CSIR CIMAP AROMA | Compound Details

wortmannin Details

: IUPAC Name

:Chemical Class

:CAS Registry Number

19545-26-7

:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID	312145
Molecular Weight (g/mol)	428.432
Molecular Formula	C23H24O8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
IUPAC Name
Canonical SMILES	COCC3OC(=O)c4coc5C(=O)/C1=C(C(OC(C)=O)CC2(C)C(=O)CCC12)C3(C)c45
PUBCHEM IUPAC INCHIKEY	QDLHCMPXEPAAMD-QAIWCSMKSA-N
Solubility Level	2
Vapour Pressure	-7.985

Absorption and Metabolism information

XLOGP3 AA	1.2
CACTVS TPSA	109
BBB Level	3
Absorption Level	0
EXT PPB#Prediction	0
AlogP98	1.705
EXT CYP2D6#Prediction	0

Toxicological Information

Mouse Female FDA	Non-Carcinogen
Mouse Male FDA	Multi-Carcinogen
Rat Female FDA	Single-Carcinogen
Rat Male FDA	Single-Carcinogen
Ames Prediction	Non-Mutagen
Developmental / Reproductive Toxicity	Toxic
Rat Oral LD50	0.599599 g/kg_body_weight
Ocular Irritancy	Mild
Hepatotoxic#Prediction	0
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction	Degradable

Hazard(s) Identification

Physical hazards	not classified
Health hazards	Mild
Environmental hazards	not classified

