
| Absorption Level | 0 |
| EXT PPB#Prediction | 0 |
| AlogP98 | -0.068 |
| EXT CYP2D6#Prediction | 0 |
Toxicological Information
| Mouse Female FDA | Single-Carcinogen |
| Mouse Male FDA | Single-Carcinogen |
| Rat Female FDA | Multi-Carcinogen |
| Rat Male FDA | Multi-Carcinogen |
| Ames Prediction | Mutagen |
| Developmental / Reproductive Toxicity | Non-Toxic |
| Rat Oral LD50 | 0.356592 g/kg_body_weight |
| Ocular Irritancy | Moderate |
| Hepatotoxic#Prediction | 1 |
| Effected Human Genes |
Ecological Information
| Aerobic Biodegradability Prediction | Non-Degradable |
Hazard(s) Identification
| Physical hazards | not classified |
| Health hazards | None |
| Environmental hazards | not classified |
Compound Biological Activity
| Serial No. | Cas No | Gene Symbol | Organism | Interaction | Interaction Actions | PubMed Id |
|---|---|---|---|---|---|---|
| 1 | 504-24-5 | ALK | Homo sapiens | 2,4-diaminopyridine analog binds to and results in decreased activity of ALK protein | affects^binding|decreases^activity | 22564207 |
| 2 | 504-24-5 | ADRA1B | Rattus norvegicus | 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] | decreases^reaction|increases^response to substance | 18480251 |
| 3 | 504-24-5 | BAX | Rattus norvegicus | 4-Aminopyridine results in increased expression of BAX mRNA | increases^expression | 24378259 |
| 4 | 504-24-5 | BIRC2 | Rattus norvegicus | 4-Aminopyridine results in decreased expression of BIRC2 mRNA | decreases^expression | 24378259 |
| 5 | 504-24-5 | BIRC3 | Rattus norvegicus | 4-Aminopyridine results in decreased expression of BIRC3 mRNA | decreases^expression | 24378259 |
| 6 | 504-24-5 | BMF | Rattus norvegicus | 4-Aminopyridine results in increased expression of BMF mRNA | increases^expression | 24378259 |
| 7 | 504-24-5 | C1ORF159 | Rattus norvegicus | 4-Aminopyridine results in increased expression of C1ORF159 mRNA | increases^expression | 24378259 |
| 8 | 504-24-5 | CASP3 | Rattus norvegicus | 4-Aminopyridine results in increased activity of CASP3 protein | increases^activity | 24378259 |
| 9 | 504-24-5 | CASP7 | Rattus norvegicus | 4-Aminopyridine results in increased activity of CASP7 protein | increases^activity | 24378259 |
| 10 | 504-24-5 | CASP9 | Rattus norvegicus | 4-Aminopyridine results in increased activity of CASP9 protein | increases^activity | 24378259 |
| 11 | 504-24-5 | CD40 | Rattus norvegicus | 4-Aminopyridine results in increased expression of CD40 mRNA | increases^expression | 24378259 |
| 12 | 504-24-5 | CD40LG | Rattus norvegicus | 4-Aminopyridine results in increased expression of CD40LG mRNA | increases^expression | 24378259 |
| 13 | 504-24-5 | CTSB | Rattus norvegicus | 4-Aminopyridine results in increased expression of CTSB mRNA | increases^expression | 24378259 |
| 14 | 504-24-5 | DPYSL4 | Rattus norvegicus | 4-Aminopyridine results in increased expression of DPYSL4 mRNA | increases^expression | 24378259 |
| 15 | 504-24-5 | GAD2 | Rattus norvegicus | 4-Aminopyridine results in increased expression of GAD2 mRNA | increases^expression | 25917026 |
| 16 | 504-24-5 | GAD2 | Rattus norvegicus | KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA] | increases^expression|increases^reaction | 25917026 |
| 17 | 504-24-5 | GALNT5 | Rattus norvegicus | 4-Aminopyridine results in decreased expression of GALNT5 mRNA | decreases^expression | 24378259 |
| 18 | 504-24-5 | GRIN2D | Mus musculus | [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein | affects^cotreatment|decreases^expression | 19911010 |
| 19 | 504-24-5 | HDAC5 | Rattus norvegicus | [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein | affects^cotreatment|affects^localization | 15773917 |
| 20 | 504-24-5 | JPH3 | Rattus norvegicus | 4-Aminopyridine results in increased expression of JPH3 mRNA | increases^expression | 24378259 |
| 21 | 504-24-5 | KCNA5 | 4-Aminopyridine results in decreased activity of KCNA5 protein | decreases^activity | 23261645 | |
| 22 | 504-24-5 | KCND3 | Rattus norvegicus | 4-Aminopyridine results in increased expression of KCND3 mRNA | increases^expression | 25917026 |
| 23 | 504-24-5 | KCND3 | Rattus norvegicus | KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA] | increases^expression|increases^reaction | 25917026 |
| 24 | 504-24-5 | KCNH2 | Homo sapiens | 4-Aminopyridine results in decreased activity of KCNH2 protein | decreases^activity | 19915712 |
