AromaDb: A Database of Plant's Aroma Molecules

Salicylic Acid Details

: IUPAC Name
2-hydroxybenzoic acid
:Chemical Class
Acid
:CAS Registry Number
69-72-7
:Description

:Fragrance Type
nutty aroma

Physical and Chemical properties

PUBCHEM ID 338
Molecular Weight (g/mol) 138.121
Molecular Formula C7H6O3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 1
IUPAC Name 2-hydroxybenzoic acid
Canonical SMILES O=C(O)c1ccccc1O
PUBCHEM IUPAC INCHIKEY YGSDEFSMJLZEOE-UHFFFAOYSA-N
Solubility Level 4
Vapour Pressure -4.23

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA 57.5
BBB Level 3
Absorption Level 0
EXT PPB#Prediction 0
AlogP98 1.217
EXT CYP2D6#Prediction 0

Toxicological Information

Mouse Female FDA Non-Carcinogen
Mouse Male FDA Single-Carcinogen
Rat Female FDA Non-Carcinogen
Rat Male FDA Non-Carcinogen
Ames Prediction Non-Mutagen
Developmental / Reproductive Toxicity Toxic
Rat Oral LD50 1.63853 g/kg_body_weight
Ocular Irritancy Moderate
Hepatotoxic#Prediction 1
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction Degradable