About Table Headings

Compound Biological Activity

Serial No.	Cas No	Gene Symbol	Organism	Interaction	Interaction Actions	PubMed Id
1	19545-26-7	ABCB11	Homo sapiens	wortmannin results in decreased activity of ABCB11 protein	decreases^activity	20829430\|23956101
2	19545-26-7	ACOX1	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA]	decreases^expression\|decreases^reaction	23399309
3	19545-26-7	AGT	Rattus norvegicus	wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]	decreases^reaction\|increases^expression	15121739
4	19545-26-7	AHR	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]	decreases^reaction\|increases^expression	26466350
5	19545-26-7	AHR	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]	decreases^expression\|decreases^reaction	26466350
6	19545-26-7	AKT1	Didelphidae	wortmannin inhibits the reaction [Neomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15800129
7	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	19801633
8	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	11788791
9	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	16973122
10	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	16973122
11	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15608143
12	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	23001822
13	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation\|increases^reaction	20562903
14	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15177934
15	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation\|increases^reaction	20562903
16	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	12614848
17	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	16973122
18	19545-26-7	AKT1	Homo sapiens	wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	16973122
19	19545-26-7	AKT1	Homo sapiens	wortmannin results in decreased activity of AKT1 protein	decreases^activity	12556562
20	19545-26-7	AKT1	Mus musculus	wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity	18591783
21	19545-26-7	AKT1	Mus musculus	wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15178407
22	19545-26-7	AKT1	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	17464197
23	19545-26-7	AKT1	Mus musculus	wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein	decreases^activity\|decreases^phosphorylation	18948619
24	19545-26-7	AKT1	Mus musculus	wortmannin results in decreased expression of AKT1 protein	decreases^expression	15695173\|17129604
25	19545-26-7	AKT1	Rattus norvegicus	wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	16825486
26	19545-26-7	AKT1	Rattus norvegicus	wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	17728140
27	19545-26-7	ALB	Bos taurus	[wortmannin co-treated with U 0126] inhibits the reaction [[Estrogens co-treated with ALB protein] results in increased expression of S100G mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	20149859
28	19545-26-7	ALB	Bos taurus	[wortmannin co-treated with U 0126] inhibits the reaction [[Estrogens co-treated with ALB protein] results in increased expression of S100G protein]	affects^cotreatment\|decreases^reaction\|increases^expression	20149859
29	19545-26-7	ALPI	Homo sapiens	wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein]	increases^activity\|increases^reaction	16598758
30	19545-26-7	ALPI	Homo sapiens	wortmannin results in increased activity of ALPI protein	increases^activity	16598758
31	19545-26-7	ANXA5	Oryctolagus cuniculus	wortmannin inhibits the reaction [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Doxorubicin results in increased expression of ANXA5 protein]]	decreases^reaction\|increases^expression	18164246
32	19545-26-7	APOB	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA]	decreases^expression\|decreases^reaction	23399309
33	19545-26-7	APOB	Rattus norvegicus	wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides]	decreases^abundance\|decreases^expression\|decreases^reaction	23399309
34	19545-26-7	AREG	Rattus norvegicus	wortmannin results in decreased activity of AREG protein	decreases^activity	12589827
35	19545-26-7	ARNT	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]	decreases^reaction\|increases^expression	26466350
36	19545-26-7	ARNT	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]	decreases^expression\|decreases^reaction	26466350
37	19545-26-7	ATM	Mus musculus	ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]	affects^cotreatment\|affects^response to substance	20888899
38	19545-26-7	ATM		wortmannin results in decreased activity of ATM protein	decreases^activity	22119920
39	19545-26-7	ATR		wortmannin results in decreased activity of ATR protein	decreases^activity	22119920
40	19545-26-7	BAX	Homo sapiens	wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in increased expression of BAX protein]]	decreases^reaction\|increases^expression	15142122
41	19545-26-7	BAX	Homo sapiens	wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]	decreases^reaction\|increases^expression	15970427
42	19545-26-7	BCAR1	Homo sapiens	Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
43	19545-26-7	BCAR1	Homo sapiens	[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
44	19545-26-7	BCL2	Homo sapiens	wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein]	decreases^reaction\|increases^expression	21410490
45	19545-26-7	BCL2	Homo sapiens	wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with arsenic trioxide] results in decreased expression of BCL2 protein]	affects^cotreatment\|decreases^expression\|decreases^reaction	15142122
46	19545-26-7	BCL2	Rattus norvegicus	wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]	decreases^reaction\|increases^expression	19703415
47	19545-26-7	BCL2L1	Homo sapiens	wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]	decreases^expression\|decreases^reaction	15142122
48	19545-26-7	BDNF	Mus musculus	wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]	decreases^reaction\|increases^expression	17209049
49	19545-26-7	BDNF	Rodentia	wortmannin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]	decreases^reaction\|increases^expression	15647486
50	19545-26-7	BECN1	Rattus norvegicus	wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]	decreases^reaction\|increases^expression	23604964
51	19545-26-7	BECN1	Rattus norvegicus	wortmannin results in decreased expression of BECN1 protein	decreases^expression	23604964
52	19545-26-7	BIRC2	Homo sapiens	wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]	decreases^reaction\|increases^expression	19596284
53	19545-26-7	BIRC2	Homo sapiens	wortmannin results in decreased expression of BIRC2 mRNA	decreases^expression	15065019
54	19545-26-7	BIRC2	Homo sapiens	wortmannin results in decreased expression of BIRC2 protein	decreases^expression	15065019
55	19545-26-7	BIRC3	Homo sapiens	wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]	decreases^reaction\|increases^expression	19596284
56	19545-26-7	BIRC5	Homo sapiens	wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]	decreases^expression\|increases^reaction	18025287
57	19545-26-7	BIRC5	Homo sapiens	wortmannin results in decreased expression of BIRC5 mRNA	decreases^expression	15065019
58	19545-26-7	BIRC5	Homo sapiens	wortmannin results in decreased expression of BIRC5 protein	decreases^expression	15065019
59	19545-26-7	BIRC5	Mus musculus	wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein]	decreases^expression\|increases^reaction	22137261
60	19545-26-7	C5	Homo sapiens	wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]	decreases^expression\|decreases^reaction	16116186
61	19545-26-7	C5	Homo sapiens	wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]	affects^binding\|decreases^expression\|decreases^reaction	16116186
62	19545-26-7	C5	Homo sapiens	wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]	decreases^expression\|decreases^reaction	16116186
63	19545-26-7	C5	Homo sapiens	wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]	decreases^expression\|decreases^reaction	16116186
64	19545-26-7	CASP3	Homo sapiens	wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]]	decreases^reaction\|increases^activity	15142122
65	19545-26-7	CASP3	Homo sapiens	wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]	increases^activity\|increases^cleavage\|increases^reaction	17935137
66	19545-26-7	CASP3	Homo sapiens	wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]	increases^activity\|increases^cleavage\|increases^reaction	17935137
