Pyrenacantha staudtii is a medicinally important plant native to West Africa and belonging to the family Icacinaceae. It grows as a woody climber or liana and has long been used in traditional medicine to treat conditions such as diarrhea, pain, insomnia, hernia, and cases of threatened abortion. Scientific investigations have supported several of these ethnomedicinal uses, demonstrating anti-diarrheal, anti-ulcer, and antioxidant activities. Phytochemical studies have identified bioactive constituents including triterpenoid saponins and 3-carbomethoxypyridine, and toxicity assessments suggest that the plant is relatively safe at tested doses.