| 25 | 504-24-5 | KCNIP1 | Rattus norvegicus | 4-Aminopyridine results in decreased expression of KCNIP1 mRNA | decreases^expression | 24378259 |
| 26 | 504-24-5 | KCNIP1 | Rattus norvegicus | 4-Aminopyridine results in increased expression of KCNIP1 mRNA | increases^expression | 25917026 |
| 27 | 504-24-5 | MAG | Rattus norvegicus | 4-Aminopyridine results in decreased expression of MAG mRNA | decreases^expression | 24378259 |
| 28 | 504-24-5 | MAP1LC3A | Rattus norvegicus | 4-Aminopyridine results in increased expression of MAP1LC3A mRNA | increases^expression | 24378259 |
| 29 | 504-24-5 | MAPK1 | Mus musculus | [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein | affects^cotreatment|increases^activity|increases^phosphorylation | 19911010 |
| 30 | 504-24-5 | MAPK1 | Mus musculus | Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein] | affects^cotreatment|decreases^reaction|increases^activity|increases^phosphorylation | 19911010 |
| 31 | 504-24-5 | MAPK3 | Mus musculus | [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein | affects^cotreatment|increases^activity|increases^phosphorylation | 19911010 |
| 32 | 504-24-5 | MAPK3 | Mus musculus | Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein] | affects^cotreatment|decreases^reaction|increases^activity|increases^phosphorylation | 19911010 |
| 33 | 504-24-5 | NCOR2 | Rattus norvegicus | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] | affects^cotreatment|affects^localization|decreases^reaction | 15773917 |
| 34 | 504-24-5 | NCOR2 | Rattus norvegicus | [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein | affects^cotreatment|affects^localization | 15773917 |
| 35 | 504-24-5 | NCOR2 | Rattus norvegicus | KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] | affects^cotreatment|affects^localization|decreases^reaction | 15773917 |
| 36 | 504-24-5 | NCOR2 | Rattus norvegicus | STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] | affects^cotreatment|affects^localization|decreases^reaction | 15773917 |
| 37 | 504-24-5 | OLR1583 | Rattus norvegicus | 4-Aminopyridine results in decreased expression of OLR1583 mRNA | decreases^expression | 24378259 |
| 38 | 504-24-5 | PLAT | [Bicuculline co-treated with 4-Aminopyridine co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein | affects^cotreatment|decreases^response to substance | 19911010 | |
| 39 | 504-24-5 | RARA | Rattus norvegicus | [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein] | affects^cotreatment|increases^activity|increases^reaction | 15773917 |
| 40 | 504-24-5 | RARA | Rattus norvegicus | Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] | affects^cotreatment|decreases^reaction|increases^activity|increases^reaction | 15773917 |
| 41 | 504-24-5 | RARA | Rattus norvegicus | KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] | affects^cotreatment|decreases^reaction|increases^activity|increases^reaction | 15773917 |
| 42 | 504-24-5 | RARA | Rattus norvegicus | STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] | affects^cotreatment|decreases^reaction|increases^activity|increases^reaction | 15773917 |
| 43 | 504-24-5 | S100A7A | Rattus norvegicus | 4-Aminopyridine results in decreased expression of S100A7A mRNA | decreases^expression | 24378259 |
| 44 | 504-24-5 | SYN1 | Mus musculus | SYN1 protein affects the susceptibility to 4-Aminopyridine | affects^response to substance | 22759588 |
| 45 | 504-24-5 | SYN1 | Mus musculus | SYN1 results in increased susceptibility to 4-Aminopyridine | increases^response to substance | 28132918 |
| 46 | 504-24-5 | SYN1 | Rattus norvegicus | 4-Aminopyridine results in increased expression of SYN1 protein modified form | increases^expression | 28132918 |
| 47 | 504-24-5 | SYN1 | Rattus norvegicus | ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form] | decreases^reaction|increases^expression | 28132918 |
| 48 | 504-24-5 | TRAF2 | Rattus norvegicus | 4-Aminopyridine results in increased expression of TRAF2 mRNA | increases^expression | 24378259 |
| Serial No. | Activity Name | Details | References (PubMed) | Other details EPA (U.S) | Clinical Trials (U.S. NIH) |
|---|---|---|---|---|---|
| 1 | 504-24-5 | 4-Pyridinamine |
Plant Variety and Essential oils
| Serial No. | Plant Name | Variety Name | Essential Oil | Compound Percentage |
|---|---|---|---|---|
| 1 | Mulethi | Mishri | Glucyrrhiza glabra mulethi essential oil |
Compound Image
2D Structure
Download Sdf File Download PDB File Download MOL File
View Similar Structures (External DB)