67	19545-26-7	CASP3	Homo sapiens	wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein]	increases^activity\|increases^reaction	25002221
68	19545-26-7	CASP3	Mus musculus	[Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein	affects^cotreatment\|increases^cleavage	26847702
69	19545-26-7	CASP3	Oryctolagus cuniculus	wortmannin inhibits the reaction [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]	decreases^reaction\|increases^activity	18164246
70	19545-26-7	CASP3	Rattus norvegicus	wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein]	decreases^activity\|decreases^reaction	24726520
71	19545-26-7	CASP3	Rattus norvegicus	wortmannin results in decreased activity of CASP3 protein	decreases^activity	21256120
72	19545-26-7	CASP7	Cricetulus griseus	wortmannin inhibits the reaction [Acrolein results in increased activity of CASP7 protein]	decreases^reaction\|increases^activity	17196791
73	19545-26-7	CASP7	Homo sapiens	wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein]	increases^activity\|increases^reaction	25002221
74	19545-26-7	CASP8	Rattus norvegicus	wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]	decreases^activity\|decreases^reaction	24726520
75	19545-26-7	CASP9	Cricetulus griseus	wortmannin inhibits the reaction [Acrolein results in increased activity of CASP9 protein]	decreases^reaction\|increases^activity	17196791
76	19545-26-7	CASP9	Rattus norvegicus	wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein]	decreases^activity\|decreases^reaction	24726520
77	19545-26-7	CAT	Mytilus galloprovincialis	wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of CAT mRNA]	decreases^reaction\|increases^expression	24316436
78	19545-26-7	CAT	Mytilus galloprovincialis	wortmannin inhibits the reaction [Estradiol results in increased expression of CAT mRNA]	decreases^reaction\|increases^expression	24316436
79	19545-26-7	CAV1	Homo sapiens	wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide]	decreases^reaction\|increases^response to substance	12640124
80	19545-26-7	CAV1	Homo sapiens	wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite]	decreases^reaction\|increases^response to substance	12640124
81	19545-26-7	CCL2	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	decreases^reaction\|increases^expression	22225513
82	19545-26-7	CCL5	Mus musculus	wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]	affects^binding\|decreases^reaction\|increases^abundance\|increases^activity	19016906
83	19545-26-7	CCL5	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]	decreases^reaction\|increases^expression	22225513
84	19545-26-7	CCL9	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL9 mRNA]	decreases^reaction\|increases^expression	22225513
85	19545-26-7	CCNA2	Mus musculus	wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]	decreases^reaction\|increases^expression	14971663
86	19545-26-7	CCNB1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
87	19545-26-7	CCNB1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
88	19545-26-7	CCND1	Homo sapiens	wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]	decreases^reaction\|increases^expression	28321046
89	19545-26-7	CCND1	Homo sapiens	wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein]	decreases^reaction\|increases^expression	19801633
90	19545-26-7	CCND1	Mus musculus	wortmannin results in decreased expression of CCND1 protein	decreases^expression	15695173
91	19545-26-7	CCND2	Homo sapiens	wortmannin results in increased expression of CCND2 mRNA	increases^expression	14745455
92	19545-26-7	CCND3	Mus musculus	[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein	affects^cotreatment\|affects^localization	17129604
93	19545-26-7	CCND3	Mus musculus	wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]	decreases^reaction\|increases^expression	10849422
94	19545-26-7	CCNE1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
95	19545-26-7	CCNE1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
96	19545-26-7	CCNE1	Mus musculus	wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]	decreases^reaction\|increases^expression	14971663
97	19545-26-7	CCR3	Homo sapiens	wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]	decreases^expression\|decreases^reaction	11544337
98	19545-26-7	CD36	Homo sapiens	wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]	decreases^reaction\|increases^expression	19640849
99	19545-26-7	CDC25A	Mus musculus	Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein]	decreases^expression\|increases^reaction	17129604
100	19545-26-7	CDC25A	Mus musculus	wortmannin results in decreased expression of CDC25A protein	decreases^expression	17129604
101	19545-26-7	CDC5L	Rattus norvegicus	wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]	affects^binding\|decreases^reaction\|increases^reaction	20629186
102	19545-26-7	CDH1	Homo sapiens	wortmannin results in increased expression of CDH1 protein	increases^expression	25856345
103	19545-26-7	CDK1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
104	19545-26-7	CDK1	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
105	19545-26-7	CDK2	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
106	19545-26-7	CDK2	Homo sapiens	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	26385184
107	19545-26-7	CDK2	Mus musculus	wortmannin results in decreased activity of CDK2 protein	decreases^activity	17129604
108	19545-26-7	CDK2	Mus musculus	wortmannin results in decreased expression of CDK2 protein	decreases^expression	17129604
109	19545-26-7	CDKN1A	Homo sapiens	wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]	decreases^reaction\|increases^expression	21617849
110	19545-26-7	CDKN1A	Homo sapiens	wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein]	decreases^reaction\|increases^expression	20878124
111	19545-26-7	CDKN1A	Homo sapiens	wortmannin results in decreased expression of CDKN1A protein	decreases^expression	22290291
112	19545-26-7	CDKN1A	Mus musculus	wortmannin results in increased expression of CDKN1A protein	increases^expression	15695173\|17129604
113	19545-26-7	CDKN1B	Homo sapiens	wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]	increases^expression\|increases^reaction	17935137
114	19545-26-7	CDKN1B	Homo sapiens	wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]	increases^expression\|increases^reaction	17935137
115	19545-26-7	CDKN1B	Mus musculus	Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]	increases^expression\|increases^reaction	17129604
116	19545-26-7	CDKN1B	Mus musculus	wortmannin results in increased expression of CDKN1B protein	increases^expression	17129604
117	19545-26-7	CFTR	Homo sapiens	wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]	decreases^reaction\|increases^activity	15563584
118	19545-26-7	CHEK1	Homo sapiens	wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	19261750
119	19545-26-7	CHEK1	Homo sapiens	wortmannin results in decreased expression of CHEK1 protein	decreases^expression	22409540
120	19545-26-7	CLU	Mus musculus	wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]	decreases^reaction\|increases^expression	19288494
121	19545-26-7	COL18A1	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]	decreases^expression\|decreases^reaction	13679210
122	19545-26-7	COL18A1	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]	decreases^expression\|decreases^reaction	13679210
123	19545-26-7	COL1A2	Homo sapiens	wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	decreases^reaction\|increases^expression	11343241
124	19545-26-7	CPT1A	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA]	decreases^expression\|decreases^reaction	23399309
125	19545-26-7	CREB1	Homo sapiens	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	23626723
126	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
127	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
128	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
129	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
130	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
131	19545-26-7	CRP	Homo sapiens	wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA]	decreases^reaction\|increases^expression	16263508
132	19545-26-7	CSF2	Homo sapiens	wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]	affects^cotreatment\|decreases^reaction\|increases^expression	23001822
133	19545-26-7	CSF2	Homo sapiens	wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	23001822
134	19545-26-7	CTNNB1	Homo sapiens	wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]	decreases^reaction\|increases^expression	28321046
