Dodecanoic Acid Details
:
IUPAC Name
dodecanoic acid
:Chemical Class
:CAS Registry Number
143-07-7
:Description
:Fragrance Type
Physical and Chemical properties
| PUBCHEM ID | 3893 |
| Molecular Weight (g/mol) | 200.318 |
| Molecular Formula | C12H24O2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 10 |
| IUPAC Name | dodecanoic acid |
| Canonical SMILES | CCCCCCCCCCCC(=O)O |
| PUBCHEM IUPAC INCHIKEY | POULHZVOKOAJMA-UHFFFAOYSA-N |
| Solubility Level | 3 |
| Vapour Pressure | -4.156 |
Absorption and Metabolism information
| XLOGP3 AA | |
| CACTVS TPSA | 37.3 |
| BBB Level | 1 |
| Absorption Level | 0 |
| EXT PPB#Prediction | 1 |
| AlogP98 | 4.568 |
| EXT CYP2D6#Prediction | 0 |
Toxicological Information
| Mouse Female FDA | Non-Carcinogen |
| Mouse Male FDA | Multi-Carcinogen |
| Rat Female FDA | Non-Carcinogen |
| Rat Male FDA | Non-Carcinogen |
| Ames Prediction | Non-Mutagen |
| Developmental / Reproductive Toxicity | Non-Toxic |
| Rat Oral LD50 | 4.87195 g/kg_body_weight |
| Ocular Irritancy | None |
| Hepatotoxic#Prediction | 0 |
| Effected Human Genes |
Ecological Information
| Aerobic Biodegradability Prediction | Degradable |
Hazard(s) Identification
| Physical hazards | not classified |
| Health hazards | Moderate |
| Environmental hazards | not classified |
Compound Biological Activity
| Serial No. | Cas No | Gene Symbol | Organism | Interaction | Interaction Actions | PubMed Id |
|---|---|---|---|---|---|---|
| 1 | 143-07-7 | CXCL8 | Homo sapiens | Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein] | decreases^reaction|increases^expression|increases^secretion | 18413660 |
| 2 | 143-07-7 | CXCL8 | Homo sapiens | lauric acid results in increased expression of and results in increased secretion of CXCL8 protein | increases^expression|increases^secretion | 18413660 |
| 3 | 143-07-7 | CXCL8 | Homo sapiens | parthenolide inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein] | decreases^reaction|increases^expression|increases^secretion | 18413660 |
| 4 | 143-07-7 | NOD2 | Homo sapiens | Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] | affects^binding|decreases^reaction|increases^reaction | 18413660 |
| 5 | 143-07-7 | NOD2 | Homo sapiens | lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein] | affects^binding|increases^reaction | 18413660 |
| 6 | 143-07-7 | PPARA | Homo sapiens | lauric acid binds to PPARA protein | affects^binding | 10403814 |
| 7 | 143-07-7 | PPARGC1A | Homo sapiens | lauric acid results in increased expression of PPARGC1A mRNA | increases^expression | 23056435 |
| 8 | 143-07-7 | RELA | Homo sapiens | Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein] | decreases^reaction|increases^activity | 18413660 |
| 9 | 143-07-7 | RELA | Homo sapiens | lauric acid results in increased activity of RELA protein | increases^activity | 18413660 |
| 10 | 143-07-7 | RELA | Homo sapiens | parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein] | decreases^reaction|increases^activity | 18413660 |
| 11 | 143-07-7 | TTR | lauric acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein] | affects^binding|decreases^reaction | 22859314 | |
| 12 | 143-07-7 | CXCL8 | Homo sapiens | Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein] | decreases^reaction|increases^expression|increases^secretion | 18413660 |
| 13 | 143-07-7 | CXCL8 | Homo sapiens | lauric acid results in increased expression of and results in increased secretion of CXCL8 protein | increases^expression|increases^secretion | 18413660 |
| 14 | 143-07-7 | CXCL8 | Homo sapiens | parthenolide inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein] | decreases^reaction|increases^expression|increases^secretion | 18413660 |
| 15 | 143-07-7 | NOD2 | Homo sapiens | Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] | affects^binding|decreases^reaction|increases^reaction | 18413660 |
| 16 | 143-07-7 | NOD2 | Homo sapiens | lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein] | affects^binding|increases^reaction | 18413660 |
| 17 | 143-07-7 | PPARA | Homo sapiens | lauric acid binds to PPARA protein | affects^binding | 10403814 |
| 18 | 143-07-7 | PPARGC1A | Homo sapiens | lauric acid results in increased expression of PPARGC1A mRNA | increases^expression | 23056435 |
| 19 | 143-07-7 | RELA | Homo sapiens | Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein] | decreases^reaction|increases^activity | 18413660 |
| 20 | 143-07-7 | RELA | Homo sapiens | lauric acid results in increased activity of RELA protein | increases^activity | 18413660 |
| 21 | 143-07-7 | RELA | Homo sapiens | parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein] | decreases^reaction|increases^activity | 18413660 |
| 22 | 143-07-7 | TTR | lauric acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein] | affects^binding|decreases^reaction | 22859314 |
| Serial No. | Activity Name | Details | References (PubMed) | Other details EPA (U.S) | Clinical Trials (U.S. NIH) |
|---|---|---|---|---|---|
| 1 | 143-07-7 | Dodecanoic Acid |
Plant Variety and Essential oils
| Serial No. | Plant Name | Variety Name | Essential Oil | Compound Percentage |
|---|---|---|---|---|
| 1 | Periwinkle, Sadabahar, Sadafuli | Dhawal | Catharanthus roseus dhawal essential oil | |
| 2 | Blackcurrant | Ribes nigrum essential oil | ||
| 3 | Goatweed | Ageratum conyzoides essential oil | ||
| 4 | Plymouth thistle | Carduus pycnocephalus essential oil | ||
| 5 | Papaya | Carica papaya essential oil | ||
| 6 | Papaya | Carica papaya essential oil | ||
| 7 | Fireweed | Crinum latifolium essential oil |
Compound Image
2D Structure
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