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Phenyl Ethyl Alcohol Details

: IUPAC Name
2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
:Chemical Class
Alcohol
:CAS Registry Number
35354-74-6
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID 72303
Molecular Weight (g/mol) 266.334
Molecular Formula C18H18O2
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 5
IUPAC Name 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Canonical SMILES C=CCc2ccc(O)c(c1ccc(O)c(CC=C)c1)c2
PUBCHEM IUPAC INCHIKEY FVYXIJYOAGAUQK-UHFFFAOYSA-N
Solubility Level 2
Vapour Pressure -7.321

Absorption and Metabolism information

XLOGP3 AA 5
CACTVS TPSA 40.5
BBB Level 1
Absorption Level 0
EXT PPB#Prediction 1
AlogP98 4.88
EXT CYP2D6#Prediction 1

Toxicological Information

Mouse Female FDA Non-Carcinogen
Mouse Male FDA Non-Carcinogen
Rat Female FDA Non-Carcinogen
Rat Male FDA Non-Carcinogen
Ames Prediction Non-Mutagen
Developmental / Reproductive Toxicity Toxic
Rat Oral LD50 0.788782 g/kg_body_weight
Ocular Irritancy Mild
Hepatotoxic#Prediction 1
Effected Human Genes

Ecological Information

Aerobic Biodegradability Prediction Non-Degradable

Hazard(s) Identification

Physical hazards not classified
Health hazards None
Environmental hazards not classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteractionInteraction Actions PubMed Id
135354-74-6ACACARattus norvegicushonokiol inhibits the reaction [Ethanol results in increased expression of ACACA mRNA] decreases^reaction|increases^expression 19371623
235354-74-6ACACARattus norvegicushonokiol results in decreased expression of ACACA mRNA decreases^expression 19371623
335354-74-6ACLYRattus norvegicushonokiol results in decreased expression of ACLY mRNA decreases^expression 19371623
435354-74-6ACTA2Rattus norvegicushonokiol affects the expression of ACTA2 protein affects^expression 21265825
535354-74-6ACTA2Rattus norvegicushonokiol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] decreases^reaction|increases^expression 21265825
635354-74-6ALOX15Homo sapiensALOX15 protein promotes the reaction [honokiol results in decreased expression of PPARG protein] decreases^expression|increases^reaction 20649594
735354-74-6ALOX15Homo sapiensALOX15 protein promotes the reaction [honokiol results in decreased expression of PTGS2 protein] decreases^expression|increases^reaction 20649594
835354-74-6ALOX15Homo sapienshonokiol results in increased expression of ALOX15 mRNA increases^expression 20649594
935354-74-6ALOX15Homo sapienshonokiol results in increased expression of ALOX15 protein increases^expression 20649594
1035354-74-6ALOX15Homo sapiens[honokiol results in increased expression of ALOX15 protein] which results in increased abundance of hydroxyoctadecadienoic acid increases^abundance|increases^expression 20649594
1135354-74-6BAXHomo sapienshonokiol results in increased expression of BAX protein increases^expression 15802533
1235354-74-6CASP3Homo sapienshonokiol results in increased activity of CASP3 protein increases^activity 15802533|25106108
1335354-74-6CASP8Homo sapienshonokiol results in increased activity of CASP8 protein increases^activity 15802533
1435354-74-6CASP9Homo sapienshonokiol results in increased activity of CASP9 protein increases^activity 15802533|25106108
1535354-74-6CCL2Rattus norvegicushonokiol affects the expression of CCL2 mRNA affects^expression 21265825
1635354-74-6CCL3Homo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] decreases^reaction|increases^expression 21147091
1735354-74-6COL1A1Rattus norvegicushonokiol affects the expression of COL1A1 mRNA affects^expression 21265825
1835354-74-6COL1A1Rattus norvegicushonokiol inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] decreases^reaction|increases^expression 21265825
1935354-74-6CTGFHomo sapienshonokiol inhibits the reaction [TGFB1 protein results in increased expression of CTGF mRNA] decreases^reaction|increases^expression 21265825
2035354-74-6CTGFRattus norvegicushonokiol affects the expression of CTGF mRNA affects^expression 21265825
2135354-74-6CTGFRattus norvegicushonokiol inhibits the reaction [TGFB1 protein results in increased expression of CTGF protein] decreases^reaction|increases^expression 21265825
2235354-74-6FASRattus norvegicushonokiol inhibits the reaction [Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]] affects^binding|decreases^reaction|increases^reaction 19371623
2335354-74-6FASRattus norvegicushonokiol inhibits the reaction [Ethanol results in increased expression of FAS mRNA] decreases^reaction|increases^expression 19371623
2435354-74-6FASRattus norvegicushonokiol results in decreased expression of FAS mRNA decreases^expression 19371623
2535354-74-6FN1Rattus norvegicushonokiol affects the expression of FN1 mRNA affects^expression 21265825
2635354-74-6FN1Rattus norvegicushonokiol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] decreases^reaction|increases^expression 21265825
2735354-74-6GABRA1[Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] affects^binding|affects^cotreatment|increases^activity 21699169
2835354-74-6GABRA1honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
2935354-74-6GABRA1honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] affects^binding|increases^activity 21699169