135	19545-26-7	CTNNB1	Homo sapiens	wortmannin results in decreased expression of CTNNB1 protein	decreases^expression	11739494
136	19545-26-7	CXCL1	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein]	decreases^activity\|decreases^reaction	20117814
137	19545-26-7	CXCL2	Homo sapiens	wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15608143
138	19545-26-7	CXCL2	Homo sapiens	wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15608143
139	19545-26-7	CXCL2	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein]	decreases^activity\|decreases^reaction	20117814
140	19545-26-7	CXCL8	Homo sapiens	wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein]	decreases^reaction\|increases^activity	12975484
141	19545-26-7	CXCL8	Homo sapiens	wortmannin inhibits the reaction [CXCL8 results in decreased susceptibility to Cisplatin]	decreases^reaction\|decreases^response to substance	21742513
142	19545-26-7	CXCL8	Homo sapiens	wortmannin inhibits the reaction [CXCL8 results in decreased susceptibility to Paclitaxel]	decreases^reaction\|decreases^response to substance	21742513
143	19545-26-7	CXCL8	Homo sapiens	wortmannin inhibits the reaction [nickel subsulfide results in increased expression of CXCL8 mRNA]	decreases^reaction\|increases^expression	11978798
144	19545-26-7	CYP11A1	Rattus norvegicus	wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]	decreases^reaction\|increases^expression\|increases^reaction	25253736
145	19545-26-7	CYP11A1	Rattus norvegicus	wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	decreases^reaction\|increases^expression	25253736
146	19545-26-7	CYP1A1	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]	decreases^reaction\|increases^expression	26466350
147	19545-26-7	CYP1A1	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]	decreases^expression\|decreases^reaction	26466350
148	19545-26-7	CYP1A2	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]	decreases^reaction\|increases^expression	26466350
149	19545-26-7	CYP1A2	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]	decreases^expression\|decreases^reaction	26466350
150	19545-26-7	CYP1B1	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]	decreases^expression\|decreases^reaction	26466350
151	19545-26-7	CYP2E1	Rattus norvegicus	wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]	decreases^expression\|decreases^reaction	11306697
152	19545-26-7	CYP4Z1	Homo sapiens	wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	decreases^reaction\|increases^expression	22841774
153	19545-26-7	CYP4Z1	Homo sapiens	wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]	decreases^reaction\|increases^expression	22841774
154	19545-26-7	DDIT3	Homo sapiens	wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]	decreases^reaction\|increases^expression	17171638
155	19545-26-7	DDIT3	Homo sapiens	wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]	decreases^reaction\|increases^expression	17171638
156	19545-26-7	DKK1	Homo sapiens	wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]	decreases^reaction\|increases^expression	28321046
157	19545-26-7	DNMT3A	Homo sapiens	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]	affects^cotreatment\|decreases^expression\|decreases^reaction	23626723
158	19545-26-7	DNMT3B	Homo sapiens	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]	affects^cotreatment\|decreases^expression\|decreases^reaction	23626723
159	19545-26-7	DNMT3L	Homo sapiens	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein]	affects^cotreatment\|decreases^expression\|decreases^reaction	23626723
160	19545-26-7	E2F1	Mus musculus	wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein]	decreases^reaction\|increases^expression	14971663
161	19545-26-7	EDN1	Mus musculus	wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]	decreases^reaction\|increases^expression	12839867
162	19545-26-7	EGF	Chlorocebus aethiops	wortmannin inhibits the reaction [EGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein]]	affects^binding\|decreases^reaction\|increases^reaction	20629186
163	19545-26-7	EGF		naphtho(1,2-b)furan-4,5-dione inhibits the reaction [wortmannin inhibits the reaction [EGF protein results in increased activity of MMP9 protein]]	decreases^reaction\|increases^activity	23064031
164	19545-26-7	EGF		naphtho(1,2-b)furan-4,5-dione inhibits the reaction [wortmannin inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]	decreases^reaction\|increases^expression	23064031
165	19545-26-7	EGF		wortmannin inhibits the reaction [EGF protein results in increased activity of MMP9 protein]	decreases^reaction\|increases^activity	23064031
166	19545-26-7	EGF		wortmannin inhibits the reaction [EGF protein results in increased expression of MMP9 protein]	decreases^reaction\|increases^expression	23064031
167	19545-26-7	EGF		wortmannin results in decreased susceptibility to EGF protein	decreases^response to substance	23064031
168	19545-26-7	EGFR	Homo sapiens	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15177934
169	19545-26-7	EPOR	Homo sapiens	wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]	decreases^reaction\|increases^expression	20189893
170	19545-26-7	F3	Homo sapiens	wortmannin promotes the reaction [Histamine results in increased expression of F3]	increases^expression\|increases^reaction	16009787
171	19545-26-7	FASLG	Homo sapiens	wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein]	decreases^reaction\|increases^expression	20005289
172	19545-26-7	FGF1	Mus musculus	wortmannin results in decreased activity of FGF1 protein	decreases^activity	15695173
173	19545-26-7	FGF1	Rattus norvegicus	wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	decreases^reaction\|increases^expression	15121739
174	19545-26-7	FGF2		wortmannin inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein]	affects^binding\|decreases^reaction\|increases^activity\|increases^phosphorylation	11336793
175	19545-26-7	FGF7	Homo sapiens	wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]	decreases^reaction\|increases^expression	15803460
176	19545-26-7	FOS	Rattus norvegicus	wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]	decreases^reaction\|increases^expression	11687581
177	19545-26-7	FOXO3	Homo sapiens	wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]	decreases^activity\|decreases^reaction	23673518
178	19545-26-7	FOXP1	Homo sapiens	wortmannin results in decreased expression of FOXP1 protein	decreases^expression	25663935
179	19545-26-7	FSHB	Rattus norvegicus	wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]	decreases^reaction\|increases^expression\|increases^reaction	25253736
180	19545-26-7	FSHB	Rattus norvegicus	wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]	decreases^reaction\|increases^expression	25253736
181	19545-26-7	FTH1	Homo sapiens	wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]	decreases^reaction\|increases^expression	23829535
182	19545-26-7	G6PC	Homo sapiens	wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC mRNA]	decreases^expression\|decreases^reaction	24535192
183	19545-26-7	G6PC	Homo sapiens	wortmannin results in increased expression of G6PC mRNA	increases^expression	24535192
184	19545-26-7	GDF15	Homo sapiens	wortmannin results in increased expression of GDF15 protein	increases^expression	23178381
185	19545-26-7	GJA1	Rattus norvegicus	wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein]	decreases^expression\|decreases^reaction	26437446
186	19545-26-7	GLP1R	Rattus norvegicus	wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]	decreases^expression\|decreases^reaction\|increases^degradation	22925809
187	19545-26-7	GRN	Rattus norvegicus	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]	decreases^reaction\|decreases^response to substance\|increases^reaction	21820214
188	19545-26-7	GRN	Rattus norvegicus	U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]	decreases^reaction\|decreases^response to substance\|increases^reaction	21820214
189	19545-26-7	GRN	Rattus norvegicus	wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]	decreases^reaction\|decreases^response to substance	21820214
190	19545-26-7	GSK3B	Homo sapiens	wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	12614848
191	19545-26-7	GSK3B	Mus musculus	Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]	decreases^expression\|decreases^reaction	15842767
192	19545-26-7	GSK3B	Mus musculus	Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]	decreases^expression\|decreases^reaction	15842767