Hazard(s) Identification

Physical hazards not classified
Health hazards None
Environmental hazards not classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteractionInteraction Actions PubMed Id
169-72-7ADIPOQRattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA] decreases^expression|decreases^reaction 25108154
269-72-7AKR1C1Homo sapiensbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] decreases^reaction|decreases^response to substance|increases^reaction 23165153
369-72-7AKR1C1Homo sapiensSalicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] decreases^reaction|decreases^response to substance 23165153
469-72-7AKR1C1Homo sapiensSalicylic Acid results in decreased activity of AKR1C1 protein decreases^activity 19010312|23165153
569-72-7AKR1C2Homo sapiensSalicylic Acid results in decreased activity of AKR1C2 protein decreases^activity 19010312
669-72-7AKR1C2Homo sapiensSalicylic Acid results in increased expression of AKR1C2 mRNA increases^expression 20491607
769-72-7AKR1C3Homo sapiensSalicylic Acid results in decreased activity of AKR1C3 protein decreases^activity 19010312
869-72-7ARG1Rattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] decreases^expression|decreases^reaction 25108154
969-72-7ASIC3Rattus norvegicusSalicylic Acid results in decreased activity of ASIC3 protein decreases^activity 11588175
1069-72-7CCL2Rattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA] decreases^reaction|increases^expression 25108154
1169-72-7CXCL2Mus musculusSalicylic Acid results in increased expression of CXCL2 protein increases^expression 23178550
1269-72-7IL1AMus musculusSalicylic Acid results in increased expression of IL1A protein increases^expression 23178550
1369-72-7IL4Homo sapiensSalicylic Acid results in decreased expression of IL4 mRNA decreases^expression 11238116
1469-72-7IL6Mus musculusSalicylic Acid inhibits the reaction [Mercury results in increased expression of IL6] decreases^reaction|increases^expression 23742082
1569-72-7IL6Rattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA] decreases^reaction|increases^expression 25108154
1669-72-7MAFFHomo sapiensSalicylic Acid results in increased expression of MAFF mRNA increases^expression 20491607
1769-72-7MPOHomo sapiensSalicylic Acid results in increased activity of MPO protein increases^activity 24060682
1869-72-7MT1AHomo sapiensSalicylic Acid results in increased expression of MT1A mRNA increases^expression 20491607
1969-72-7NOS2Rattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] decreases^reaction|increases^expression 25108154
2069-72-7NR3C1Oncorhynchus mykissSalicylic Acid results in decreased expression of NR3C1 protein decreases^expression 16551645
2169-72-7PPARGRattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA] decreases^expression|decreases^reaction 25108154
2269-72-7PSMB10Homo sapiensSalicylic Acid results in increased expression of PSMB10 mRNA increases^expression 23165153
2369-72-7PSMB9Homo sapiensSalicylic Acid results in increased expression of PSMB9 mRNA increases^expression 23165153
2469-72-7PTGS2Salicylic Acid results in decreased expression of PTGS2 mRNA decreases^expression 16936242
2569-72-7SIRT1Rattus norvegicus[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid decreases^activity|decreases^response to substance 25108154
2669-72-7SLC22A11Homo sapiensSalicylic Acid results in decreased activity of SLC22A11 protein decreases^activity 12388633
2769-72-7SLC22A6Homo sapiensSalicylic Acid results in decreased activity of SLC22A6 protein decreases^activity 12388633
2869-72-7SLC22A7Homo sapiensSalicylic Acid results in decreased activity of SLC22A7 protein decreases^activity 12388633
2969-72-7SLC22A9Homo sapiensSalicylic Acid results in decreased activity of SLC22A9 protein decreases^activity 12388633
3069-72-7STAROncorhynchus mykissSalicylic Acid results in decreased expression of STAR mRNA decreases^expression 16551645
3169-72-7TNFRattus norvegicusSalicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA] decreases^reaction|increases^expression 25108154
3269-72-7TSPOOncorhynchus mykissSalicylic Acid results in decreased expression of TSPO mRNA decreases^expression 16551645
3369-72-7TXNHomo sapiensSalicylic Acid results in increased expression of TXN mRNA increases^expression 20491607
3469-72-7ABCG2Bos taurusABCG2 protein binds to and results in increased transport of Sodium Salicylate affects^binding|increases^transport 23652544
3569-72-7ANXA5Homo sapiensSodium Salicylate results in increased activity of ANXA5 protein increases^activity 10090950
3669-72-7CASP1Rattus norvegicusSodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein] decreases^activity|decreases^reaction 17561093
3769-72-7CASP1Rattus norvegicusSodium Salicylate results in increased activity of CASP1 protein increases^activity 17561093
3869-72-7CASP3Homo sapiensSodium Salicylate results in increased activity of CASP3 protein increases^activity 10090950
3969-72-7CASP3Rattus norvegicusSodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein] decreases^reaction|increases^activity 17561093
4069-72-7CASP8Rattus norvegicusSodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein] decreases^reaction|increases^activity 17561093
4169-72-7CASP8Rattus norvegicusSodium Salicylate results in increased activity of CASP8 protein increases^activity 17561093
4269-72-7CDKN1AHomo sapiensSodium Salicylate results in decreased activity of CDKN1A protein decreases^activity 15190207
4369-72-7CXCL8Homo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] decreases^reaction|increases^expression 10328874
4469-72-7EGFMus musculusSodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] affects^cotreatment|increases^activity|increases^phosphorylation|increases^reaction 10993886
4569-72-7FOXO3Mus musculusSodium Salicylate results in increased expression of FOXO3 protein increases^expression 21303813
4669-72-7HSF1Homo sapiensSodium Salicylate results in increased activity of HSF1 protein increases^activity 10328874
4769-72-7HSPA1BMus musculusSodium Salicylate affects the expression of HSPA1B protein affects^expression 16184763
4869-72-7HSPA7Homo sapiensSodium Salicylate results in decreased expression of HSPA7 mRNA decreases^expression 10328874
4969-72-7ICAM1Homo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] decreases^reaction|increases^expression 10328874
5069-72-7IFNGMus musculusSodium Salicylate results in decreased expression of IFNG protein decreases^expression 21303813