3035354-74-6GABRA1honokiol results in increased activity of [GABRA1 protein binds to GABRB3 protein] affects^binding|increases^activity 21699169
3135354-74-6GABRA2honokiol results in increased activity of [GABRA2 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
3235354-74-6GABRA3honokiol results in increased activity of [GABRA3 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
3335354-74-6GABRA5honokiol results in increased activity of [GABRA5 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
3435354-74-6GLO1Mus musculushonokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] decreases^activity|decreases^reaction 26723916
3535354-74-6ICAM1Rattus norvegicushonokiol affects the expression of ICAM1 mRNA affects^expression 21265825
3635354-74-6IL18Homo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] decreases^reaction|increases^expression 21147091
3735354-74-6IL1BHomo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] decreases^reaction|increases^expression 21147091
3835354-74-6IL4Homo sapienshonokiol results in decreased activity of IL4 protein decreases^activity 15802533
3935354-74-6IL6Mus musculushonokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein] affects^reaction|increases^expression 26723916
4035354-74-6LYNhonokiol results in decreased activity of LYN protein decreases^activity 25980585
4135354-74-6MCL1Homo sapienshonokiol results in decreased expression of MCL1 protein decreases^expression 15802533
4235354-74-6NFKB1Mus musculushonokiol analog inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein] decreases^reaction|increases^activity|increases^localization 19539808
4335354-74-6NFKB1Mus musculushonokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased activity of NFKB1 protein] decreases^reaction|increases^activity|increases^localization 19539808
4435354-74-6NOS2Homo sapienshonokiol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases^reaction|increases^chemical synthesis|increases^expression 21147091
4535354-74-6NOS2Mus musculushonokiol analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] decreases^reaction|increases^expression 19539808
4635354-74-6NOS2Mus musculushonokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] decreases^reaction|increases^expression 19539808
4735354-74-6PPARGHomo sapienshonokiol binds to and results in increased activity of PPARG protein affects^binding|increases^activity 23811337
4835354-74-6PPARGHomo sapienshonokiol results in decreased expression of PPARG mRNA decreases^expression 20649594
4935354-74-6PPARGHomo sapienshonokiol results in decreased expression of PPARG protein decreases^expression 20649594
5035354-74-6PPARGC1AMus musculus[Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein affects^cotreatment|increases^expression 26723916
5135354-74-6PTGS2Homo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 21147091
5235354-74-6PTGS2Homo sapienshonokiol results in decreased expression of PTGS2 mRNA decreases^expression 20649594
5335354-74-6PTGS2Homo sapienshonokiol results in decreased expression of PTGS2 protein decreases^expression 20649594
5435354-74-6PTGS2Mus musculushonokiol analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 19539808
5535354-74-6PTGS2Mus musculushonokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 19539808
5635354-74-6RELAMus musculushonokiol analog inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein] decreases^reaction|increases^activity|increases^localization 19539808
5735354-74-6RELAMus musculushonokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased activity of RELA protein] decreases^reaction|increases^activity|increases^localization 19539808
5835354-74-6SCD1Rattus norvegicushonokiol results in decreased expression of SCD1 mRNA decreases^expression 19371623
5935354-74-6SERPINE1Rattus norvegicushonokiol affects the expression of SERPINE1 mRNA affects^expression 21265825
6035354-74-6SERPINE1Rattus norvegicushonokiol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] decreases^reaction|increases^expression 21265825
6135354-74-6SREBF1Rattus norvegicushonokiol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] decreases^reaction|increases^expression 19371623
6235354-74-6SREBF1Rattus norvegicushonokiol results in decreased expression of SREBF1 mRNA decreases^expression 19371623
6335354-74-6TGFB1Homo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] decreases^reaction|increases^expression 21147091
6435354-74-6TGFB1Rattus norvegicushonokiol affects the expression of TGFB1 affects^expression 21265825
6535354-74-6TNFHomo sapienshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 21147091
6635354-74-6TNFMus musculushonokiol inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein] decreases^reaction|increases^expression 26723916
6735354-74-6TNFRattus norvegicushonokiol inhibits the reaction [Ethanol results in increased expression of TNF protein] decreases^reaction|increases^expression 19371623
Serial No. Activity Name DetailsReferences (PubMed)Other details EPA (U.S) Clinical Trials (U.S. NIH)
1 35354-74-6 Phenyl Ethyl Alcohol

Plant Variety and Essential oils

Serial No. Plant NameVariety NameEssential OilCompound Percentage
1 Rose, Damask Rose Noorjahan Rosa damascena Noorjahan essential oil
2 Rose, Damask Rose Ranisahiba Rose Ranisahiba essential oil
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