193	19545-26-7	GSK3B	Mus musculus	wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	decreases^expression\|decreases^reaction	23170834
194	19545-26-7	GSK3B	Mus musculus	wortmannin results in decreased expression of GSK3B protein modified form	decreases^expression	15842767
195	19545-26-7	GSTP1	Mytilus galloprovincialis	wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of GSTP1 mRNA]	decreases^reaction\|increases^expression	24316436
196	19545-26-7	H2AFX	Homo sapiens	wortmannin inhibits the reaction [decitabine results in increased expression of H2AFX protein]	decreases^reaction\|increases^expression	17991895
197	19545-26-7	H2AFX	Homo sapiens	wortmannin promotes the reaction [docetaxel results in increased expression of H2AFX protein]	increases^expression\|increases^reaction	20878124
198	19545-26-7	HIF1A	Homo sapiens	[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]	affects^cotreatment\|decreases^reaction\|increases^expression\|increases^reaction	16499871
199	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	15050414
200	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	13679210
201	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]	decreases^expression\|decreases^reaction	18927491
202	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]	affects^binding\|decreases^reaction\|increases^activity\|increases^expression	20335389
203	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]	decreases^reaction\|increases^expression	11424089\|19640849
204	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	20153296
205	19545-26-7	HIF1A	Homo sapiens	wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	23968725
206	19545-26-7	HIF1A	Homo sapiens	wortmannin results in decreased expression of HIF1A protein	decreases^expression	14726529
207	19545-26-7	HIF1A	Sus scrofa	wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	11514583
208	19545-26-7	HIF1A	Sus scrofa	wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein]	decreases^reaction\|increases^expression	11514583
209	19545-26-7	HMOX1	Bos taurus	wortmannin affects the expression of HMOX1 protein	affects^expression	19131585
210	19545-26-7	HMOX1	Homo sapiens	wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	23845594
211	19545-26-7	HMOX1	Homo sapiens	wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	23845594
212	19545-26-7	HMOX1	Homo sapiens	wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	18048804
213	19545-26-7	HMOX1	Homo sapiens	wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	20028456
214	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	24423726
215	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	17535857
216	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	17535857
217	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	17535857
218	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	17535857
219	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	17535857
220	19545-26-7	HMOX1	Mus musculus	wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	17535857
221	19545-26-7	HMOX1	Rattus norvegicus	wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	22022464
222	19545-26-7	HMOX1	Rattus norvegicus	wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	22709785
223	19545-26-7	HMOX1	Rattus norvegicus	wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]	decreases^reaction\|increases^expression	22056766
224	19545-26-7	HMOX1	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in increased expression of HMOX1 protein]	decreases^reaction\|increases^expression	20117814
225	19545-26-7	HSF1	Homo sapiens	wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]	decreases^reaction\|increases^expression	11424089
226	19545-26-7	HSPA1A	Homo sapiens	wortmannin results in decreased expression of HSPA1A protein	decreases^expression	20090934
227	19545-26-7	HSPA1A	Homo sapiens	wortmannin results in decreased expression of HSPA1A protein alternative form	decreases^expression	20090934
228	19545-26-7	HSPA5	Homo sapiens	wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	decreases^reaction\|increases^expression	19428936
229	19545-26-7	ICAM1	Homo sapiens	wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]	affects^binding\|decreases^reaction\|increases^reaction	23114885
230	19545-26-7	ICAM1	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein]	decreases^activity\|decreases^reaction	20117814
231	19545-26-7	IFNB1	Homo sapiens	wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]	affects^cotreatment\|decreases^reaction\|increases^expression	16399790
232	19545-26-7	IFNG	Homo sapiens	wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]	affects^cotreatment\|decreases^reaction\|increases^abundance	16968468
233	19545-26-7	IFNG	Homo sapiens	wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]	affects^cotreatment\|increases^expression\|increases^reaction	25352548
234	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]	decreases^reaction\|increases^activity	17520698
235	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]	decreases^reaction\|increases^activity	16499871
236	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]	decreases^reaction\|increases^activity	16499871
237	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]	decreases^reaction\|increases^activity	14745455
238	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]	decreases^reaction\|increases^expression	12569580
239	19545-26-7	IGF1	Homo sapiens	wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]	decreases^reaction\|increases^expression	20733350
240	19545-26-7	IGF1	Mus musculus	wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]	decreases^reaction\|increases^expression	19657059
241	19545-26-7	IGF1		wortmannin results in decreased susceptibility to IGF1 protein	decreases^response to substance	18398872
242	19545-26-7	IGF2	Homo sapiens	wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	decreases^reaction\|increases^expression	24055520
243	19545-26-7	IGF2	Homo sapiens	wortmannin results in decreased susceptibility to IGF2 protein	decreases^response to substance	24055520
244	19545-26-7	IL12A	Homo sapiens	wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]	affects^binding\|decreases^expression\|decreases^reaction	16116186
245	19545-26-7	IL17A	Mus musculus	wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]	decreases^reaction\|increases^expression	17982072
246	19545-26-7	IL1B	Homo sapiens	wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]	decreases^reaction\|increases^activity	16359550
247	19545-26-7	IL1B	Homo sapiens	wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]	decreases^reaction\|increases^expression	16359550
248	19545-26-7	IL1B	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]	decreases^reaction\|increases^expression\|increases^secretion	22952890
249	19545-26-7	IL1B	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]	decreases^reaction\|increases^expression	22952890
250	19545-26-7	IL1B		[wortmannin co-treated with IL1B protein] promotes the reaction [SIRT1 protein binds to SCX protein]	affects^binding\|affects^cotreatment\|increases^reaction	22936809
251	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]	decreases^expression\|decreases^reaction	22936809
252	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	decreases^reaction\|increases^expression	22936809
253	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]	decreases^reaction\|increases^expression	22936809
254	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]	decreases^reaction\|increases^expression	22936809
255	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]	decreases^reaction\|increases^expression	22936809
256	19545-26-7	IL1B		wortmannin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of RELA protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	22936809
257	19545-26-7	IL1B		wortmannin results in decreased susceptibility to IL1B protein	decreases^response to substance	22936809
258	19545-26-7	IL1RN	Mus musculus	wortmannin results in decreased expression of IL1RN mRNA	decreases^expression	26847702
259	19545-26-7	IL6	Mus musculus	wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]	decreases^reaction\|increases^expression	24631921
260	19545-26-7	IL6	Mus musculus	wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]	decreases^reaction\|increases^expression	24631921
261	19545-26-7	IL6	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein]	decreases^activity\|decreases^reaction	20117814