5169-72-7IKBKBMus musculusSodium Salicylate results in decreased expression of IKBKB protein modified form decreases^expression 21303813
5269-72-7IKBKBSodium Salicylate results in decreased activity of IKBKB protein decreases^activity 10480951
5369-72-7IL10Homo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] decreases^reaction|increases^expression 10328874
5469-72-7IL1BHomo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein] decreases^reaction|increases^expression|increases^secretion 10328874
5569-72-7IL1BHomo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] decreases^reaction|increases^expression 10328874
5669-72-7IL1BHomo sapiensSodium Salicylate results in decreased expression of IL1B mRNA decreases^expression 10328874
5769-72-7IL1BMus musculusSodium Salicylate results in decreased expression of IL1B protein decreases^expression 21303813
5869-72-7IL4Homo sapiensSodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein] affects^reaction|increases^activity 19767084
5969-72-7IL6Mus musculusSodium Salicylate results in decreased expression of IL6 protein decreases^expression 21303813
6069-72-7JUNRattus norvegicusSodium Salicylate inhibits the reaction [Paraquat results in increased expression of JUN protein] decreases^reaction|increases^expression 17561093
6169-72-7JUNRattus norvegicusSodium Salicylate results in decreased expression of JUN protein decreases^expression 17561093
6269-72-7MAPK1Mus musculusSodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases^activity|decreases^phosphorylation 10993886
6369-72-7MAPK1Rattus norvegicusSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 10357911
6469-72-7MAPK3Mus musculusSodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases^activity|decreases^phosphorylation 10993886
6569-72-7MAPK3Rattus norvegicusSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases^reaction|increases^activity|increases^phosphorylation 10357911
6669-72-7MCL1Homo sapiensSodium Salicylate results in increased expression of MCL1 protein increases^expression 10090950
6769-72-7MMP3Bos taurusSodium Salicylate inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA] decreases^reaction|increases^expression 10336562
6869-72-7NFKB1Mus musculusSodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]] affects^binding|affects^cotreatment|decreases^reaction|increases^reaction 9281604
6969-72-7NFKBIASodium Salicylate inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein] decreases^expression|decreases^reaction 10480951
7069-72-7NOS2Mus musculusSodium Salicylate results in decreased expression of NOS2 protein decreases^expression 10860828
7169-72-7NOS2Mus musculus[Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide decreases^chemical synthesis|decreases^expression 10860828
7269-72-7PEPDHomo sapiensSodium Salicylate results in decreased activity of PEPD protein decreases^activity 16991207
7369-72-7PPARGCaviaSodium Salicylate results in increased expression of PPARG mRNA increases^expression 18560754
7469-72-7PTGS1Ovis aries12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction 12538810
7569-72-7PTGS1Ovis aries12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction 12538810
7669-72-7PTGS1Ovis ariesHydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] affects^reaction|decreases^activity 12538810
7769-72-7PTGS1Ovis ariesManganese inhibits the reaction [12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]] decreases^activity|decreases^reaction 12538810
7869-72-7PTGS1Ovis aries[PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction|increases^abundance 12538810
7969-72-7PTGS1Ovis ariesSodium Salicylate results in decreased activity of PTGS1 protein decreases^activity 12538810
8069-72-7PTGS2Homo sapiensSodium Salicylate results in increased expression of PTGS2 mRNA increases^expression 14742690
8169-72-7PTGS2Homo sapiensSodium Salicylate results in increased expression of PTGS2 protein increases^expression 14742690
8269-72-7PTGS2Mus musculus12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] decreases^activity|decreases^reaction 12538810
8369-72-7PTGS2Mus musculusHydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] affects^reaction|decreases^activity 12538810
8469-72-7PTGS2Mus musculus[PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] decreases^activity|decreases^reaction|increases^abundance 12538810
8569-72-7PTGS2Mus musculusSodium Salicylate results in decreased activity of PTGS2 protein decreases^activity 12538810
8669-72-7RELAHomo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein] decreases^reaction|increases^expression 10328874
8769-72-7RPS6KB1Mus musculusSodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]] decreases^reaction|increases^activity|increases^phosphorylation|increases^reaction 10993886
8869-72-7RPS6KB1Mus musculusSodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] decreases^reaction|increases^activity|increases^phosphorylation 10993886
8969-72-7RPS6KB1Mus musculusSodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein decreases^activity|decreases^phosphorylation 10993886
9069-72-7SCARB1Homo sapiensSodium Salicylate results in decreased expression of SCARB1 protein decreases^expression 16816107
9169-72-7SCARB1Homo sapiensSodium Salicylate results in increased expression of SCARB1 protein increases^expression 16816107
9269-72-7SLC26A5Rattus norvegicusSodium Salicylate results in increased expression of SLC26A5 mRNA increases^expression 19173110
9369-72-7SLC26A5Rattus norvegicusSodium Salicylate results in increased expression of SLC26A5 protein increases^expression 19173110
9469-72-7SOD2Mus musculusSodium Salicylate results in increased expression of SOD2 protein increases^expression 21303813
9569-72-7TNFHomo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein] decreases^reaction|increases^expression|increases^secretion 10328874
9669-72-7TNFHomo sapiensSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases^reaction|increases^expression 10328874
9769-72-7TNFMus musculusSodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 17568627
9869-72-7TNFMus musculusSodium Salicylate results in decreased expression of TNF protein decreases^expression 21303813
9969-72-7TP53Rattus norvegicusSodium Salicylate inhibits the reaction [Paraquat results in increased expression of TP53 protein] decreases^reaction|increases^expression 17561093
Serial No. Activity Name DetailsReferences (PubMed)Other details EPA (U.S) Clinical Trials (U.S. NIH)
1 69-72-7 Salicylic Acid
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