262	19545-26-7	INS	Homo sapiens	[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects^cotreatment\|affects^localization\|decreases^reaction	11574405
263	19545-26-7	INS	Homo sapiens	wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]	decreases^reaction\|decreases^response to substance	20015842
264	19545-26-7	INS		wortmannin inhibits the reaction [INS protein results in decreased expression of PCK1 mRNA]	decreases^expression\|decreases^reaction	10446394
265	19545-26-7	INS1	Mus musculus	wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]	decreases^reaction\|increases^expression	25805502
266	19545-26-7	IRAK3	Mus musculus	wortmannin results in decreased expression of IRAK3 mRNA	decreases^expression	26847702
267	19545-26-7	ITGAV	Homo sapiens	wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]	affects^activity\|affects^binding\|affects^localization\|decreases^reaction	15213856
268	19545-26-7	ITGB2	Homo sapiens	wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]	decreases^reaction\|increases^activity	16963453
269	19545-26-7	KLF4	Rattus norvegicus	wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	decreases^reaction\|increases^expression	21484412
270	19545-26-7	KNG1	Rattus norvegicus	KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
271	19545-26-7	LEP	Mus musculus	wortmannin results in decreased expression of LEP mRNA	decreases^expression	19254925
272	19545-26-7	LEP		wortmannin results in decreased susceptibility to LEP protein	decreases^response to substance	17993459
273	19545-26-7	MAP1LC3B	Mus musculus	wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein]	decreases^reaction\|increases^expression	26847702
274	19545-26-7	MAP1LC3B	Mus musculus	wortmannin results in decreased expression of MAP1LC3B protein	decreases^expression	26847702
275	19545-26-7	MAPK1	Homo sapiens	[bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	20522546
276	19545-26-7	MAPK1	Homo sapiens	wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	19477951
277	19545-26-7	MAPK1	Homo sapiens	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15177934
278	19545-26-7	MAPK3	Homo sapiens	[bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	20522546
279	19545-26-7	MAPK3	Homo sapiens	wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	19477951
280	19545-26-7	MAPK3	Homo sapiens	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	15177934
281	19545-26-7	MCL1	Homo sapiens	wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]	decreases^reaction\|increases^expression	15970427
282	19545-26-7	MCL1	Homo sapiens	wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein]	decreases^expression\|increases^reaction	17935137
283	19545-26-7	MCL1	Homo sapiens	wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein]	decreases^expression\|increases^reaction	17935137
284	19545-26-7	MCL1	Homo sapiens	wortmannin results in decreased expression of MCL1 protein	decreases^expression	23353698
285	19545-26-7	MIR200A	Homo sapiens	[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA	affects^cotreatment\|increases^expression	25969534
286	19545-26-7	MIR21	Homo sapiens	wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]	decreases^reaction\|increases^expression	25969534
287	19545-26-7	MIR21	Homo sapiens	wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]	decreases^reaction\|increases^expression	23052036
288	19545-26-7	MIR21	Homo sapiens	wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]	decreases^reaction\|increases^expression	23052036
289	19545-26-7	MIR22	Homo sapiens	[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA	affects^cotreatment\|increases^expression	25969534
290	19545-26-7	MMP2	Homo sapiens	brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]	decreases^activity\|decreases^expression\|increases^reaction	23707804
291	19545-26-7	MMP2	Homo sapiens	wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]	decreases^activity\|decreases^expression\|increases^reaction	23707804
292	19545-26-7	MMP2	Homo sapiens	wortmannin results in decreased expression of and results in decreased activity of MMP2 protein	decreases^activity\|decreases^expression	23707804
293	19545-26-7	MMP2	Homo sapiens	wortmannin results in decreased expression of MMP2	decreases^expression	23707804
294	19545-26-7	MMP9	Homo sapiens	wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]	decreases^expression\|decreases^reaction	24333868
295	19545-26-7	MMP9	Homo sapiens	wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]	decreases^reaction\|increases^activity\|increases^expression	23288142
296	19545-26-7	MMP9	Homo sapiens	wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]	decreases^activity\|increases^reaction	22033475
297	19545-26-7	MMP9	Homo sapiens	wortmannin results in decreased activity of MMP9 protein	decreases^activity	22033475
298	19545-26-7	MMP9	Rattus norvegicus	wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]	decreases^reaction\|increases^activity	20195827
299	19545-26-7	MPO	Rattus norvegicus	wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]	decreases^activity\|decreases^reaction	20117814
300	19545-26-7	MS4A2	Mus musculus	MS4A2 protein mutant form results in decreased susceptibility to wortmannin	decreases^response to substance	19467708
301	19545-26-7	MT1	Mus musculus	wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]	decreases^reaction\|increases^expression	11551972
302	19545-26-7	MT1	Mus musculus	wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]	decreases^reaction\|increases^expression	11551972
303	19545-26-7	MT3	Homo sapiens	wortmannin results in decreased susceptibility to MT3 protein	decreases^response to substance	19767621
304	19545-26-7	MTR	Homo sapiens	wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]	decreases^reaction\|increases^activity	14745455
305	19545-26-7	NEDD4	Rattus norvegicus	wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]	affects^binding\|decreases^reaction\|increases^reaction	20100827
306	19545-26-7	NFKB1	Mus musculus	wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]	affects^binding\|decreases^reaction\|increases^activity	18207479
307	19545-26-7	NFKBIA	Mus musculus	wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]	decreases^expression\|decreases^reaction	23170834
308	19545-26-7	NGF	Mus musculus	wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin]	decreases^reaction\|increases^response to substance	12815188
309	19545-26-7	NGF	Rattus norvegicus	wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]	affects^binding\|decreases^reaction\|increases^reaction	20629186
310	19545-26-7	NGF	Rattus norvegicus	wortmannin results in decreased activity of NGF protein	decreases^activity	21975456
311	19545-26-7	NOS2	Mus musculus	carvedilol promotes the reaction [wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]	decreases^reaction\|increases^expression\|increases^reaction	17159805
312	19545-26-7	NOS2	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]	decreases^reaction\|increases^expression	17159805
313	19545-26-7	NOS2	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]	decreases^reaction\|increases^expression	22952890
314	19545-26-7	NOS2	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]	decreases^reaction\|increases^expression	22952890
315	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	11788791
316	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]	affects^cotreatment\|decreases^reaction\|increases^expression\|increases^phosphorylation\|increases^reaction	20562903
317	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]	decreases^reaction\|increases^activity\|increases^reaction	15358673
318	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]	decreases^reaction\|increases^activity	15358673
319	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	18296501
320	19545-26-7	NOS3	Homo sapiens	wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]	affects^cotreatment\|decreases^reaction\|increases^expression\|increases^phosphorylation\|increases^reaction	20562903
321	19545-26-7	NOS3	Rattus norvegicus	wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]	affects^reaction\|increases^activity\|increases^phosphorylation	18317400
322	19545-26-7	NOTCH1	Mus musculus	wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]	decreases^activity\|decreases^reaction	17513037
323	19545-26-7	NQO1	Homo sapiens	wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]	decreases^reaction\|increases^expression	20028456
324	19545-26-7	NR5A1	Homo sapiens	wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]	decreases^reaction\|increases^activity	19549922
325	19545-26-7	OLR1		wortmannin affects the expression of OLR1 protein	affects^expression	19150883
326	19545-26-7	PCK1	Rattus norvegicus	[troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA	affects^cotreatment\|decreases^expression	10446394
327	19545-26-7	PDCD4	Homo sapiens	wortmannin results in increased expression of PDCD4 mRNA	increases^expression	17259349
328	19545-26-7	PDCD4	Homo sapiens	wortmannin results in increased expression of PDCD4 protein	increases^expression	17259349
329	19545-26-7	PDX1	Homo sapiens	wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	9873045
330	19545-26-7	PIK3CA	Homo sapiens	wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]	decreases^reaction\|increases^activity	16227402
331	19545-26-7	PIK3CA	Homo sapiens	wortmannin results in decreased activity of PIK3CA protein	decreases^activity	19036708
332	19545-26-7	PIK3CB	Homo sapiens	wortmannin results in decreased activity of PIK3CB protein	decreases^activity	11931710
333	19545-26-7	PIK3CD	Mus musculus	wortmannin results in decreased activity of PIK3CD protein	decreases^activity	21644799
334	19545-26-7	PIK3CG	Mus musculus	wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]	decreases^reaction\|increases^activity	15178407
335	19545-26-7	PIK3CG	Mus musculus	wortmannin results in decreased activity of PIK3CG protein	decreases^activity	21644799
336	19545-26-7	PIK3R1	Homo sapiens	wortmannin results in decreased activity of PIK3R1 protein	decreases^activity	19036708
337	19545-26-7	PIK3R1	Rattus norvegicus	wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]	decreases^expression\|decreases^reaction	27832966
338	19545-26-7	PPARA	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA]	decreases^expression\|decreases^reaction	23399309
339	19545-26-7	PPARD	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA]	decreases^expression\|decreases^reaction	23399309
340	19545-26-7	PPARG	Rattus norvegicus	wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA]	decreases^expression\|decreases^reaction	23399309
341	19545-26-7	PPM1D	Homo sapiens	wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein]	decreases^reaction\|increases^expression	22409540
342	19545-26-7	PRKCD	Homo sapiens	wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]	decreases^reaction\|increases^activity\|increases^localization	11424089
343	19545-26-7	PRKDC	Mus musculus	PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]	affects^cotreatment\|affects^response to substance	20888899
344	19545-26-7	PTEN	Homo sapiens	wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]	decreases^reaction\|increases^response to substance	17935137
345	19545-26-7	PTEN	Homo sapiens	wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]	decreases^reaction\|increases^response to substance	17935137
346	19545-26-7	PTEN	Rattus norvegicus	wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]	decreases^expression\|decreases^reaction	27832966
347	19545-26-7	PTEN	Rattus norvegicus	wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]	decreases^expression\|decreases^reaction	20100827
348	19545-26-7	PTGER1	Homo sapiens	wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]	affects^binding\|decreases^reaction\|increases^activity\|increases^phosphorylation	20335389
349	19545-26-7	PTGS2	Homo sapiens	wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]	decreases^reaction\|decreases^response to substance	18089846
350	19545-26-7	PTGS2	Homo sapiens	wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]	decreases^reaction\|increases^expression	23968725
351	19545-26-7	PTGS2	Homo sapiens	wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]	decreases^reaction\|increases^expression	15980035
352	19545-26-7	PTGS2	Homo sapiens	wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]	decreases^reaction\|increases^expression	15980035
353	19545-26-7	PTGS2	Mus musculus	wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]	decreases^reaction\|increases^expression	18840457
354	19545-26-7	PTGS2	Mus musculus	wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]	decreases^reaction\|increases^expression	18840457
355	19545-26-7	PTGS2	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]	decreases^reaction\|increases^expression	22952890
356	19545-26-7	PTGS2	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]	decreases^reaction\|increases^expression	22952890
357	19545-26-7	PTGS2		wortmannin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases^reaction\|increases^expression	15213311
358	19545-26-7	PTK2	Homo sapiens	Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
359	19545-26-7	PTK2	Homo sapiens	Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
360	19545-26-7	PTK2	Homo sapiens	Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation\|increases^reaction	10537051
361	19545-26-7	PTK2	Homo sapiens	oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
362	19545-26-7	PTK2	Homo sapiens	oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
363	19545-26-7	PTK2	Homo sapiens	oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]	affects^cotreatment\|increases^phosphorylation\|increases^reaction	10537051
364	19545-26-7	PTK2	Homo sapiens	[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein	affects^cotreatment\|increases^phosphorylation	10537051
365	19545-26-7	PTK2	Homo sapiens	[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein	affects^cotreatment\|increases^phosphorylation	10537051
366	19545-26-7	PTK2	Homo sapiens	[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein	affects^cotreatment\|increases^phosphorylation	10537051
367	19545-26-7	PTK2	Homo sapiens	[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein	affects^cotreatment\|increases^phosphorylation	10537051
368	19545-26-7	PTK2	Homo sapiens	[wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
369	19545-26-7	PXN	Homo sapiens	Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
370	19545-26-7	PXN	Homo sapiens	[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]	affects^cotreatment\|decreases^reaction\|increases^phosphorylation	10537051
371	19545-26-7	RAD23B	Homo sapiens	wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	decreases^reaction\|increases^expression	21742020
372	19545-26-7	RAD50	Homo sapiens	[wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein	affects^cotreatment\|decreases^expression	20878124
373	19545-26-7	RELA	Mus musculus	wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]	decreases^reaction\|increases^expression	17982072
374	19545-26-7	RIOX2	Homo sapiens	wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]	decreases^reaction\|increases^expression	24434654
375	19545-26-7	RPS6KB1	Mus musculus	wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]	affects^activity\|decreases^reaction	14516795
376	19545-26-7	RPS6KB1		wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	decreases^reaction\|increases^activity\|increases^phosphorylation	11861821
377	19545-26-7	RPS6KB2	Homo sapiens	wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]	decreases^reaction\|increases^activity	12087098
378	19545-26-7	SCG2	Homo sapiens	wortmannin results in decreased activity of SCG2 protein alternative form	decreases^activity	9473216
379	19545-26-7	SCT	Rattus norvegicus	wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]	decreases^reaction\|increases^response to substance	22194894
380	19545-26-7	SCT	Rattus norvegicus	wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]	decreases^reaction\|increases^response to substance	22194894
381	19545-26-7	SCT	Rattus norvegicus	wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]	decreases^reaction\|increases^activity	22194894
382	19545-26-7	SELENOP	Homo sapiens	wortmannin results in increased expression of SELENOP protein	increases^expression	24535192
383	19545-26-7	SERPINE1	Homo sapiens	wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]	decreases^reaction\|increases^expression\|increases^secretion	16458614
384	19545-26-7	SERPINE1	Homo sapiens	wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	decreases^reaction\|increases^expression	16458614
385	19545-26-7	SERPINH1	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]	decreases^expression\|decreases^reaction	13679210
386	19545-26-7	SERPINH1	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein]	decreases^expression\|decreases^reaction	13679210
387	19545-26-7	SESN2		wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein]	decreases^reaction\|increases^expression	25637945
388	19545-26-7	SFTPC	Mus musculus	wortmannin results in decreased expression of SFTPC protein	decreases^expression	15695173
389	19545-26-7	SHBG	Rattus norvegicus	wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]	decreases^reaction\|increases^expression	27832966
390	19545-26-7	SIRT1	Homo sapiens	wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein]	decreases^expression\|increases^reaction	18298901
391	19545-26-7	SIRT1	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]	decreases^expression\|decreases^reaction	22952890
392	19545-26-7	SLC1A1	Rattus norvegicus	wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]	decreases^reaction\|increases^activity	16150575
393	19545-26-7	SLC1A1	Rattus norvegicus	wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]	decreases^reaction\|increases^activity	22511482
394	19545-26-7	SLC1A1	Rattus norvegicus	wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]	decreases^reaction\|increases^activity	23602688
395	19545-26-7	SLC1A1	Rattus norvegicus	wortmannin results in decreased activity of SLC1A1 protein	decreases^activity	23262392\|23602688\|24355585
396	19545-26-7	SLC2A5	Rattus norvegicus	wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]	decreases^reaction\|increases^activity\|increases^expression	15691865
397	19545-26-7	SLC5A5	Homo sapiens	wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]	decreases^reaction\|increases^expression\|increases^reaction	20300827
398	19545-26-7	SOCS3	Mus musculus	wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]	decreases^reaction\|increases^expression	22685291
399	19545-26-7	SOCS3	Mus musculus	wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]	decreases^reaction\|increases^expression	22685291
400	19545-26-7	SOD	Mytilus galloprovincialis	wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of SOD mRNA]	decreases^reaction\|increases^expression	24316436
401	19545-26-7	SOD2	Rattus norvegicus	wortmannin results in increased expression of SOD2 mRNA	increases^expression	20596034
402	19545-26-7	SORT1	Mus musculus	wortmannin results in decreased expression of and results in increased degradation of SORT1 protein	decreases^expression\|increases^degradation	25805502
403	19545-26-7	SQSTM1	Mus musculus	[wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein	affects^cotreatment\|increases^expression	22459179
404	19545-26-7	SQSTM1	Mus musculus	wortmannin results in decreased expression of SQSTM1 protein	decreases^expression	22459179
405	19545-26-7	SQSTM1	Mus musculus	wortmannin results in increased expression of SQSTM1 protein	increases^expression	22459179
406	19545-26-7	STS	Homo sapiens	wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]	decreases^reaction\|increases^activity	16178010
407	19545-26-7	STS	Homo sapiens	wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]	decreases^reaction\|increases^activity	16178010
408	19545-26-7	STS	Homo sapiens	wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]	decreases^reaction\|increases^activity	16178010
409	19545-26-7	STS	Homo sapiens	wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]	decreases^reaction\|increases^activity	16178010
410	19545-26-7	TGIF1	Homo sapiens	wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]	decreases^reaction\|increases^expression	21649584
411	19545-26-7	TH	Mus musculus	wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]	affects^reaction\|decreases^expression	18950629
412	19545-26-7	TH	Rattus norvegicus	[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein	affects^cotreatment\|decreases^expression	23604964
413	19545-26-7	TH		wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]	decreases^reaction\|increases^expression	18950629
414	19545-26-7	THRA	Homo sapiens	wortmannin binds to and results in decreased activity of THRA protein	affects^binding\|decreases^activity	25752796
415	19545-26-7	TJP1	Homo sapiens	wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]	decreases^expression\|decreases^reaction	19252288
416	19545-26-7	TJP1	Homo sapiens	wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]	decreases^expression\|decreases^reaction	19252288
417	19545-26-7	TLR1	Gallus gallus	[FSL-1 lipoprotein, synthetic co-treated with wortmannin] results in increased expression of TLR1 mRNA	affects^cotreatment\|increases^expression	23405061
418	19545-26-7	TLR1	Gallus gallus	[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	affects^cotreatment\|increases^expression	23405061
419	19545-26-7	TLR21	Gallus gallus	wortmannin inhibits the reaction [CPG-oligonucleotide results in increased expression of TLR21 mRNA]	decreases^reaction\|increases^expression	23405061
420	19545-26-7	TLR2B	Gallus gallus	wortmannin inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR2B mRNA]	decreases^reaction\|increases^expression	23405061
421	19545-26-7	TLR3	Gallus gallus	[Poly I-C co-treated with wortmannin] results in decreased expression of TLR3 mRNA	affects^cotreatment\|decreases^expression	23405061
422	19545-26-7	TLR6	Gallus gallus	[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA	affects^cotreatment\|increases^expression	23405061
423	19545-26-7	TLR7	Gallus gallus	wortmannin inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]	decreases^reaction\|increases^expression	23405061
424	19545-26-7	TNF	Mus musculus	wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]	decreases^reaction\|increases^expression	17464197
425	19545-26-7	TNF	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]	decreases^reaction\|increases^expression\|increases^secretion	22952890
426	19545-26-7	TNF	Mus musculus	wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]	decreases^reaction\|increases^expression	22952890
427	19545-26-7	TP53	Homo sapiens	wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein]	decreases^reaction\|increases^expression	12676607
428	19545-26-7	TP53	Homo sapiens	wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein]	decreases^reaction\|increases^expression	22119920
429	19545-26-7	TP53	Homo sapiens	wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]	increases^expression\|increases^phosphorylation\|increases^reaction	18298901
430	19545-26-7	TP53	Homo sapiens	wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein	decreases^expression\|decreases^phosphorylation	22290291
431	19545-26-7	TP53	Rattus norvegicus	wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]	decreases^reaction\|increases^expression	11751435
432	19545-26-7	TP73	Homo sapiens	wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]	increases^expression\|increases^reaction	21214929
433	19545-26-7	TP73	Homo sapiens	wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein]	increases^expression\|increases^reaction	21214929
434	19545-26-7	VEGFA	Homo sapiens	wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]	decreases^reaction\|increases^expression	15050414
435	19545-26-7	VEGFA	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]	decreases^reaction\|increases^expression	13679210
436	19545-26-7	VEGFA	Homo sapiens	wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]	decreases^reaction\|increases^expression	13679210
437	19545-26-7	VEGFA	Homo sapiens	wortmannin inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein]	decreases^reaction\|increases^expression	18790786
438	19545-26-7	VEGFA	Homo sapiens	wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]	decreases^reaction\|increases^expression	23968725
439	19545-26-7	VIM	Homo sapiens	wortmannin results in decreased expression of VIM protein	decreases^expression	25856345
440	19545-26-7	XRCC5	Homo sapiens	[wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein	affects^cotreatment\|decreases^expression	20878124
441	19545-26-7	XRCC6	Homo sapiens	[wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein	affects^cotreatment\|decreases^expression	20878124
442	19545-26-7	YAP1	Homo sapiens	wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]	increases^expression\|increases^reaction	21214929
443	19545-26-7	YAP1	Homo sapiens	wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form]	increases^expression\|increases^reaction	21214929

Serial No.	Activity Name	Details	References (PubMed)	Other details EPA (U.S)	Clinical Trials (U.S. NIH)
1				19545-26-7	wortmannin

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